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| 1 | Tourette syndrome associated with attention deficit hyperactivity disorder: The impact of tics and psychopharmacological treatment options显示文摘Tourette syndrome(TS) is a neurodevelopmental disorder characterized by multiple chronic motor and vocal tics beginning in childhood. Several studies describe the association between TS and attention deficit hyperactivity disorder(ADHD). Fifty percent of children diagnosed with ADHD have comorbid tic disorder. ADHD related symptoms have been reported in 35% to 90% of children with TS. Since ADHD is the most prevalent comorbid condition with TS and those with concomitant TS and ADHD present with considerable psychosocial and behavioral impairments, it is essential for clinicians to be familiar with these diagnoses and their management. This paper highlights the association between treating ADHD with stimulants and the development of tic disorders. The two cases discussed underscore the fact that children with TS may present with ADHD symptomatology prior to the appearance of any TS related symptoms. Appropriate management of TS in a patient diagnosed with ADHD can lead to quality of life improvements and a reduction in psychosocial impairments. | Olumide O Oluwabusi Susan Parke Paul J Ambrosini | 2016 | World Journal of Clinical Pediatrics2016，5，1： | 27 |
| 2 | Highly efficient derivation of ventricular cardiomyocytes from induced pluripotent stem cells with a distinct epigenetic signature显示文摘从 pluripotent 干细胞导出的 Cardiomyocytes 能在药测试,疾病建模和基于房间的治疗被使用。没有 procardiogenic 生长因素,然而,从 pluripotent 干细胞的 cardiomyogenesis 的效率通常是低的,产生 cardiomyocyte 人口是异构的。这里,我们证明导致的 pluripotent 干细胞( iPSCs )能从鼠科的室的 myocytes ( VM )被导出,并且与从各种各样的体的房间类型导出的 iPSCs 的另外的报告一致,自发地作为与遗传上匹配的胚胎的干细胞(转换字符)或 iPSCs 相比区分 cardiomyocytes 进跳动的显著地更高的倾向从尾巴尖端成纤维细胞导出的 导出VM 的 iPSCs ( ViPSCs )展览。惊人地,导出 ViPSC 的 cardiomyocytes 显示的多数室的显型。在 ViPSCs 的提高的室的 myogenesis 在区别的早阶段经由心血管的祖先的增加的数字被调停。以便从 ViPSCs 调查提高的室的 myogenesis 的机制,我们执行了全球基因表示和 DNA methylation 分析,它揭示了可以涉及在 pluripotent 干细胞指定 VM 命运的不同 epigenetic 签名。 | Huansheng Xu B Alexander Yi Hao Wu Christoph Bock Hongcang Gu Kathy O Lui Joo-Hye C Park Ying Shao Alyssa K Riley Ibrahim J Domian Erding Hu Robert Willette John Lepore Alexander Meissner Zhong Wang Kenneth R Chien | 2012 | Cell Research2012，22，1： | 7 |
| 3 | Selenocysteine tRNAs as Central Components of Selenoprotein Biosynthesis in Eukaryotes显示文摘Selenocysteine (Sec) tRNAs serve as carrier molecules for the biosynthesis of Sec from serine and to donate Sec to protein in response to specific UGA codons. In this study, we describe the current status of Sec tRNAs in higher animals and further we exarnine: (i) the Sec tRNA population in Drosophila; (ii) transcription of the Sec tRNA in vivo (in Xenopus oocytes) and in vitro (in Xenopus oocyte extracts); (iii) the effect of selenium on the Sec tRNA population in various rat tissues following replenishment of extremely selenium deficient rats with this element; and (iv) the biosynthesis of the modified bases on Sec tRNA in Xenopus | SANG ICK PARK JIN Mo PARK HAROLD S. CHITTUM EUN SUNG YANG BRADLEY A. CARLSON BYEONG JAE LEE AND DOLPH L. HATFIELD(Laboratory of Experimental Chrcinogenesis, National Cancer Insti tute, National Institutes of Health, Bethesda, MD 20892USA Laboratory o | 1997 | Biomedical and Environmental Sciences1997，10，2： | 2 |
