|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Hypothalamic-pituitary-adrenal axis function during perinatal depression显示文摘Abnormal function of the hypothalamic–pituitary–adrenal(HPA) axis is an important pathological finding in pregnant women exhibiting major depressive disorder. They show high levels of cortisol proinflammatory cytokines, hypothalamic-pituitary peptide hormones and catecholamines, along with low dehydroepiandrosterone levels in plasma. During pregnancy, the TH2 balance together with the immune system and placental factors play crucial roles in the development of the fetal allograft to full term. These factors, when altered, may generate a persistent dysfunction of the HPA axis that may lead to an overt transfer of cortisol and toxicity to the fetus at the expense of reduced activity of placental 11β-hydroxysteroid dehydrogenase type 2. Epigenetic modifications also may contribute to the dysregulation of the HPA axis. Affective disorders in pregnant women should be taken seriously, and therapies focused on preventing the deleterious effects of stressors should be implemented to promote the welfare of both mother and baby. | Phillipe Leff Gelman Mónica Flores-Ramos Margarita López-Martínez Carlos Cruz Fuentes Juan Pablo Reyes Grajeda | 2015 | Neuroscience Bulletin2015，31，3： | 6 |
| 2 | Fecal immunochemical test accuracy in average-risk colorectal cancer screening显示文摘AIM:To assess the fecal immunochemical test(FIT)accuracy for colorectal cancer(CRC)and advanced neoplasia(AN)detection in CRC screening.METHODS:We performed a multicentric,prospective,double blind study of diagnostic tests on asymptomatic average-risk individuals submitted to screening colonoscopy.Two stool samples were collected and the fecal hemoglobin concentration was determined in the first sample(FIT1)and the highest level of both samples(FITmax)using the OC-sensor.Areas under the curve(AUC)for CRC and AN were calculated.The best FIT1and FITmax cut-off values for CRC were determined.At this threshold,number needed to scope(NNS)to detect a CRC and an AN and the cost per lesion detected were calculated.RESULTS:About 779 individuals were included.An AN was found in 97(12.5%)individuals:a CRC in 5(0.6%)and an advanced adenoma(≥10 mm,villous histology or high grade dysplasia)in 92(11.9%)subjects.For CRC diagnosis,FIT1 AUC was 0.96(95%CI:0.95-0.98)and FITmax AUC was 0.95(95%CI:0.93-0.97).For AN,FIT1 and FITmax AUC were similar(0.72,95%CI:0.66-0.78 vs 0.73,95%CI:0.68-0.79,respectively,P=0.34).Depending on the number of determinations and the positivity threshold cut-off used sensitivity for AN detection ranged between 28%and 42%and specificity between 91%and 97%.At the best cut-off point for CRC detection(115 ng/mL),the NNS to detect a CRC were 10.2 and 15.8;and the cost per CRC was 1814€and 2985€on FIT1 and FITmax strategies respectively.At this threshold the sensitivity,NNS and cost per AN detected were 30%,1.76,and 306€,in FIT1 strategy,and 36%,2.26€and 426€,in FITmax strategy,respectively.CONCLUSION:Performing two tests does not improve diagnostic accuracy,but increases cost and NNS to detect a lesion. | Vicent Hernandez Joaquin Cubiella M Carmen Gonzalez-Mao Felipe Iglesias Concepción Rivera M Begoa Iglesias Lucía Cid Ines Castro Luisa de Castro Pablo Vega Jose Antonio Hermo Ramiro Macenlle Alfonso Martínez-Turnes David Martínez-Ares Pamela Estevez Estela Cid M Carmen Vidal Angeles López-Martínez Elisabeth Hijona Marta Herreros-Villanueva Luis Bujanda Jose Ignacio Rodriguez-Prada the COLONPREV study investigators | 2014 | World Journal of Gastroenterology2014，20，4： | 4 |
