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| 1 | Ten years of sorafenib in hepatocellular carcinoma: Are there any predictive and/or prognostic markers?显示文摘Sorafenib has been considered the standard of care for patients with advanced unresectable hepatocellular carcinoma(HCC) since 2007 and numerous studieshave investigated the role of markers involved in the angiogenesis process at both the expression and genetic level and clinical aspect. What results have ten years of research produced? Several clinical and biological markers are associated with prognosis. The most interesting clinical parameters are adverse events, Barcelona Clinic Liver Cancer stage, and macroscopic vascular invasion, while several single nucleotide polymorphisms and plasma angiopoietin-2 levels represent the most promising biological biomarkers. A recent pooled analysis of two phase III randomized trials showed that the neutrophil-to-lymphocyte ratio, etiology and extra-hepatic spread are predictive factors of response to sorafenib, but did not identify any predictive biological markers. After 10 years of research into sorafenib there are still no validated prognostic or predictive factors of response to the drug in HCC. The aim of the present review was to summarize 10 years of research into sorafenib, looking in particular at the potential of associated clinical and biological markers to predict its efficacy in patients with advanced HCC. | Giorgia Marisi Alessandro Cucchetti Paola Ulivi Matteo Canale Giuseppe Cabibbo Leonardo Solaini Francesco G Foschi Serena De Matteis Giorgio Ercolani Martina Valgiusti Giovanni L Frassineti Mario Scartozzi Andrea Casadei Gardini | 2018 | World Journal of Gastroenterology2018，24，36： | 14 |
| 2 | Axillary dissection versus no axillary dissection in patients with sentinel-node micrometastases (IBCSG 23–01): a phase 3 randomised controlled trial显示文摘 | Viviana Galimberti Bernard F Cole Stefano Zurrida Giuseppe Viale Alberto Luini Paolo Veronesi Paola Baratella Camelia Chifu Manuela Sargenti Mattia Intra Oreste Gentilini Mauro G Mastropasqua Giovanni Mazzarol Samuele Massarut Jean-Rémi Garbay Janez Zgajn | 2013 | Lancet Oncology2013，，4： | 2 |
| 3 | Pedal-plantar loop technique for a challenging below-the-knee chronic total occlusion : a novel approach to percutaneous revascularization in critical lower limb ischemia显示文摘 | Fusaro M Dalla Paola L Biondi-Zoccai G | 2007 | J Invasive Cardiol2007，19，2： | 1 |
| 4 | Preparation ofpolycstlaline photocatalystsimp regnated with vairosu transition Metlaions:characteirzation and photo actalytic activity for the degradation of 4-nitrophenol显示文摘 | Paola A Marie G Pahnisano | | 0，，： | 1 |
| 5 | Pedal -plantar loop tech- nique for a challenging below - the - knee chronic total occlusion : a no- vel approach to percutaneous revascularization in critical lower limb is- chemia 显示文摘 | Fusaro M Dalla Paola L Biondi -Zoccai G | 2007 | J Invasive Cardio12007，19，2： | 1 |
| 6 | Photocatalytic ac- tivity of nanocrystalline TiO2 (brookite, rutile and brookite- based) powders prepared by thermohydrolysis of TIC14 in a- queous chloride solutions 显示文摘 | Di Paola A Cufalo G Addamo M | 2008 | Colloids and Surfaces A: Physicochem Eng Aspects2008，317，13： | 1 |
| 7 | Photodegradation of lincomycin in aqueous solution显示文摘 | Di Paola A Addamo M Augugliaro V García-López E Loddo V Marcì G Palmisano L | | 0，，： | 1 |
| 8 | Peripheral angioplasty as the first-choice revascularization procedure in diabetic patients with critical limb ischemia:prospective study of 993 consecutive patients hospitalized and followed between 1999 and 2003显示文摘 | Faglia E Dalla Paola L Clerici G | 2005 | Eur J Vasc Endovasc Surg2005，29，6： | 1 |
| 9 | Histopathological features of diagnostic and clinical relevance in autoimmune pancreatitis: a study on 53 resection specimens and 9 biopsy specimens显示文摘 | Giuseppe Zamboni Jutta Lüttges Paola Capelli Luca Frulloni Giorgio Cavallini Paolo Pederzoli Alexander Leins Daniel Longnecker Günter Kl?ppel | 2004 | Virchows Archiv2004，，6： | 1 |
| 10 | Influence of red mud,zeolite and lime on heavy metal immobilization, culturableheterotrophic microbial populations and enzyme activitiesin a contaminated soil显示文摘 | Giovanni G Paola C Laura S | 2007 | Geoderma2007，142，： | 1 |
| 11 | Effects of verbascoside, biotechnologically purified by Syringa vulgaris plant cell cultures, in a rodent model of periodontitis 显示文摘 | PAOLA R DI OTERI G MAZZON E | 2011 | J Pharm Pharmacol2011，63，5： | 1 |
| 12 | Relationship between types of human papillomavirus and Langerhans'cells in cervical condyloma and intraepithelial neoplasia显示文摘 | Morelli AE Sananes C Di Paola G | 1993 | Am J Clin Pathol1993，99，2： | 1 |
| 13 | Influence of red mud, zeolite and lime on heavy metal immobilization, culturable heterotrophic microbial populations and enzyme activities in a contaminated soil显示文摘 | GIOVANNI G PAOLA C LAURA S | 2007 | Geoderma2007，142，12： | 1 |
| 14 | Crystal structure of the human urokinase plasminogen activator receptor bound to an antagonist peptide 显示文摘 | Paola L Marie HLD Henrik G | 2005 | The EMBO Journal2005，24，： | 1 |
| 15 | Postprandial anti-inflammatory and antioxidant effects of extra virgin olive oil 显示文摘 | Paola B Claudio G Marco V | 2007 | Atherosclerosis2007，190，： | 1 |
| 16 | The effects of recombinant TSH on bone turnover markers and serum osteoprotegerin and RANKL levels显示文摘 | Martini G Gennari L De Paola V | 2008 | Thyroid2008，18，4： | 1 |
| 17 | Sensory properties and aroma compounds of sweet Fiano wine 显示文摘 | Alessandro G Angelita G Paola P | 2007 | Food Chemistry2007，103，4： | 1 |
| 18 | Phototransformations of solid pentachlorophenol显示文摘 | Paola P Pierre P Chantal G | 1998 | Journal of Photochemistry and Photobiology A:Chemistry1998，119，： | 1 |
| 19 | Peripheral angio-plasty as the first-choice revascularization procedure in di-abetic patients with critical limb ischemia:prospective study of 993 consecutive patients hospitalized and followed be-tween 1999 and 2003显示文摘 | Faglia E Dalla Paola L Cleriei G et a1 | | 0，，06： | 1 |
| 20 | Peripheral angioplasty as the first choice revascularization procedure in diabetic patients with critical limb ischemia:prospective study of 993 consecutive patients hosp italized and followed between 1999 and 2003显示文摘 | Faglia E Dalla Paola L Clerici G | 2005 | Eur J Vasc Endovasc Surg2005，29，6： | 1 |
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