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| 1 | 氯吡格雷的使用与药物洗脱支架植入后远期临床结果显示文摘背景:近来的冠状动脉内药物洗脱支架研究提示,现行的抗血小板治疗方案可能并不足以预防后期支架内血栓形成。目的:于接受药物洗脱支架(drug-eluting stents,DESs)和裸金属支架(bare-metal stents,BMSs)治疗的冠状动脉病患者中评估氯吡格雷使用与患者远期结果的关系。设计、地点及患者:于连续患者中进行观察性研究。患者于2000年1月1日至2005年7月31日在杜克心脏治疗中心(一家位于北卡罗来纳州达累姆市的三级治疗中心)接受冠状动脉内支架治疗。于6、12、24个月时进行随访,直至2006年9月7日。研究人群包括4666例最初接受BMS(n=3165)或DES(n=1501)经皮冠状动脉介入治疗的患者。对随访6和12个月没有事件(没有死亡、心肌梗死或血管重建手术)的患者进行界标分析(landmark analysis)。在这些时间点上根据支架类型以及自我报告之氯吡格雷的使用情况将患者分为4组:DES使用氯吡格雷组、DES不用氯吡格雷组、BMS使用氯吡格雷组以及BMS不用氯吡格雷组。主要观测指标:随访24个月时死亡、非致命性心肌梗死以及死亡或心肌梗死之复合终点。结果:在6个月时没有事件发生的DES组患者(637例使用、579例未使用氯吡格雷)中,氯吡格雷的使用是随访24个月校正死亡率较低(使用2.0%比未使用5.3%;差异,-3.3%;95%CI,-6.3%至-0.3%;P=0.03)以及死亡或心肌梗死发生率较低(3.1%比7.2%;差异,-4.1%;95%CI,-7.6%至-0.6%;P=0.02)的显著预测指标。然而,在BMS组患者中(417例使用、1976例未用氯吡格雷),死亡(3.7%比4.5%;差异,-0.7%;95%CI,-2.9%至1.4%;P=0.50)以及死亡或心肌梗死发生率(5.5%比6.0%;差异,-0.5%;95%CI,-3.2%至2.2%;P:0.70)没有差异。在12个月随访没有事件发生的DES组患者(252例使用、276例未用氯吡格雷)中,氯吡格雷的使用依然可以预测24个月死亡(0%比3.5%;差异,-3.5%;95%CI,-5.9%至-1.1%;P=0.004)以及死亡或心肌梗死发生率(0%比4.5%;差异,-4.5%;95%CI,-7.1%至-1.9%;P〈0.001)较低。然而,在BMS组患者中(346例使用、1644例未用氯吡格雷),在死亡(3.3%比2.7%;差异,0.6%;95%CI,1.5%至2.8%;P=0.57)以及死亡或心肌梗死(4.7%比3.6%;差异,1.0%;95%CI,-1.6%至3.6%;P=0.44)发生方面,依然没有差异。结论:在接受DES治疗的患者中,延长氯吡格雷的使用可以使死亡以及死亡或心肌梗死的发生率下降。然而,使用氯吡格雷的适宜期限只能通过大型临床随机试验确定。 | Eric L Eisenstein, DBA Kevin J. Anstrom, PhD David F. Kong, MD Linda K. Shaw, MS Robert H. Tuttle, MSPH Daniel B. Mark, MD, MPH Judith M. Kramer, MD, MS Robert A. Harrington, MD David B. Matchar, MD David E. Kandzari, MD 1 Eric D. Peterson, MD, MPH Kevin A. Schulman, MD Robert M. Califf, MD 李呈亿(译) David E. Kandzari, MD | 2007 | 美国医学会杂志(中文版)2007，26，3： | 60 |
| 2 | Rapid Detection of Wheat Blast Pathogen Magnaporthe oryzae Triticum Pathotype Using Genome-Specific Primers and Cas12a-mediated Technology显示文摘Wheat blast,caused by the fungus Magnaporthe oryzae Triticum(MoT)pathotype,is a devastating disease persistent in South America and Bangladesh.Since MoT generally fails to cause visual symptoms in wheat until the heading stage when the infection would have advanced,disease control by fungicide application solely based on the detection of visual symptoms is ineffective.To develop an accurate and sensitive method to detect MoT at the seedling and vegetative stages for disease control,we sequenced the genomes of two MoT isolates from Brazil and identified two DNA fragments,MoT-6098 and MoT-6099,that are present in the MoT genome but not in the genome of the rice-infecting Magnaporthe oryzae Oryzae(MoO)pathotype.Using polymerase chain reaction(PCR),we confirmed the specificity of the two markers in 53 MoT and MoO isolates from South America and Bangladesh.To test the efficiency of the two markers,we first established a loop-mediated isothermal amplification(LAMP)method to detect MoT at isothermal conditions,without the use of a PCR machine.Following this,we used the Cas12a protein and guide RNAs(gRNAs)to target the MoT-6098 and MoT-6099 sequences.The activated Cas12a showed indiscriminate single-stranded deoxyribonuclease(ssDNase)activity.We then combined targetdependent Cas12a ssDNase