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| 1 | More synergetic cooperation of Yamanaka factors in induced pluripotent stem cells than in embryonic stem cells显示文摘在 pluripotency 的正式就职的核心管理者最近在体的房间 reprogramming 期间被发现了的 Yamanaka 因素的角色。我们的以前的学习发现 Yamanaka 因素在维持胚胎的茎(ES ) 房间 pluripotency 调整一个发展发信号网络。这里,我们完全证实 reprogrammed 导致了 pluripotent 茎(iPS ) 细胞并且由薄片薄片试金在这些细胞分析了 Yamanaka 因素的全球倡导者占有。我们发现 565 基因的倡导者是由在 iPS 房间的四个 Yamanaka 因素的合作界限, 10 褶层增加什么时候与他们在 ES 房间的绑定相比。,在 ES 房间 Oct4, Sox2,或 Klf4 在 iPS 房间在激活并且镇压的基因同等地散布的一个单个 Yamanaka 因素占据的倡导者在激活的主要在镇压基因和 c-Myc 散布了。薄片薄片数据的小径分析表明 Yamanaka 因素在 iPS 房间, 12 在之中是普通的调整了 16 条发展发信号小径, 4 与在 ES 房间调整的小径相比是唯一的。我们进一步在 iPS 房间分析了另一最近出版的薄片薄片数据集并且观察了类似的结果,显示出为揭示 pluripotency 维护和新生的性质的薄片薄片正小径分析的力量。下次,我们试验性地测试了压抑的发信号小径之一并且发现它的抑制确实改进了房间 reprogramming 的效率。一起拿,我们建议有一个核心为 pluripotency 必要的发展发信号网络与 TGF- ,刺猬, Wnt,是的 p53 压抑(殷) 管理者和 Jak-STAT,房间周期,焦点的粘附, adherens 连接作为活跃(杨) ;并且 Yamanaka 因素 synergistically 在 Yin-Yang 调整他们导致 pluripotency 的平衡方法。 | Jinyan Huang Taotao Chen Xiaosong Liu Jing Jian Jinsong Li Dangsheng Li X Shirley Liu Wei Li Jiuhong Kang Gang Pei | 2009 | Cell Research2009，19，10： | 4 |
| 2 | A multiscale 3D finite element analysis of fluid/solute transport in mechanically loaded bone显示文摘The transport of fluid, nutrients, and signaling molecules in the bone lacunar–canalicular system(LCS) is critical for osteocyte survival and function. We have applied the fluorescence recovery after photobleaching(FRAP) approach to quantify load-induced fluid and solute transport in the LCS in situ, but the measurements were limited to cortical regions 30–50 μm underneath the periosteum due to the constrains of laser penetration. With this work, we aimed to expand our understanding of load-induced fluid and solute transport in both trabecular and cortical bone using a multiscaled image-based finite element analysis(FEA)approach. An intact murine tibia was first re-constructed from micro CT images into a three-dimensional(3D)linear elastic FEA model, and the matrix deformations at various locations were calculated under axial loading. A segment of the above 3D model was then imported to the biphasic poroelasticity analysis platform(FEBio) to predict load-induced fluid pressure fields, and interstitial solute/fluid flows through LCS in both cortical and trabecular regions. Further, secondary flow effects such as the shear stress and/or drag force acting on osteocytes, the presumed mechano-sensors in bone, were derived using the previously developed ultrastructural model of Brinkman flow in the canaliculi. The material properties assumed in the FEA models were validated against previously obtained strain and FRAP transport data measured on the cortical cortex.Our results demonstrated the feasibility of this computational approach in estimating the fluid flux in the LCS and the cellular stimulation forces(shear and drag forces) for osteocytes in any cortical and trabecular bone locations, allowing further studies of how the activation of osteocytes correlates with in vivo functional bone formation. The study provides a promising platform to reveal potential cellular mechanisms underlying the anabolic power of exercises and physical activities in treating patients with skeletal deficiencies. | Lixia Fan Shaopeng Pei X Lucas Lu Liyun Wang | 2016 | Bone Research2016，4，3： | 2 |
