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| 1 | Management of Helicobacter pylori infection in Latin America: A Delphi technique-based consensus显示文摘AIM: To optimize diagnosis and treatment guidelines for this geographic region, a panel of gastroenterologists, epidemiologists, and basic scientists carried out a structured evaluation of available literature.METHODS: Relevant questions were distributed among the experts, who generated draft statements for consideration by the entire panel. A modified three-round Delphi technique method was used to reach consensus. Critical input was also obtained from representatives of the concerned medical community. The quality of the evidence and level of recommendation supporting each statement was graded according to United States Preventive Services Task Force criteria.RESULTS: A group of ten experts was established. The survey included 15 open-ended questions that were distributed among the experts, who assessed the articles associated with each question. The levels of agreement achieved by the panel were 50% in the first round, 73.3% in the second round and 100% in the third round. Main consensus recommendations included:(1) when available, urea breath and stool antigen test(HpSA) should be used for non-invasive diagnosis;(2) detect and eradicate Helicobacter pylori(H. pylori) in all gastroscopy patients to decrease risk of peptic ulcer disease, prevent o retard progression in patients with preneoplastic lesions, and to prevent recurrence in patients treated for gastric cancer;(3) further investigate implementation issues and health outcomes of H. pylorieradication for primary prevention of gastric cancer in high-risk populations;(4) prescribe standard 14-d triple therapy or sequential therapy for first-line treatment;(5) routinely assess eradication success post-treatment in clinical settings; and(6) select second- and third-line therapies according to antibiotic susceptibility testing.CONCLUSION: These achievable steps toward better region-specific management can be expected to improve clinical health outcomes. | Antonio Rollan Juan Pablo Arab M Constanza Camargo Roberto Candia Paul Harris Catterina Ferreccio Charles S Rabkin Juan Cristóbal Gana Pablo Cortés Rolando Herrero Luisa Durán Apolinaria García Claudio Toledo Alberto Espino Nicole Lustig Alberto Sarfatis Catalina Figueroa Javier Torres Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，31： | 2 |
| 2 | Effect of glucose oxidase,transglutaminase,and pentosanase on wheat proteins:Relationship with dough properties and bread-making quality显示文摘 | Eugenia S M Pablo D R | 2010 | Journal of Cereal Science2010，51，3： | 1 |
| 3 | Full scale self-propulsion computations using discretized propeller for the kriso eontainer ship KCS 显示文摘 | ALEJANDRO M C PABLO M C FREDERICK S | 2011 | Computers & Fluids2011，51，： | 1 |
| 4 | Characteristics,management and response to alteplase in China versus non-China participants of the ENCHANTED trial显示文摘Background The characteristics of patients with acute ischaemic stroke(AIS)and their management vary across regions,which may influence outcomes.We examined for differential patterns of outcome between China and non-China participants of the ENhanced Control of Hypertension And Thrombolysis strokE stuDy(ENCHANTED),which tested different alteplase doses in AIS.Methods ENCHANTED was an international,multicentre,open,blinded-endpoint trial of the effects of low-dose(0.6 mg/kg)versus standard-dose(0.9 mg/kg)intravenous alteplase on 90-day disability outcomes and symptomatic