activation with recombinase polymerase amplification(RPA)and nucleic acid lateral flow immunoassay(NALFIA)to develop a method that accurately,sensitively,and cost-effectively detects MoT-specific DNA sequences in infected wheat plants.This novel technique can be easily adapted for the rapid detection of wheat blast and other important plant diseases in the field. | Houxiang Kang Ye Peng Kangyu Hua Yufei Deng Maria Bellizzi Dipali Rani Gupta Nur Uddin Mahmud Alfredo S.Urashima Sanjoy Kumar Paul Gary Peterson Yilin Zhou Xueping Zhou Md Tofazzal Islam Guo-Liang Wang | 2021 | Engineering2021，7，9： | 4 |
| 3 | Glutamate triggers the expression of functional ionotropic and metabotropic glutamate receptors in mast cells显示文摘Mast cells are emerging as players in the communication between peripheral nerve endings and cells of the immune system.However,it is not clear the mechanism by which mast cells communicate with peripheral nerves.We previously found that mast cells located within healing tendons can express glutamate receptors,raising the possibility that mast cells may be sensitive to glutamate signaling.To evaluate this hypothesis,we stimulated primary mast cells with glutamate and showed that glutamate induced the profound upregulation of a panel of glutamate receptors of both the ionotropic type(NMDAR1,NMDAR2A,and NMDAR2B)and the metabotropic type(mGluR2 and mGluR7)at both the mRNA and protein levels.The binding of glutamate to glutamate receptors on the mast cell surface was confirmed.Further,glutamate had extensive effects on gene expression in the mast cells,including the upregulation of proinflammatory components such as IL-6 and CCL2.Glutamate also induced the upregulation of transcription factors,including Egr2,Egr3 and,in particular,FosB.The extensive induction of FosB was confirmed by immunofluorescence assessment.Glutamate receptor antagonists abrogated the responses of the mast cells to glutamate,supporting the supposition of a functional glutamate–glutamate receptor axis in mast cells.Finally,we provide in vivo evidence supporting a functional glutamate–glutamate receptor axis in the mast cells of injured tendons.Together,these findings establish glutamate as an effector of mast cell function,thereby introducing a novel principle for how cells in the immune system can communicate with nerve cells. | Md Abdul Alim Mirjana Grujic Paul W.Ackerman Per Kristiansson Pernilla Eliasson Magnus Peterson Gunnar Pejler | 2021 | Cellular & Molecular Immunology2021，18，10： | 2 |
| 4 | Acute slipped capital femoral epiphysis:the value and safety of urgent manipulative re- duction显示文摘 | Peterson MD Weiner DS Green NE et 81 | 1997 | J Pediatr Orthop1997，17，5： | 1 |
| 5 | Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients显示文摘 | Jackson RP Peterson MD McManus AC | 1998 | Spine1998，23，16： | 1 |
| 6 | Compensatory spinopelvic balance over the hip axis and better reliability in measuring lordosis to the pelvic radius on standing lateral radiographs of adult volunteers and patients显示文摘 | Jackson RP Peterson MD McManus AC | 1998 | Spine(Phila Pa 1976)1998，23，16： | 1 |
