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| 1 | Potential of soluble CD26 as a serum marker for colorectal cancer detection显示文摘Colorectal cancer is characterized by a low survival rate even though the basis for colon cancer development,which involves the evolution of adenomas to carcinoma,is known.Moreover,the mortality rates continue to rise in economically transitioning countries although there is the opportunity to intervene in the natural history of the adenoma–cancer sequence through risk factors,screening,and treatment.Screening in particular accounted for most of the decline in colorectal cancer mortality achieved in the USA during the period 1975-2000.Patients show a better prognosis when the neoplasm is diagnosed early.Among the variety of screening strategies,the methods range from invasive and costly procedures such as colonoscopy to more low-cost and non-invasive tests such as the fecal occult blood test(guaiac and immunochemical).As a non-invasive biological serum marker would be of great benefit because of the performance of the test,several biomarkers,including cytologic assays,DNA and mRNA,and soluble proteins,have been studied.We found that the soluble CD26(sCD26)concentration is diminished in serum of colorectal cancer patients compared to healthy donors,suggesting the potential utility of a sCD26 immunochemical detection test for early diagnosis.sCD26 originates from plasma membrane CD26 lacking its transmembrane and cytoplasmic domains.Some 90%–95%of sCD26 has been associated with serum dipeptidyl peptidase IV(DPPIV)activity.DPP-IV,assigned to the CD26 cluster,is a pleiotropic enzyme expressed mainly on epithelial cells and lymphocytes.Our studies intended to validate this test for population screening to detect colorectal cancer and advanced adenomas are reviewed here. | Oscar J Cordero Monica Imbernon Loretta De Chiara Vicenta S Martinez-Zorzano Daniel Ayude Maria Paez de la Cadena F Javier Rodriguez-Berrocal | 2011 | World Journal of Clinical Oncology2011，2，6： | 5 |
| 2 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 3 | The Nf2 tumor suppressor,merlin,functions in Rat-dependent signaling显示文摘 | Shaw R J Paez JG Curto M | 2001 | DevCell2001，1，1： | 1 |
| 4 | Non-invasive pressure support ventilation versus conventional oxygen therapy in acute cardiogenic pulmonary oedema:a randomized trial显示文摘 | Masip J Betbese AJ Paez J | | 0，，： | 1 |
| 5 | The role of categorization and in-group norms in judgments of groups and their members 显示文摘 | MARQUES J ABRAMS D PAEZ D | 1998 | Journal of Personality and Social Psychology1998，75，4： | 1 |
| 6 | EGFR mutations in lung cancercorrelation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 7 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez J G Janne P A Lee J C | | 0，，5676： | 1 |
| 8 | An integrated view of copy number and allelic alterations in the cancer genome using single nucleotide polymorphism arrays显示文摘 | Zhao X Li C Paez J G | 2004 | Cancer Res2004，64，9： | 1 |
| 9 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，304，5676： | 1 |
| 10 | Sustainable urban transportation:performance indicators and some analytical approaches显示文摘 | Black J A Paez A Suthanaya P A | 2002 | J Urban Plann Dev2002，128，4： | 1 |
| 11 | Effect of bcnzotriazolc on thc efficiency of anodizing of Al-Cu alloys 显示文摘 | PAEZ M A ZAGAL J H BUSTOS O | 1997 | Elcctrochimica Acta1997，42，23： | 1 |
| 12 | Lysine content of opaque2 maize kernels having different phenotypes 显示文摘 | Paez A V Helm J L Zuber M S | 1969 | Crop Sci1969，9，2： | 1 |
| 13 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，5676： | 1 |
| 14 | Antimicrobial therapy for Stenotro- phomonas maltophilia infection显示文摘 | Nicodemo A C Paez J I | 2007 | Eur J Chin Microbiol Infect Dis2007，26，4： | 1 |
| 15 | EGFR mutations in lung cancer: correlation with clinicalresponse to gefitinib therapy显示文摘 | PAEZ J G J: NNE P A LEE J C | 2004 | Science2004，304，5676： | 1 |
| 16 | Antiangiogenic therapy elicits malignant progression of tumors to increased local invasion and distant metastasis 显示文摘 | Paez - Ribes M Allen E Hudock J | 2009 | Cancer Cell2009，15，3： | 1 |
| 17 | Radiometric analysis of a fiber optic temperature sensor显示文摘 | J Castrellon G Paez M Strojnik | 2002 | Opt Eng2002，41，6： | 1 |
| 18 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib therapy显示文摘 | Paez JG J(a)nne PA Lee JC | 2004 | Science2004，304，： | 1 |
| 19 | EGFR mutations in lung cancer: correlation with clinical response to gefitinib therapy 显示文摘 | Paez J G Janne P A Lee J C | 2004 | Science2004，204，5676： | 1 |
| 20 | EGFR mutations in lung cancer:correlation with clinical response to gefitinib ther apy显示文摘 | PAEZ J G JANNE P A LEE J C | 2004 | Science2004，304，： | 1 |
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