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| 1 | ^(99m)TC-Methylene diphosphonate uptake at injury site correlates with osteoblast differentiation and mineralization during bone healing in mice显示文摘99m Tc-Methylene diphosphonate(99m Tc-MDP) is widely used in clinical settings to detect bone abnormalities.However, the mechanism of99 m Tc-MDP uptake in bone is not well elucidated. In this study, we utilized a mouse tibia injury model, single-photon emission computed tomography(gamma scintigraphy or SPECT),ex vivo micro-computed tomography, and histology to monitor99 m Tc-MDP uptake in injury sites during skeletal healing. In an ex vivo culture system, calvarial cells were differentiated into osteoblasts with osteogenic medium, pulsed with99 m Tc-MDP at different time points, and quantitated for99 m Tc-MDP uptake with a gamma counter. We demonstrated that99 m Tc-MDP uptake in the injury sites corresponded to osteoblast generation in those sites throughout the healing process. The99 m Tc-MDP uptake within the injury sites peaked on day 7 post-injury, while the injury sites were occupied by mature osteoblasts also starting from day 7.99 m Tc-MDP uptake started to decrease 14 days post-surgery, when we observed the highest level of bony tissue in the injury sites. We also found that99 m Tc-MDP uptake was associated with osteoblast maturation and mineralization in vitro. This study provides direct and biological evidence for99 m Tc-MDP uptake in osteoblasts during bone healing in vivo and in vitro. | Zhendong A Zhong Anderson Peck Shihong Li Jeff Van Oss John Snider Casey J Droscha Tingtung A Chang Bart O Williams | 2015 | Bone Research2015，3，2： | 2 |
| 2 | An 18-year experience with the umbrella graft in rhinoplasty显示文摘 | PECK G J MICHELSON L SEGAL J | 1998 | Plast Reconstr Surg1998，102，6： | 1 |
| 3 | Interpretation of drilling parameters for ground characterization in exploration and development of quarries显示文摘 | Scoble M J Carter M | 1987 | Transactions of the Institution of Mining and Metallurgy1987，96，： | 1 |
| 4 | NMR microspec- troscopy using 100 μm planar RF coils fabricated on gallium arsenide substrates 显示文摘 | Peck T L Magin R L Kruse J | 1994 | Ieee Transactions on Bi- omedical Engineering1994，41，7： | 1 |
| 5 | Human RhoGAP domain- containing proteins: structure, function and evolutionary relation- ships显示文摘 | Peck J Douglas G 4th Wu C H | 2002 | FEBS Lett2002，528，13： | 1 |
| 6 | Lithological interpretation based on monitored drilling performance parameters显示文摘 | Peck J Scoble M J | 1991 | CIM Bulletin1991，84，951： | 1 |
| 7 | First order design theory for linearly compensated zoom systems 显示文摘 | Pwgis R J Peck W G | 1962 | J Opt Soc Am1962，52，8： | 1 |
| 8 | Demand uncertainty and returns policies 显示文摘 | Marvel H Peck J | 1995 | International Economic Review1995，36，1： | 1 |
| 9 | The genetics of primary haemorrhagic stroke, subarachnoid haemorrhage and ruptured intracranial aneurysms in adults显示文摘 | Peck G Smeeth L Whittaker J | 2008 | PLoS One2008，3，11： | 1 |
| 10 | Midterm outcome after vertebroplasty: predictive value of technical and patient-related factors显示文摘 | Hodler J Peck D Gilula LA | 2003 | Radiolo- gy2003，227，3： | 1 |
| 11 | Hedonic and utilitarian motivations for online retail shopping behavior 显示文摘 | Childers T L Carr C L Peck J | 2001 | Journal of Retailing2001，77，4： | 1 |
| 12 | Hole doping of the CuO2 chains(La,Sr,Ca)14Cu24 O41显示文摘 | CARTER S A BATLOGG B CAVA R J KRAJEWSKI J J PECK JR W F RICE T M | 1996 | Phys Rev Lett1996，77，7： | 1 |
| 13 | Heave and lateral movements due to pile driving显示文摘 | HAGERTY D J PECK R B | 1971 | Journal of the Soil Mechanics and Foundations Division ASCE1971，97，11： | 1 |
| 14 | Continental climate response to orbital forcing from biogenic silica records in Lake Baikal 显示文摘 | Colman S M Peck J A Karabanov E B | 1995 | Nature1995，378，： | 1 |
| 15 | Use of a novel method to characterize the response of spores of non - proteolytic Clostridium botulinum types B, E and F to a wide range of germinants and conditions 显示文摘 | Plowman J Peck MW | 2002 | J Appli Microbiol2002，92，4： | 1 |
| 16 | MicroRNA expression profiles classify human cancers显示文摘 | LU J Getz G Miska EA Alvarez-Saavedra E Lamb J Peck D Sweet-Cordero A Ebert BL Mak RH Ferrando AA | | 0，，： | 1 |
| 17 | Detection and quantitation of circulation cancer cells in the peripheral blood of lung patients显示文摘 | Peck K Sher Y Shih J | 1998 | Cancer Res1998，58，13： | 1 |
| 18 | Demand Uncertainty and Returns Policies显示文摘 | Marvel H Peck J | 1995 | International Economic Review1995，36，： | 1 |
| 19 | Enhancement of the dielectric constant of Ta2O5 through substitution with TiO2 显示文摘 | CAVA R F PECK W F KRAJEWSKI J J | 1995 | Nature1995，377，6546： | 1 |
| 20 | Supply Chain Risk Management:Outlining an Agenda for Future Research显示文摘 | Jüttner U Peck H Christopher M | | 0，，： | 1 |
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