| 7 | Disruption of DNA-PK in Ku80 mutant xrs-6 anti the implications in DNA double-strand break repair显示文摘 | Chen F Peterson SR Story MD | 1996 | Murat Res 1996 Jan 21996，362，1： | 1 |
| 8 | Outcomes of patients presenting with acute type A aortic dissection in the setting of prior cardiac surgery : an analysis from the inter- national registry of acute aortic dissection 显示文摘 | Teman NR Peterson MD Russo MJ | 2013 | Circulation2013，128，111： | 1 |
| 9 | Dynamically evoked,discrete-threshold electromyography in the extreme lateral interbody fusion approach显示文摘 | Tohmeh AG Rodgers WB Peterson MD | 2011 | J Neurosurg Spine2011，31，1： | 1 |
| 10 | Dynamically evoked, discrete-threshold electromyography inextreme lateral interbody fusion approach显示文摘 | Tohmeh AG Rodgers WB Peterson MD | 2011 | J Neurosurg Spine2011，14，1： | 1 |
| 11 | Understand- ing work using the Occupational Information Network (O'NET) : Im- plications for practice and research显示文摘 | PETERSON NG MUMFORD MD BORMAN WC | 2001 | Personnel Psychology2001，54，2： | 1 |
| 12 | Resistance exercise for muscular strength in older adults: a meta - analysis 显示文摘 | Peterson MD Rhea MR Sen A | 2010 | Ageing Res Rev2010，9，3： | 1 |
| 13 | Understanding work using the occupational information network (O * NET)显示文摘 | Peterson NG Mumford MD Borman W C | | 0，，2： | 1 |
| 14 | Understanding work using the occupational information network (O* NET): implications for practice and research 显示文摘 | Peterson NG Mumford MD Borman WC | 2001 | PersonelPsychol2001，54，2： | 1 |
| 15 | Outcomes of patients pres- enting with acute type A aortic dissection in the setting of prior cardiac surgery:an analysis from the International Registry of Acute Aortic Dissection显示文摘 | Teman NR Peterson MD Russo MJ | 2013 | Circulation2013，128，11： | 1 |
| 16 | Abdominal obesity is an independent predictor of serum 25-hydroxyvitamin D deficien- cy in adults with cerebral palsy 显示文摘 | Peterson MD Haapala HJ Chaddha A | 2014 | Nutr Metab(Lond)2014，11，： | 1 |
| 17 | Instrumented posterolateral lumbar fusion: results and comparison with interbody lumbar fusion显示文摘 | Greenough CG Peterson MD Hadlow S | 1998 | Spine1998，23，： | 1 |
| 18 | Evidence for lateral gene transfer between Archaea and bacteria from genome sequence of Thermotoga maritime 显示文摘 | Nelson KE Clayton RA Gill SR Gwinn ML Dodson RJ Haft DH Hickey EK Peterson JD Nelson WC Ketchum KA McDonald L Utterback TR Malek JA Linher KD Garrett MM Stewart AM Cotton MD Pratt MS Phillips CA Richardson D Heidelberg J Sutton GG Fleischmann RD Eisen JA White O Salzberg SL Smith HO Craig Venter J Fraser CM | 1999 | Nature1999，399，： | 1 |
| 19 | Dynamically e?voked, discrete -threshold electromyography in the extreme lateral interbody fusion approach 显示文摘 | Tohmeh AG Rodgers WB Peterson MD | 2011 | J Neurosurg Spine2011，14，1： | 1 |
| 20 | Monocyte adhesion to xenogeneic endothelium during laminar flow is dependent on alpha-Gal-mediated monocyte activation 显示文摘 | Peterson MD Jin R Hyduk S | 2005 | J Immunol2005，174，12： | 1 |
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