intracerebral haemorrhage(sICH)in 3310 patients with AIS.Results Participants(n=1419,48%)in China were younger,and more often male,hypertensive and with prior stroke and coronary artery disease,but less likely to have atrial fibrillation and use antihypertensive,antithrombotic and lipid-lowering agents,compared with non-China patients with AIS.Although China participants had more AIS due to large artery occlusion,were treated later and had differing ancillary management,there was no significant difference in 90-day modified Rankin scale scores 2–6(55.6% vs 47.8%;OR,adjusted for baseline and management factors 0.87(95%CI 0.71 to 1.07;p=0.20))and risk of sICH(Safe Implementation of Thrombolysis in Stroke-Monitoring Study criteria:1.4% vs 1.8%;p=0.12)compared with non-China participants.There was no heterogeneity in the treatment effects of low-dose versus standard-dose alteplase between China and non-China participants.Conclusion Patients with AIS recruited to the ENCHANTED trial in China had similar outcomes in response to thrombolysis treatment despite significantly differing demographic,clinical and management factors to patients with AIS in other regions. | Lily Song Xia Wang Thompson Robinson Richard I Lindley Hisatomi Arima Pablo M Lavados Xiaoying Chen John Chalmers Craig S Anderson | 2017 | Stroke & Vascular Neurology2017，2，2： | 1 |
| 5 | A model of market power in electricity industries subject to peak load pricing显示文摘 | Arellano M S Pablo S | 2007 | Energy Policy2007，35，： | 1 |
| 6 | Transmissionimaging polarimetry for a linear birefringent medium using acarrier fringe method 显示文摘 | Drobczynski S Bueno J M Artal Pablo | 2006 | Applied Optics2006，45，22： | 1 |
| 7 | Com- putations of self-ropulsion free to sink and trim and of motions in head waves of the KRISO container ship (KCS) model 显示文摘 | PABLO M C FU HUIPING FREDERICK S | 2011 | Applied Ocean Research2011，33，： | 1 |
| 8 | Association between bone mineral density and C-reactive protein in a large population-based sample显示文摘 | De PABLO P COOPER M S BUCKLEY C D | 2012 | Arthritis Rheum2012，64，8： | 1 |
| 9 | Transcatheter aortic valve implantation in very elderly patients: immediate results and medium term follow-up显示文摘ObjectiveTo 评估立即的 transcatheter 在有严重、征兆的大动脉的狭窄的很老的病人的大动脉的阀门培植(TAVI ) 结果和中期的后续(作为).MethodsThis multicenter,观察、未来的学习在三所医院里被执行。我们包括了连续很老(>85 年) 病人与作为严重由 TAVI 对待。主要端点是在包括的二 years.ResultsThe 研究从任何原因评估死亡率有一个平均数的 160 个连续病人 87 ± 变老;2.1 年(从 85 ~ 94 年的范围) 和 18.8%± 的吝啬的逻辑 EuroSCORE;11.2% 与 57 (35.6%) 病人得分 ≥20% 。程序的成功率是 97.5% ,与 25 (15.6%) 与主要流血经历尖锐复杂并发症的病人(最经常) 。全球死亡率在住院期间是 8.8%(n = 14 ) 并且 30 天的死亡率是 10%(n = 16 ) 。中部在时期上面列在后面是 252.24 ±232.17 天。在后续时期期间, 28 (17.5%) 病人们死了(他们中的 17 个由于心脏的原因) 。估计的二年全面、心脏的幸存率使用 Kaplan-Meier 方法分别地是 71% 和 86.4% 。比例的危险回归给看了的考克斯可变 EuroSCORE ≥20 是与全面 mortality.ConclusionsTAVI 联系的唯一的变量在很老的病人的一张选择人口安全、有效。我们的调查结果支持在病人的这个复杂的组的这个新过程的采纳。 | Isaac Pascual Antonio J Mu oz-García Diego López-Otero Pablo Avanzas Manuel F Jimenez-Navarro Belén Cid-Alvarez Raquel del Valle Juan H Alonso-Briales Raimundo Ocaranza-Sanchez José M Hemández Ramiro Trillo-Nouche César Morís | 2015 | Journal of Geriatric Cardiology2015，12，4： | 1 |
| 10 | IFN- gamma potentiates atherosclerosis in ApoE knock-out mice显示文摘 | GUPTA S PABLO A M JIANG X | 1997 | J Clin Invest1997，99，： | 1 |
| 11 | Carbon nanofibres and activated carbon nanofibres as electrodes in supercapacitors 显示文摘 | CESAR M PABLO S EDUARDO V | 2005 | Carbon2005，43，3： | 1 |
| 12 | Effects of valsartan and amlodipine on intrarenal hemodynamics and TGF-β1 plasma levels in a crossover trial in renal transplant recipients显示文摘 | Pablo I Josep M Campistol S L | 2001 | J Am Soc Nephrol2001，12，： | 1 |
