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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Ni EXAFS studies of the Ni-Mo S structure in carbon-supported and alumina-supported Ni-Mo catalysts显示文摘 | Louwers S P A Prins R | 1992 | J Catal1992，133，1： | 1 |
| 3 | An EXAFS study on the Ni and W environment in carbon-supported,sulfided W and Ni-W cata lysts显示文摘 | Louwers S P A Prins R | 1993 | J Catal1993，139，2： | 1 |
| 4 | Hemodynamie instability in sepsis :bedside assessment by Doppler echoeardiosraphy显示文摘 | Vieillard-Baron A Prin S Chergui K | 2003 | Am J Resp Crit Care Med2003，168，： | 1 |
| 5 | Calphad显示文摘 | Prins S N Cornish L A Stumpf W E | 2003 | 27(1):792003，27，1： | 1 |
| 6 | Crystalline host phases for actinides, obtained by self-propagating high-temperature synthesis显示文摘 | GLAGOVSKII E M YUDINTSEV S V KU- PRIN A V | 2001 | Radionehemistry2001，43，6： | 1 |
| 7 | The Late Quaternary sedimentary record on Reykjanes Ridge (North Atlantic)显示文摘 | PRINS M A TROELSTRA S R KRUK R W | 2001 | Radiocarbon2001，43，2： | 1 |
| 8 | Late Quaternary sedimentary processes and ocean circulation changes at the Southeast Greenland Margin显示文摘 | KUIJPERS A TROELSTRA S R PRINS M A | 2003 | Marine Geology2003，195，： | 1 |
| 9 | Biomass gasification in near- and super-critical water: Status and prospects显示文摘 | MASTUMURA Y MINOWA T POTIC B KERSTEN S R A PRINS W | 2005 | Biomass Bioenergy2005，29，10： | 1 |
| 10 | Independent effects of diet and exercise training on fat oxidation in non-alcoholic fatty liver disease显示文摘AIM To investigate the independent effects of 6-mo of dietary energy restriction or exercise training on wholebody and hepatic fat oxidation of patients with nonalcoholic fatty liver disease(NAFLD).METHODS Participants were randomised into either circuit exercise training(EX;n = 13;3 h/wk without changes in dietary habits),or dietary energy restriction(ER) without changes in structured physical activity(ER;n = 8).Respiratory quotient(RQ) and whole-body fat oxidation rates(Fatox) were determined by indirect calorimetry under basal,insulin-stimulated and exercise conditions.Severity of disease and steatosis was determined by liver histology;hepatic Fatox was estimated from plasma β-hydroxybutyrate co.ncentrations;cardiorespiratory fitness was expressed as VO2 peak.Complete-case analysis was performed(EX:n = 10;ER:n = 6).RESULTS Hepatic steatosis and NAFLD activity score decreased with ER but not with EX.β-hydroxybutyrate concentrations increased significantly in response to ER(0.08 ± 0.02 mmol/L vs 0.12 ± 0.04 mmol/L,P = 0.03) but remained unchanged in response to EX(0.10 ± 0.03 mmol/L vs 0.11 ± 0.07 mmol/L,P = 0.39).Basal RQ decreased(P = 0.05) in response.to EX,while this change was not significant after ER(P = 0.38).VO_(2peak)(P < 0.001) and maximal Fa_(tox) during aerobic exercise(P = 0.03) improved with EX but not with ER(P > 0.05).The increase in β-hydroxybutyrate concentrations was correlated with the reduction in hepatic steatosis(r =-0.56,P = 0.04).CONCLUSION ER and EX lead to specific benefits on fat metabolism of patients with NAFLD.Increased hepatic Fat_(ox) in response to ER could be one mechanism through which the ER group achieved reduction in steatosis. | Ilaria Croci Nuala M Byrne Veronique S Chachay Andrew P Hills Andrew D Clouston Trisha M O'Moore-Sullivan Johannes B Prins Graeme A Macdonald Ingrid J Hickman | 2016 | World Journal of Hepatology2016，8，27： | 1 |
| 11 | Structure of molybdenum sulfide in carbon supported Mo and CoMo sulfide catalysts as studied by extended X-ray absorption fine structure spectroscopy显示文摘 | Bouwens S M A M Prins R de Beer V H J | 1990 | J Phys Chern1990，94，： | 1 |
| 12 | The risk of abortion and stillbirth in antithrombin-, protein C-, and protein S-deficient women显示文摘 | Sanson BJ Friederich PW Simioni P Zanardi S Hilsman MV Girolami A ten Cate JW Prins MH | 1996 | Thrombosis and Haemostasis1996，75，3： | 1 |
| 13 | Fire retardant mechanism of aliphatic bromine compounds in polystyrene and poly- propylene 显示文摘 | Kaspersma J Doumen C Munro S Prins A M | 2002 | Polymer Degradation Stability2002，77，2： | 1 |
| 14 | Increasing respiratory rate to improve CO2 clearance during mechanical ventilation is not a panacea in acute respiratory failure显示文摘 | Prin S Augarde R | 2002 | Crit Care Med2002，30，： | 1 |
| 15 | Genetic analysis of three US population groups using an X-chromosomal STR decaplex显示文摘 | GOMES I PRIN ZM PEREIRA R MEYERS C MIKULASOVICH R S AMORIM A CARRACEDO A GUSMAO L | 2007 | Int J Legal Med2007，121，3： | 1 |
| 16 | Silent brain infarcts and the risk of dementia and cognitive decline显示文摘 | Vermeer S E Prins N D den Heijer T Hofman A Koudstaal P J Breteler M M | 2003 | N Engl J Mect2003，348，： | 1 |
| 17 | Hemodynamie instability in sepsis: Bedside assess-Ment by Doppler echocardiography显示文摘 | Vieillard-Baron A Prin S Chergui K | 2003 | Am J Respir Crit Care Ned2003，168，： | 1 |
| 18 | Formation of mesopores in zeolite beta by steaming: A secondary pore channel system in the (001) plane显示文摘 | BERNASCONI S VAN BOKHOVEN J A KRUMEICH F PIRNGRUBER G D PRINS R | 2003 | Microporous Mesoporous Mater2003，66，1： | 1 |
| 19 | Characterisation of catalysts used in wall reactors for the catalytic dehydrogenation of methylcyclohexane显示文摘 | TSCHUDIN S SHIDO T PRINS R WOKAUN A | 1999 | J Catal1999，181，1： | 1 |
| 20 | Diet and habitat-niche relationships within an assemblage of large herbivores in a seasonal tropical forest显示文摘 | Ahrestani F S Heitk6nig I M A Prins H H T | 2012 | Journal of Tropical Ecology2012，28，4： | 1 |
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