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62篇 您的检索式:作者名="PANTEL R"
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1Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy显示文摘AIM: To study the prognostic value of adjuvant chemo-therapy in patients with pancreatic, ductal adenocar-cinoma.METHODS: Lymph nodes from 106 patients with resectable pancreatic ductal adenocarcinoma were systematically sampled. A total of 318 lymph nodes classified histopathologically as tumor-free were examined using sensitive immunohistochemical assays. Forty-three (41%) of the 106 patients were staged as pT1/2, 63 (59%) as pT3/4, 51 (48%) as pN0, and 55 (52%) as pN1. The study population included 59 (56%) patients exhibiting G1/2, and 47 (44%) patients with G3 tumors. Patients received no adjuvant chemo- or radiation therapy and were followed up for a median of 12 (range: 3.5 to 139) mo.RESULTS: Immunostaining with Ber-EP4 revealed nodal microinvolvement in lymph nodes classified as “tumor free” by conventional histopathology in 73 (69%) out of the 106 patients. Twenty-nine (57%)of 51 patients staged histopathologically as pN0 had nodal microinvolvement. The five-year survival probability for pN0-patients was 54% for those without nodal microinvolvement and 0% for those with nodal microinvolvement. Cox-regression modeling revealed the independent prognostic effect of nodal microinvolvement on recurrence-free (relative risk 2.92, P = 0.005) and overall (relative risk 2.49, P = 0.009) survival.CONCLUSION: The study reveals strong and independent prognostic significance of nodal microinvolvement in patients with pancreatic ductal adenocarcinoma who have received no adjuvant therapy. The addition of immunohistochemical findings to histopathology reports may help to improve risk stratification of patients with pancreatic cancer.Emre F Yekebas Dean Bogoevski Michael Bubenheim Bjrn-Christian Link Jussuf T Kaifi Robin Wachowiak Oliver Mann Asad Kutup Guellue Cataldegirmen Lars Wolfram Andreas Erbersdobler Christoph Klein Klaus Pantel Jakob R Izbicki 2006World Journal of Gastroenterology2006,12,40:3
2Deferred prose- cutions and the independent monitor 显示文摘Robinson J K Urofsky P E Pantel C R 2005International Journal of Disclosure and Governance2005,,4:1
3Detection and clinical importance of micrometastatic disease显示文摘Pantel K Cote R J Fodstad O 1999Natl Cancer Inst1999,91,13:1
4Backward wave oscillation in an unloaded waveguide显示文摘R H Pantell 1959Proc IRE1959,,47:1
5Thermal effects in doped fibers显示文摘Davis M K Digonnet M J F Pantell R H 1998Lightwave Technol1998,16,6:1
6Detection and clinical importance of micrometastatic disease显示文摘PANTEL K COTE R J FODSTAD O 1999J Nat Cancer lnst1999,91,13:1
7Effectiveness of radical systematic mediastinal lymphadenectomy in patients with resectable non-small cell lung cancer:results of a prospective randomized trial显示文摘Izbicki J R Passlick B Pantel K 1998Ann Surg1998,227,:1
8Thermal effects in doped fibers显示文摘DAVIS M K DIGONNET M J F PANTELL R H 1998IEEE Journal of Lightwave Technology1998,16,6:1
9Cancer micrometastasis and tumour dormancy显示文摘Wikman H Vessella R Pantel K 2008APMIS2008,116,78:1
10Ferroelectric harmonic generator and the large-signal microwave characteristics of a ferroelectric ceramic显示文摘DOMENICO M D JOHNSON D A PANTELL R H 1962J Appl Phys1962,33,:1
11Thermal effects in doped fibers显示文摘Davis M K Digonnet M J F Pantell R H 1998IEEEJ Lightwave Technol1998,16,6:1
12Detection, clinical relevance and specific biological properties of disseminating tumour ceils显示文摘Pantel K Brakenhoff R H Brandt B 2008Nat Rev Cancer2008,8,5:1
13In vivo depletion of B cells using a combination of high-dose cytosine arabinoside/mitoxantrone and rituximab for autografting in patients with non-Hodgkin's lymphoma 显示文摘Voso MT Pantel G Weis M Schmidt P Martin S Moos M Ho AD Haas R Hohaus S 2000Br J Haematol2000,109,4:1
14Deteclion, clinical relevance and specific biological properties of disseminating tumour cells显示文摘Pantel K Brakenhoff R H Brandt B 2008Nature Reviews Cancer2008,8,5:1
15Cancer micrometastasis and tumour dormancy显示文摘Wikman H Vessella R Pantel K 2008APMIS2008,116,78:1
16Detection and clinical importance of micrometastatic disease显示文摘Pantel K Cote R J Fodstad O 1999J Nat Cancer Inst1999,91,13:1
17Dissecting the metastatic cascade显示文摘Pantel K Brakenhoff R H 2004Nat Rev Cancer2004,4,6:1
18Optical patterns thermally self-defocused light显示文摘CALLEN W R HUTH B G PANTELL R H 1967Appl Phy Lett1967,11,3:1
19Development and Validation of Improved RP-HPLC method for Identification and Estimation of Ellagic and Gallic acid in Triphala churna显示文摘PATEL MADHAVI G PATEL VISHAL R PANTEL RAKESH K 2010International Journal of Chem Tech Research2010,2,3:1
20Cancer micrometastasis and tumour dormancy显示文摘Wikman H Vessella R Pantel K 2008APMIS2008,116,78:1
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