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| 1 | Non-ST elevation acute coronary syndrome in the elderly显示文摘1 Introduction Societies are ageing at an accelerated pace.This scenario is a well-known challenge for health care systems,as chronic diseases,multiple comorbidities and dependency are all entities that often converge in the elderly.Besides,there is an issue regarding a reduction in the general incidence of acute coronary syndrome(ACS)together with a delayed in the age of presentation,which,in sum,lead to an increase in both incidence and prevalence of ACS with age,especially non-ST elevation myocardial infarction(NSTEMI). | Pablo Díez-Villanueva César Jiménez Méndez Fernando Alfonso | 2020 | Journal of Geriatric Cardiology2020，17，1： | 4 |
| 2 | Addition of statins to the standard treatment in patients with cirrhosis:Safety and efficacy显示文摘This review summarizes the safety and efficacy of statins in patients with cirrhosis.Due to concerns about the safety of statins in patients with impaired liver function,they have recently been investigated as a potential treatment option in cirrhosis.The most clinically significant adverse event is statin-related myopathy,and this may be related to the high serum statin concentrations in the setting of severely impaired liver function.Rhabdomyolysis is the most serious and potentially life-threatening manifestation.It has recently been demonstrated that the recommended dose of simvastatin in patients with decompensated cirrhosis would be 20 mg/d because higher values,such as 40 mg/d,are associated with many adverse events,especially muscle injury.Likewise,simvastatin should not be administered to patients with Model for End-stage Liver Disease score>12 and/or Child-Pugh class C because of the high risk of severe muscle injury.Due to the pleiotropic effects,the focus on statins has shifted from being considered harmful to something useful.Through these effects,statins could prevent liver-related morbidity and mortality in cirrhotic patients.Observational studies in large populations of patients with cirrhosis have shown that treatment with statins to decrease high cholesterol levels was associated with a reduced risk of hepatic decompensation,hepatocellular carcinoma development and death.The few randomized controlled trials in patients with cirrhosis and portal hypertension showed that statins lower portal pressure,quite likely through a reduction in hepatic resistance.Another large randomized controlled trial in patients with variceal bleeding showed that simvastatin in addition to standard of care did not prevent rebleeding but improved survival rate.Despite these encouraging outcomes,the quality of the evidence regarding the use of statins is low or very low due to the observational characteristics of most of the studies involved.Therefore,it is advisable to perform further randomized controlled trials on a large series of patients with hard clinical endpoints,using different statin types and varying doses.The objectives would be to prevent liver-related morbidity and mortality rather than treating cirrhosis complications to take additional information that makes it possible to add statins to the standard of care of these patients. | Alberto E Muñoz Florencia D Pollarsky Mónica Marino Mariano Cartier Horacio Vázquez Pablo Salgado Gustavo Romero | 2021 | World Journal of Gastroenterology2021，27，28： | 4 |
| 3 | Effect of glucose oxidase,transglutaminase,and pentosanase on wheat proteins:Relationship with dough properties and bread-making quality显示文摘 | Eugenia S M Pablo D R | 2010 | Journal of Cereal Science2010，51，3： | 1 |
| 4 | Environmental Life-cycle Assessment of Transit Buses with Alternative Fuel Technology显示文摘 | Elaine C M Pablo L D | | 0，，： | 1 |
| 5 | Association between bone mineral density and C-reactive protein in a large population-based sample显示文摘 | De PABLO P COOPER M S BUCKLEY C D | 2012 | Arthritis Rheum2012，64，8： | 1 |
| 6 | Weed seeds identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Pablo F Verdes | 2002 | Computers and Electronics in Agriculture2002，33，2： | 1 |
| 7 | Large-scale investigation of weed seed identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Ceccatto H Alejandro | 2005 | Computers and Electronics in Agriculture2005，47，1： | 1 |
| 8 | A new search algorithm for QSPR/QSAR theories:normal boiling points of some organic molecules显示文摘 | Pablo R D Eduardo A C Francisco M F | 2005 | Chemical Physics Letters2005，412，： | 1 |
| 9 | Morphological Control for High Performance, Solution-Processed Planar Herterojunc-tion Perovskite Solar Cells显示文摘 | Giles E Victor M B Pablo D | 2014 | Advanced Functional Materials2014，24，1： | 1 |
| 10 | Ruthenium-catal- ysed asymmetric transfer hydrogenation of N-(tert-hu- tanesulfinyl) imines显示文摘 | GUIJARRO D PABLO O YUS M | 2009 | Tetrahedron Lett2009，50，38： | 1 |
| 11 | Effects of seeding and amounts of Y2O3 : Al2O3 additives on grain growth in Si3N4 ceramics 显示文摘 | Belmonte M Pablos D L Osendi M I | 2008 | Materials Science and Engineering A2008，475，12： | 1 |
| 12 | Evaluation of corn grain yield and water use efficiency using subsurface drip irrigation 显示文摘 | Pablo R G O'Neill M K McCaslin B D | 2007 | Journal of Sustainable Agriculture2007，30，1： | 1 |
| 13 | Shooting Seismic Surveys in Circles 显示文摘 | Buia M Flores Pablo E Hill D | 2008 | Oilfield Review2008，20，3： | 1 |
| 14 | Analysis of the breast cancer survival in a public hospital during the period 1999-2008显示文摘 | Colina Ruizdelgado F Pilas Pérez M Lora Pablos D | 2012 | Rev Esp Salud Publica2012，86，6： | 1 |
| 15 | Free volume and finite-size effects in a polymer glass under stress 显示文摘 | Riggleman R A Lee H N Ediger M D de Pablo J J | 2007 | Physical Review Letters2007，99，21： | 1 |
| 16 | Evaluation of corn grain yield and water use efficiency using subsurface drip irrigation显示文摘 | Pablo R G O'Neill M K McCaslin B D | 2007 | Journal of Sustainable Agriculture2007，30，1： | 1 |
| 17 | Microstructure and mechanical properties of silicon nitride materials fabricated from SHS powders显示文摘 | PABLOS A D BRRMUDO J OSENDI M I | 2001 | J Am Ceram Soc2001，84，5： | 1 |
| 18 | Interpretation of gas-in-oil analysis using new IEC publication 60599 and IEC TCIO databases 显示文摘 | DUVAL M PABLO A D | 2001 | IEEE Electrical Insulation Maeazine2001，，2： | 1 |
| 19 | Weed seeds identification by machine vision显示文摘 | Pablo M Granitto Hugo D Navone Pablo F Verdes | 2002 | Computers and Electronics in Agriculture2002，33，2： | 1 |
| 20 | Microstructure and mechanical properties of silicon nitride materials fabricated from SHS powders显示文摘 | PABLOS A D BERMUDO J OSENDI M I | 2001 | J Am Ceram Soc2001，84，5： | 1 |
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