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| 1 | Comparative clinical trial of S-pantoprazole versus racemic pantoprazole in the treatment of gastro-esophageal reflux disease显示文摘AIM: To compare the effi cacy and tolerability of S-pan- toprazole (20 mg once a day) versus racemic Panto- prazole (40 mg once a day) in the treatment of gastro- esophageal reflux disease (GERD). METHODS: This multi-centre, randomized, double-blind clinical trial consisted of 369 patients of either sex suf- fering from GERD. Patients were randomly assigned to receive either one tablet (20 mg) of S-pantoprazole once a day (test group) or 40 mg racemic pantoprazole once a day (reference group) for 28 d. Patients were evaluated for reduction in baseline on d 0, GERD symptom score on d 14 and 28, occurrence of any adverse effect during the course of therapy. Gastrointestinal (GI) endoscopy was performed in 54 patients enrolled at one of the study centers at baseline and on d 28. RESULTS: Signifi cant reduction in the scores (mean and median) for heart burn (P < 0.0001), acid regurgitation (P < 0.0001), bloating (P < 0.0001), nausea (P < 0.0001) and dysphagia (P < 0.001) was achieved in both groups on d 14 with further reduction on continuing the therapy till 28 d. There was a statistically signifi cant difference in the proportion of patients showing improvement in acid regurgitation and bloating on d 14 and 28 (P = 0.004 for acid regurgitation; P = 0.03 for bloating) and heart burn on d 28 (P = 0.01) between the two groups, with a higher proportion in the test group than in the refer- ence group. Absolute risk reductions for heartburn/acid regurgitation/bloating were approximately 15% on d 14 and 10% on d 28. The relative risk reductions were 26%-33% on d 14 and 15% on d 28. GI endoscopy showed no signifi cant difference in healing of esophagitis (P = 1) and gastric erosions (P = 0.27) between the two groups. None of the patients in either group reported any adverse effect during the course of therapy.CONCLUSION: In GERD, S-pantoprazole (20 mg) is more effective than racemic pantoprazole (40 mg) in improving symptoms of heartburn, acid regurgitation, bloating and equally effective in healing esophagitis and gastric erosions. The relative risk reduction is 15%-33%. Both drugs are safe and well tolerated. | Vikas G Pai Nitin V Pai Hemant P Thacker Jaisingh K Shinde Vijay P Mandora Subhash S Erram | 2006 | World Journal of Gastroenterology2006，12，37： | 19 |
| 2 | Iberian Universities: a Characterisation from ESI Ranldngs显示文摘 | Cova T F G G Pais A A C C Formosinho S O J | 2013 | Scientomet- tics2013，94，3： | 1 |
| 3 | Molecular characterization of tiny ring X chromosomes from females with functional X chromosome disomy and lack of cis X inactivation显示文摘 | JANI M M TORCHIA B S PAI G S | 1995 | Genomics1995，27，1： | 1 |
| 4 | Differential effects of cannabinoid receptor agonists on regional brain activity using pharmacological MRI显示文摘 | Chin C L Tovcimak A E Hradil V P Seifert T R Hollingsworth P R Chandran P Zhu C Z Gauvin D Pai M Wetter J Hsieh G C Honore P Frost J M Dart M J Meyer M D Yao B B Cox B F Fox G B | | 0，，02： | 1 |
| 5 | Mass mortality of Penae- us monodon larvae due to antibiotic -resistant Vibrio harveyi infection 显示文摘 | KARUNASAGAR I PAI R MALATHI G R | 1994 | Aquaculture1994，128，34： | 1 |
| 6 | Structural basis for aminoglycoside inhibition of bacterial ribosome recycling 显示文摘 | Borovinskaya MA Pai RD Zhang W Schuwirth BS Holton JM Hirokawa G Kaji H Kaji A Cate JH | 2007 | Nat Struct Mol Biol2007，14，8： | 1 |
| 7 | Mass mortality of Penaeus monodon larvae due to antibiotic-resistant Vibrio harveyi infection 显示文摘 | Karunasagar I Pai R Malathi G R | 1994 | Aquaculture1994，128，： | 1 |
| 8 | Meta-analysis:new tests for the diagnosis of latent tuberculosis infection:areas of uncertainty and recommendations for research显示文摘 | Menzies D Pai M Comstock G | 2007 | Ann Intern Med2007，146，5： | 1 |
| 9 | Molecular characterization oftiny ring X chromosomes from females with functional X chromosome di-somy and lack of cis X inactivation显示文摘 | Jani M M Torchia B S Pai G S | 1995 | Genomics1995，27，1： | 1 |
| 10 | J Catal显示文摘 | Kumar S B Mirajkar S P Pais G C G Kumar P Kumar R | 1995 | 156:1631995，156，： | 1 |
| 11 | Experimental study of loosening of threaded fasteners due to dynamic shear loads显示文摘 | Pai N G Hess D P | 2002 | Journal of Sound and Vibration2002，253，3： | 1 |
| 12 | Computer extended series solution for unsteady flow in a contracting or expanding pipe 显示文摘 | Bujurke N M Pai N P Jayaraman G | 1998 | IMA Journal of Applied Mathematics1998，60，2： | 1 |
| 13 | AFLP-based genetic linkage map for the red flour beetle (Tribolium castaneum)显示文摘 | ZHONG D PAI A YAN G | 2004 | Journal of Heredity2004，95，1： | 1 |
| 14 | Microbial degradation of mefenoxam in rhizosphere of Zinnia angastifolia显示文摘 | PAI G S RILEY M B CAMPER N D | 2001 | Chemosphere2001，44，： | 1 |
| 15 | In-vitro/in-vivo characterization of trans- resveratrol-loaded nanoparticulate drug delivery system for oral administration 显示文摘 | SINGH G PAI R S | 2014 | J Pharm Pharmac2014，66，8： | 1 |
| 16 | Iron-magnesium hydroxycarbonate (fermegate) : a novel non-calcium-containing phosphate binder for the treatment of hyper-phosphatemia in chronic hemodialysis patients 显示文摘 | Mclntyre C W Pai P Warwick G | 2009 | Clin J Am Soc Nephrol2009，4，2： | 1 |
| 17 | Phenoxybenzamine treatment can lead to loss of endothelial cell viability显示文摘 | Pai K R Conant A R Browning P G | | 0，，05： | 1 |
| 18 | Meta-analysis:new tests for the diagnosis of latent tuberculosis infection:areas of uncertainty and recommendations for research显示文摘 | Menzies D Pai M Comstock G | 2007 | Ann Intern Med2007，146，5： | 1 |
| 19 | 显示文摘 | Pai P G Chao S S Takagi Y | 1986 | J Vac Sci Technol A1986，4，： | 1 |
| 20 | Voltage collapse analysis with reactive generation and voltage dependent load constraints显示文摘 | Pai M A O'Grady M G | 1989 | Electric Machines Power System1989，17，： | 1 |
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