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| 1 | 体内腺相关病毒-常间回文重复序列丛集及其相关蛋白9介导的基因编辑可改善家族性高胆固醇血症的动脉粥样硬化显示文摘低密度脂蛋白受体(low-density lipoprotein receptor,Ldlr)基因突变是家族性高胆固醇血症的主要原因之一,可导致动脉粥样硬化,并具有很高的终生心血管病风险。常间回文重复序列丛集(clustered regularly interspaced short palindromic repeats,CRISPR)/CRISPR相关蛋白9(CRISPR-related protein 9,Cas9)系统是基因编辑纠正基因突变从而改善疾病的有效工具。该研究的目的是通过腺相关病毒(adeno-associated virus,AAV)携带的CRISPR/Cas9系统进行体内体细胞基因编辑,以确定其能否在小鼠模型中治疗由Ldlr突变体引起的家族性高胆固醇血症。 | 刘青(译) 叶鹏(审校) Zhao H Li Y He L Pu W Yu W Li Y Wu YT Xu C Wei Y Ding Q Song BL Huang H Zhou B | 2020 | 中华高血压杂志2020，28，3： | 22 |
| 2 | Evaluation of combination gene therapy with PTEN and antisense hTERT for malignant glioma in vitro and xenografts显示文摘 | You, Y. P. Geng, X. Z. Zhao, P. FU, Z. Wang, C. Z. Chao, S. W. Liu, N. Lu, A. L. Gardner, K. Pu, P. Y. Kong, C. S. Ge, Y. Judge, S. I. V. Li, Q. D. Q | 2007 | 南京医科大学学报(自然科学版)2007，27，5： | 6 |
| 3 | A new disease in rabbits显示文摘 | Liu S J Xue H P Pu B Q | 1984 | Anima Husb Vet Med1984，16，： | 1 |
| 4 | 2-Mercaptobenzothiazole-bonded silica gel as selective adsorbent for preconcentration of gold, platinum and palladium prior to their simultaneous inductively coupled plasma optical emission spectrometric determination显示文摘 | Pu Q S Su Z X Hu Z D | 1998 | J At Anal Spectrom1998，13，4： | 1 |
| 5 | Effects of Different Bismuth-based Compounds Additives on the Positive Temperature Coefficient Effect of BaTiO3 Ceramics 显示文摘 | Yuan Q B Pu Y P | 2012 | Materials Letters2012，6，： | 1 |
| 6 | Freeze-drying of human red blood cells: influence of carbohydrates and their concentrations显示文摘 | Yu Jianping Liu J H Pu L Q Cui Xiangdong Wang Changzheng Ouyang S L Gao Dayong | 2004 | Cell Preservation Technology2004，2，4： | 1 |
| 7 | Effect of crossing over hypertensive patients from a beta-blocker to an angiotensin receptor antagonist on resistance artery structure on endothelial function显示文摘 | Schiffrin EL Park JB Pu Q | 2002 | J Hypertens2002，20，2： | 1 |
| 8 | Application of2-mercaptobenzothiazole-modified silica gel to online preconcentration and separation of silver for its atomic absorption spectrometric determination显示文摘 | Pu Q S Sun Q Y Hu Z D | 1998 | Analyst1998，123，2： | 1 |
| 9 | GATA4 is adosage-sensitive regulator of cardiac morphogenesis显示文摘 | Pu WT Ishiwata T Juraszek AL Ma Q Izumo S | 2004 | Dev Biol2004，275，1： | 1 |
| 10 | Endothelin antagonism on aldosterone-induced oxidative stress and vascular remodeling显示文摘 | Pu Q Neves MF Virdis A | 2003 | Hypertension2003，42，： | 1 |
| 11 | Interference-free determination of trace gold and palladium in geological and metallurgical samples by flame atomicabsorption spectrometry coupled with flow injection on-line microcolumn preconcentration and separation system with 2-mercaptopyrimidine immobilized silica gel as microcolumn packing显示文摘 | Liu P Pu Q S Sun Q Y | 2003 | J AOAC Int2003，86，4： | 1 |
| 12 | Combustion synthesis of graphene oxide-TiO2 hybrid materials for photodegradation of methyl orange 显示文摘 | Gao Y Y Pu X P Zhang D F Ding G Q Shao X Ma J | 2012 | Carbon2012，50，： | 1 |
| 13 | Changes of climate, glaciers and runoff in China's monsoonal temperate glacier region during the last several decades显示文摘 | Li Z X He Y Q Pu T | 2010 | Quaternary International2010，218，1： | 1 |
| 14 | Differential role of nitric oxide pathway and heat shock protein in preconditioning and lipopolysaccharide-induced brain ischemic tolerance显示文摘 | Puisieux F Deplanque D Pu Q | 2000 | Eur J Pharmacol2000，389，1： | 1 |
| 15 | Growth and characterization of InGaN blue LED structure on Si (111)by MOCVD显示文摘 | Mo C L Fang W Q Pu Y | 2005 | JCrystGrowth2005，285，： | 1 |
| 16 | Crystal orientation, toug- hening mechanisms and a mimic of nacre 显示文摘 | Feng Q L Cui F Z Pu G | 2000 | Mater Sci Eng C2000，11，： | 1 |
| 17 | A new viral disease in rabbit显示文摘 | LIU S J XUE H P PU B Q | 1984 | AnimHusb Vet Med1984，16，： | 1 |
| 18 | Hydrophilicmodification of poly (ether sulfone) ultrafiltration membranesurface by self-assembly of T1O2 nanoparticles 显示文摘 | Luo M L Zhao J Q Tang W Pu C S | 2005 | Applied Surface Science2005，249，： | 1 |
| 19 | Preparation of aligned porous chitin nanowhisker foams by directional freeze-casting technique显示文摘 | Zhou Y M Fu S Y Pu Y Q | 2014 | Carbohydr Polym2014，2，： | 1 |
| 20 | A Ca^2+ signal is found up stream of cytochrome crelease during apoptosis in HeLa cells显示文摘 | Pu Y Luo K Q Chang D C | 2002 | Biochem Biophys Res Commun2002，299，5： | 1 |
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