| 3 | Haploinsufficiency of p18INK4c sensitizes mice to carcinogen-induced tumorigenesis显示文摘 | BAI F PEI X H VIRGINIA L G | 2003 | Molecular and Cellular2003，23，4： | 1 |
| 4 | Convergence of Electric Bands for High Performance Bulk Thermoelectrics 显示文摘 | Pei Y Shi X LaLonde A | 2011 | Nature2011，473，7345： | 1 |
| 5 | Conjugate heat and mass transfer in membrane-formed channels in all entry regions显示文摘 | Zhang L Z Liang C H Pei L X | 2010 | International Journal of Heat and Mass Transfer2010，53，56： | 1 |
| 6 | 查看详情显示文摘 | Li J Xie W X Pei J H | | 0，，5： | 1 |
| 7 | Efficient skyline and Top-k retrieval in subspaces 显示文摘 | TAO Y XIAO X PEI J | 2007 | IEEE Transactions on Knowledge and Data Engi- neering2007，19，8： | 1 |
| 8 | NADPH oxidase 1-de- pendent ROS is crucial for TLR4 signaling to promote tumor metastasis of non-small celt lung cancer 显示文摘 | Liu X Pei C Yan S | 2015 | Tumour Biol2015，，： | 1 |
| 9 | On OH density of an atmospheric pressure plasma jet by laser-induced fluorescence显示文摘 | Pei X Wu S Xian Y | 2014 | IEEE Transactions on Plasma Science2014，42，5： | 1 |
| 10 | An MAGDM approach combining numerical values with uncertain linguistic information and its appli- cation in evaluation of Rb-D projects显示文摘 | Liu X B Pei F Yang J B | 2010 | International Journal of Computational Intelligence Systems2010，3，5： | 1 |
| 11 | Magnetic and electric bulge-test instrument for the determina- tion of coupling mechanical properties of functional free-standing films and flexible electronics显示文摘 | Yu Z Mao W Li F Feng X Pei Y Fang D | 2014 | Review of Scientific Instrument s2014，85，06： | 1 |
| 12 | Effects of straw mulching on soil temperature,evaporation and yield of winter wheat:field experiments on the North China Plain显示文摘 | CHEN S Y ZHANG X Y PEI D | 2007 | Annals of Applied Biology2007，150，3： | 1 |
| 13 | Investigation on the electrical properties and inhomogeneous distribution of ZnO: Al thin films prepared by dc magnetron sputtering at low deposition temperature显示文摘 | Zhang X B Pei Z L Gong J | 2007 | Journal of Applied Physics2007，101，01： | 1 |
| 14 | Zinc oxide nanorods and their photoluminescence property显示文摘 | Dai Y Zhang Y Pei X M | 2003 | J Wuhan University of Technology2003，18，3： | 1 |
| 15 | Old Age Support in China: The Role of the State and the Family显示文摘 | PEI X M PILLAI V K | 1999 | The International Journal of Aging and Human Development1999，49，3： | 1 |
| 16 | Rosuvastatin at- tenuates monocrotatine-induced pulmonary hyperten- sion via regulation of Akt/eNOS signaling and asym- metric dimethylarginine metabolism显示文摘 | PEI Y Z MA P WANG X | 2011 | Eur J Phar- macol2011，666，： | 1 |
| 17 | Rosuvastatin attenuates monocrotalineinduced pulmonary hypertension via regulation of Akt/eNOS signaling and asymmetric dimethylarginine metabolism显示文摘 | Pei Y Ma P Wang X | | 0，，： | 1 |
| 18 | Cerebroside and ceramide from the pollen of Brassica napus L显示文摘 | Pei D Liu J X Di D L | 2010 | Fitoterapia2010，81，7： | 1 |
| 19 | NADPH oxidase inhibitor DPI is neuroprotective at femtomolar concentrations through inhibition of microglia over-activation 显示文摘 | QIAN L GAO X PEI Z | 2007 | Parkinsonism Relat Disord2007，13，3： | 1 |
| 20 | Synchronization of the noisy electrosensitive cells in the paddlefish显示文摘 | Neiman A Pei X Russell D | 1999 | Phys Rev Lett1999，82，3： | 1 |
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