| 3 | MeSH pesticide trace analysis using solid-phase extraction and gas chromatography with electron capture and tandem mass spectrometric detection in water samples显示文摘 | Martinez Vidal J L Pablos Espada M C Garrido Frenich A | | Jounal of Chromatography A0，，： | 2 |
| 4 | E6 molecular variants of human papillomavirus (HPV) type 16: An updated and unified criterion for clustering and nomenclature显示文摘 | Antonio Huertas-Salgado Diana C. Martín-Gámez Pablo Moreno Raúl Murillo María Mercedes Bravo Luisa Villa Mónica Molano | 2010 | Virology2010，，： | 2 |
| 5 | Environmental Life-cycle Assessment of Transit Buses with Alternative Fuel Technology显示文摘 | Elaine C M Pablo L D | | 0，，： | 1 |
| 6 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 7 | Effects of valsartan and amlodipine on intrarenal hemodynamics and TGF-β1 plasma levels in a crossover trial in renal transplant recipients显示文摘 | Pablo I Josep M Campistol S L | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 8 | Multi-element analysis of tea beverages by inductively coupled plasma atomic emission spectrometry显示文摘 | Ferna'ndez P L Pablos F Martin M J | 2002 | Food Chemistry2002，76，： | 1 |
| 9 | Effects of window size and thermal mass on building comfort using an intelligent ventilation controller显示文摘 | Pablo L R Murray M | 2004 | Solar Energy2004，77，： | 1 |
| 10 | Effects of seeding and amounts of Y2O3 : Al2O3 additives on grain growth in Si3N4 ceramics 显示文摘 | Belmonte M Pablos D L Osendi M I | 2008 | Materials Science and Engineering A2008，475，12： | 1 |
| 11 | An evaluation of the 30s chair stand test in older adults:frailty detection based on kinematic parameters from a single inertial unit显示文摘 | Nora M Pablo L Marisol G | 2013 | J Neuro- eng Rehabil2013，10，1： | 1 |
| 12 | Simultaneous Extraction and Determination of Anionic Surfactants in Waters and Sediments 显示文摘 | PABLO A L ABELARDO G P EDUARDO G M | 2006 | J Chromatogr A2006，1114，2： | 1 |
| 13 | A theoretical study of Gemini surfactant phase behavior显示文摘 | Kristine M L Pablo G DeDenedetti Robert K P | 1998 | Journal of Chemical Physics1998，109，13： | 1 |
| 14 | A simple dot- blot- Sirius red- based assay for collagen quantification显示文摘 | Rodriguez- Rodriguez P Arribas S M L6pez de Pablo A L | 2013 | Analytical and Bioanalytical Chemistry2013，405，： | 1 |
| 15 | Density--functional method for nonequilibrium electron transport显示文摘 | Brandbyge M Mozos J L Pablo O | 2002 | Phys Rev B2002，，： | 1 |
| 16 | Photosynthetic plasticity of Nothofagus pumilio seedlings to light intensity and soil moisture 显示文摘 | GUILLERMO M P MARIA V L PABLO L P | 2007 | Forest Ecology and Management2007，243，： | 1 |
| 17 | A roset technicalnote: Estimating aboveground plant biomass using a photographic technique显示文摘 | Jose M P Williamk L A Pablo | 2000 | Journal of Range Manage2000，53，： | 1 |
| 18 | Study of catechin and xanthine tea profiles as geographical tracers 显示文摘 | Fernmdez P L Pablos F Martin M J | 2002 | Journal of Agricultural and Food Chemistry2002，50，7： | 1 |
| 19 | A simple dot-blot- Sirius red-based assay for collagequantifi- cation显示文摘 | Rodriguez-Rodriguez P Arribas S M Lopez de Pablo A L | 2013 | Analytical and Bioanalytical Chemistry2013，405，： | 1 |
| 20 | Cup-to-disk ratio asymmetry: diagnostic value in glaucoma显示文摘 | Polo Llorens V Larrosa Poves J M Pablo Julvez L E | 2002 | Arch Soc Esp Oftalmol2002，77，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员