| 4 | Green tea extract attenuates hepatic steatosis by decreasing adipose lipogenesis and enhancing hepatic antioxidant defenses in ob/ob mice显示文摘 | Hea Jin Park Dana A. DiNatale Min-Yu Chung Young-Ki Park Ji-Young Lee Sung I. Koo Meeghan O’Connor Jose E. Manautou Richard S. Bruno | 2011 | The Journal of Nutritional Biochemistry2011，，4： | 2 |
| 5 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 6 | 显示文摘 | Park C Park O Ok | 2001 | Polymer2001，42，： | 2 |
| 7 | Complications and Outcome After Acute Stroke: Does Dysphagia Matter?显示文摘 | D.G. Smithard NA O’Neill C. Park J. Morris R. Wyatt R. England D.F. Martin | 1996 | Stroke A Journal of Cerebral Circulation1996，，7： | 2 |
| 8 | The preparation of exfoliated graphite by using microwaves 显示文摘 | KWON O CHOIR S PARK K KWON Y | 2003 | J Ind Eng Chem (Seoul Republic Korea)2003，9，6： | 1 |
| 9 | A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17 显示文摘 | Park H Li Z Yang X O | 2005 | Nat Immunol2005，6，11： | 1 |
| 10 | Angiopoietin-1 reduces VEGF stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1,VCAM-1,and E-Selectin显示文摘 | Kmi I Mnon S O Park S K | 2001 | Circ Res2001，89，6： | 1 |
| 11 | Mercury-induced oxidative stress in tomato seedlings显示文摘 | Cho U H Park J O | 2000 | Plant Science2000，156，： | 1 |
| 12 | A study on sensory characteristics of herb onion Kimchi differing in herb content 显示文摘 | Jung H O Chung D O Park I D | 2002 | Korean Journal of Culinary Research2002，8，： | 1 |
| 13 | Direct competitive enzyme-linked immunosorbent assay for sulfamethazlne显示文摘 | Euna K O Song H Park J H | 2000 | J Vet Med Sci2000，62，： | 1 |
| 14 | Reaction Effect on the Properties of Poly ( ethylene terephthalate ) and Poly(styrene-eo-maleic anhydride) Blends 显示文摘 | Yoon K H Lee H W Park O O | 2000 | Polymer2000，41，： | 1 |
| 15 | Biological nitrogen removal with enhanced phosphate uptake in a sequencing batch reactor using single sludge system显示文摘 | Lee D S Jeon C O Park J M 2001 | 2001 | Wat Res2001，35，16： | 1 |
| 16 | On delay-de pendent robust stability of uncertain neutral systems with interval time-varying delays 显示文摘 | KWON O M PARK J H LEE S M | 2008 | Applied Mathe- matics and Computation2008，203，2： | 1 |
| 17 | SIRT3,mitochon- drial ROS, ageing, and carcinogenesis 显示文摘 | Park S H Ozden O Jiang H | 2011 | Int J Mol Sci2011，12，9： | 1 |
| 18 | Enhanced elec-trical conductivity of polyaniline film by a low mag-netic field显示文摘 | Park J K Kwon O Choi E Y | 2010 | Synth Met2010，160，78： | 1 |
| 19 | Sirt3, mitochondrial ROS, aging, and carcinogenesis 显示文摘 | Park S H Ozden O Jiang H | 2011 | International Journal of Molecular Sciences2011，12，9： | 1 |
| 20 | Exponential stability foruncertain dynamic systems with time-varying delays : an LMIoptimization approach 显示文摘 | Kwon O M Park J H Lee S M | 2008 | Journal of Optimization Theoryand Applications2008，137，3： | 1 |
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