| 13 | Use of Mfu-galactoside enzymatic activity as ecotoxicological endpoint on rainbow trout red blood cells 显示文摘 | Pablos M V Boleas S Tarazona J V | 1998 | Bulletin of Environmental Contamination and Toxicology1998，61，6： | 1 |
| 14 | Aptamers: molecular tools for analytical applications显示文摘 | Teresa Mairal Veli Cengiz ?zalp Pablo Lozano Sánchez Mònica Mir Ioanis Katakis Ciara K. O’Sullivan | 2008 | Analytical and Bioanalytical Chemistry2008，，4： | 1 |
| 15 | Evaluating land administration systems: A comparative method with an application to Peru and Honduras显示文摘 | Pablo B Jose M S Cesar F | 2010 | Land Use Policy2010，27，2： | 1 |
| 16 | Nitric oxide and peroxynitrite anion modulate liver plasma membrane fluidity and Nal/K1- ATPase activity显示文摘 | Pablo M Gabricla S | 2000 | Nitric Oxide: Biology and Chemistry2000，4，4： | 1 |
| 17 | Regularized extreme learning machine for regression problems 显示文摘 | JOS M M PABLO E M EMILIO S O | 2011 | Neurocomputing2011，74，17： | 1 |
| 18 | Preparation of Sb2S3 nanostruc- tures by the ionic liquid assisted low power sonochemical method显示文摘 | Pablo S E Eduard M S | 2010 | Mater Lett2010，64，23： | 1 |
| 19 | Diagnostic efficacy and prognostic value of serum procalcitonin concentration in patients with suspected sepsis 显示文摘 | Ruiz-Alvarez M J Garcia-Valdecasas S De Pablo R | 2009 | J Intensive Care Med2009，24，1： | 1 |
| 20 | Smoking influences outcome in patients who had thrombolysed ischaemic stroke:the ENCHANTED study显示文摘Background and purpose As studies vary in defining the prognostic significance of smoking in acute ischaemic stroke(AIS),we aimed to determine the relation of smoking and key outcomes in patient participants who had thrombolysed AIS of the international quasi-factorial randomised Enhanced Control of Hypertension and Thrombolysis Stroke Study(ENCHANTED).Methods Post-hoc analyses of ENCHANTED,an international quasi-factorial randomised evaluation of intravenous alteplase-dose comparison and levels of blood pressure control in patients who had thrombolysed AIS.Multivariable logistic regression models with inverse probability of treatment weighting(IPTW)propensity scores were used to determine associations of self-reported smoking status and clinical outcomes,according to 90-day modified Rankin Scale(mRS)scores and symptomatic intracerebral haemorrhage(sICH).Results Of 4540 patients who had an AIS,there were 1008(22.2%)current smokers who were younger and predominantly male,with more comorbidities of hypertension,coronary artery disease,atrial fibrillation and diabetes mellitus,and greater baseline neurological impairment,compared with non-smokers.In univariate analysis,current smokers had a higher likelihood of a favourable shift in mRS scores(OR 0.88,95%CI 0.77 to 0.99;p=0.038)but this association reversed in a fully adjusted model with IPTW(adjusted OR 1.15,95%CI 1.04 to 1.28;p=0.009).A similar trend was also apparent for dichotomised poor outcome(mRS scores 2–6:OR 1.18,95%CI 1.05 to 1.33;p=0.007),but not with the risk of sICH across standard criteria.Conclusion Smoking predicts poor functional recovery in patients who had thrombolysed AIS.Trial registration number NCT01422616. | Lingli Sun Lili Song Jie Yang Richard I Lindley Thompson Robinson Pablo M Lavados Candice Delcourt Hisatomi Arima Bruce Ovbiagele John Chalmers Craig S Anderson Xia Wang | 2021 | Stroke & Vascular Neurology2021，6，3： | 1 |
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