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| 1 | Vascular-confined multi-passage discoidal nanoconstructs for the low-dose docetaxel inhibition of triple-negative breast cancer growth显示文摘Taxane efficacy in triple negative breast cancer(TNBC)is limited by insufficient tumor accumulation and severe off-target effects.Nanomedicines offer a unique opportunity to enhance the anti-cancer potency of this drug.Here,1,000 nm×400 nm discoidal polymeric nanoconstructs(DPN)encapsulating docetaxel(DTXL)and the near infrared compound Iipid-Cy5 were engineered.DPN were obtained by filling multiple times cylindrical wells in a poly(vinyl alcohol)template with a polymer mixture comprising poly(lactic-co-glycolic acid)(PLGA)and poly(ethylene glycol)diacrylate(PEG-DA)chains together with therapeutic and imaging agents.The resulting“multi-passage”DPN exhibited higher DTXL loading,Iipid-Cy5 stability,and stiffness as compared to the conventional'single-passage'approach.Confocal microscopy confirmed that DTXL-DPN were not taken up by MDA-MB-231 cells but would rather sit next to the cell membrane and slowly release DTXL thereof.Empty DPN had no toxicity on TNBC cells,whereas DTXL-DPN presented a cytotoxic potential comparable to free DTXL(IC_(50)=2.6 nM±1.0 nM vs.7.0 nM±1.09 nM at 72 h).In orthotopic murine models,DPN accumulated in TNBC more efficiently than free-DTXL.With only 2 mg/kg DTXL,intravenously administered every 2 days for a total of 13 treatments,DTXL-DPN induced tumor regression and were associated to an overall 80%survival rate as opposed to a 30%survival rate for free-DTXL,at 120 days.All untreated mice succumbed before 90 days.Collectively,this data demonstrates that vascular confined multi-passage DPN,biomimicking the behavior of circulating platelets,can efficiently deliver chemotherapeutic molecules to malignant tissues and effectively treat orthotopic TNBC at minimal taxane doses. | Alessia Felici Daniele Di Mascolo Miguel Ferreira Simone Lauciello Luca Bono Andrea Armirotti Arunkumar Pitchaimani Anna Lisa Palange Paolo Decuzzi | 2022 | Nano Research2022，15，1： | 2 |
| 2 | Electromagnetic chirality induced by graphene inclusions in multilayered metamaterials显示文摘We theoretically investigate the electromagnetic response of a novel class of multilayered metamaterials obtained by alternating graphene sheets and dielectric layers,the whole structure not exhibiting a plane of reflection symmetry along the stacking direction.We show that the electromagnetic response of the structure is characterized by a magneto-electric coupling described by an effective chiral parameter.Exploiting the intrinsic tunability of graphene–light coupling,we prove that one can tune both the dielectric and the chiral electromagnetic response by varying the graphene chemical potential through external voltage gating. | Carlo Rizza Elia Palange Alessandro Ciattoni | 2014 | Photonics Research2014，2，5： | 2 |
| 3 | COPD:a multifactorial systemic disease显示文摘 | Huertas A Palange P | 2011 | Ther Adv Respir Dis2011，5，3： | 1 |
| 4 | Holistic aspects in landscape development: a sce- nario approach显示文摘 | Hannes Palang | 2000 | Landscape and Urban Planning2000，，50： | 1 |
| 5 | Circulating haemopoietic and endothelial progenitor cells are decreased in COPD显示文摘 | Palange P Testa U Huertas A | 2006 | Eur Respir J2006，27，3： | 1 |
| 6 | Effect of redeced body weight on muscle aerobic capacity in patients with COPD显示文摘 | Palange P Forte S Onorati V | 1998 | Chest1998，114，1： | 1 |
| 7 | Intrarenal hemo- dynamic and oxidative stress in patients with obstructive sleep apnea syndrome显示文摘 | SARDO L PALANGE P DI MARIO F | 2015 | Sleep Breath2015，19，4： | 1 |
| 8 | Trauma hemorrhagic shock-induced lung injury involves agut-lymph-induced TLR4 pathway in mice显示文摘 | REINODC PISARENKO V PALANGE D | 2011 | PLoS One2011，6，8： | 1 |
| 9 | Trauma hemorrhagic shock - induced lung injury involves a gut - lymph - induced TLR4 pathway in mice显示文摘 | Reino DC Pisarenko V Palange D | 2011 | PLoS One2011，6，14： | 1 |
| 10 | Recommendations on the use of exercise testing in clinical practice显示文摘 | Palange P Ward SA Carlsen KH | 2007 | Eur Respir J2007，29，1： | 1 |
| 11 | COPD:a multifactorial systemic disease显示文摘 | Huertas A Palange P | 2011 | Ther Adv Respir Dis2011，5，3： | 1 |
| 12 | Landscapes in change-opposing attitudes in Saaremaa, Estonia 显示文摘 | Egle Kaur Haanes Palang Helen Soovali | 2004 | Landscape and Urban Planning2004，67，14： | 1 |
| 13 | Activation of toll -like receptor 4 is necessary for trauma hemorrhagic shock - induced gut injury and polymorphonuclear neutrophil priming 显示文摘 | Reino DC Palange D Feketeova E | 2012 | Shock2012，38，1： | 1 |
| 14 | Digging in the past: Newconceptual models in landscape history and their relevance in peri-urbanlandscapes显示文摘 | PALANG H SPEK T STENSEKE M | 2011 | Landscape and Urban Planning2011，100，： | 1 |
| 15 | Water and sodium imbalance in COPD patients显示文摘 | Valli G Fedeli A Palange P | 2004 | Monaldi Arch Chest Dis2004，61，2： | 1 |
| 16 | Holistic aspects in landscape development:a scenario approach显示文摘 | Hannes palang etc | 2000 | Landscape and Urban Planning2000，，50： | 1 |
| 17 | Rural Landscapes: past processes and furore strategies显示文摘 | Hannes Palang | 2005 | Landscape and Urban Planning2005，70，： | 1 |
| 18 | Role of charge saturation in photorefractive dynamics of micron-sized beams and departure from soliton behavior显示文摘 | CIATTONI A PALANGE E | 2006 | Phys Rev E2006，73，01： | 1 |
| 19 | Cardiopulm onary exercise testing in the evaluation of patients with ventilatory vs circulatory causes of re duced exercise tolerance显示文摘 | Palange P Carlone S Forres | 1994 | Chest1994，105，： | 1 |
| 20 | Onset of action of formoterol versus salmeterol via dry powder inhalers in moderate chronic obstructive pulmonary disease:a randomized,placebo-controlled,double-blind,crossover study显示文摘 | Cazzola M Paggiaro P Palange P | 2012 | Clin Drug Investig2012，32，3： | 1 |
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