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| 1 | 认知行为疗法与佐匹克隆治疗老年慢性原发性失眠患者的比较:一项随机对照试验显示文摘Context: Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested beneficial outcomes of both psychological and pharmacological treatments, but blinded placebo-controlled trials comparing the effects of these treatments are lacking. Objective: To examine short-and long-term clinical efficacy of cognitive behavioral therapy (CBT) and pharmacological treatment in older adults experiencing chronic primary insomnia. Design, Setting, and Participants: A randomized, double-blinded, placebo-controlled trial of 46 adults (mean age, 60.8 y; 22 women) with chronic primary insomnia conducted between January 2004 and December 2005 in a single Norwegian university-based outpatient clinic for adults and elderly patients. Intervention: CBT (sleep hygiene, sleep restriction, stimulus control, cognitive therapy, and relaxation; n=18), sleep medication (7.5-mg zopiclone each night; n=16), or placebo medication (n=12). All treatment duration was 6 weeks, and the 2 active treatments were followed up at 6 months. Main Outcome Measures: Ambulant clinical polysomnographic data and sleep diaries were used to determine total wake time, total sleep time, sleep efficiency, and slow-wave sleep (only assessed using polysomnography) on all 3 assessment points. Results: CBT resulted in improved short-and long-term outcomes compared with zopiclone on 3 out of 4 outcome measures. For most outcomes, zopiclone did not differ from placebo. Participants receiving CBT improved their sleep efficiency from 81.4%at pretreatment to 90.1%at 6-month follow-up compared with a decrease from 82.3%to 81.9%in the zopiclone group. Participants in the CBT group spent much more time in slow-wave sleep (stages 3 and 4) compared with those in other groups, and spent less time awake during the night. Total sleep time was similar in all 3 groups; at 6 months, patients receiving CBT had better sleep efficiency using polysomnography than those taking zopiclone. Conclusion: These results suggest that interventions based on CBT are superior to zopiclone treatment both in short-and long-term management of insomnia in older adults. | Sivertsen B Omvik S Pallesen S. 谢琰臣 | 2006 | 世界核心医学期刊文摘(神经病学分册)2006，2，11： | 3 |
| 2 | Bright light treatment has limited effect in subjects over 55 years with mild early morning awakening显示文摘 | Pallesen S Nordhus IH Skelton SH | 2005 | Percept Mot Skills2005，101，3： | 1 |
| 3 | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial 显示文摘 | Sivertsen B Omvik S Pallesen S | 2006 | JAMA2006，295，24： | 1 |
| 4 | Clinical performance of a hybrid resin composite with and without an intermediate layer of flowable resin composite: a 7-year evaluation显示文摘 | van Dijken JW Pallesen U | 2011 | Dent Mater2011，27，2： | 1 |
| 5 | A 10-year trend of insomnia prevalence in the adult Norwegian population 显示文摘 | Pallesen S Sivertsen B Nordhus IH | 2014 | Sleep Med2014，15，2： | 1 |
| 6 | Inhibitory effects of human and bovine milk constituents on rotavirus infections显示文摘 | Kvistgaard AS Pallesen LT Arias CF | 2004 | J Dairy Sei2004，87，12： | 1 |
| 7 | Does loneliness mediate the stress-sleep quality relation? The Hordaland Health Study 显示文摘 | Aanes MM Hetland J Pallesen S | 2011 | Int Psychogeriatr2011，23，6： | 1 |
| 8 | Isolation and characterization of MUC15,a novel cell membrane-associated mucin显示文摘 | PALLESEN L T BERGLUND L RASMUSSEN L K | 2002 | Eur J Biochem2002，269，： | 1 |
| 9 | The association of Epstein- Barr virus (EBV)with T - cell lymphoproliferations and Hodgkin's disease: two new developments in the EBV field显示文摘 | Pallesen G Hamilton - Dutoit SJ Zhou XG | 1993 | Adv Cancer Res1993，62，： | 1 |
| 10 | Respiration and ethylene production by kiwifruit following hot water dips显示文摘 | Irving DE Pallesen JC Cheah LH | 1991 | Postharvest Biology and Technology1991，1，： | 1 |
| 11 | Long-term dentin retention of etch- and-rinse and self-etch adhesives and a resin-modified glass ionomer cement in non-carious cervical lesions显示文摘 | van Dijken JW Pallesen U | 2008 | Dent Mater2008，24，7： | 1 |
| 12 | Respiration and ethylene Production in kiwifruit following hot water dips显示文摘 | IRVING D E PALLESEN J C CHEAH L H | 1991 | Postharvest Biology Technology1991，1，： | 1 |
| 13 | Prevalence and risk factors of subjective sleepiness in general adult population显示文摘 | Pallesen S Nordhus IH Omvik S etal | 2007 | Sleep2007，30，5： | 1 |
| 14 | Authentic display of a cholera toxin epitopeby chimeric type 1 fimbriae:effects of insert positions and host background显示文摘 | STENTEBJERG-OLESEN B PALLESEN L JENSEN L B | | Microbiology0，143，： | 1 |
| 15 | Tooth bleaching--a critical review of the biological aspects显示文摘 | Dahl JE Pallesen U | 2003 | Crit Rev Oral Biol Med2003，14，4： | 1 |
| 16 | The impact of partial sleep depriva- tion on military naval officers' ability to anticipate moral and tactical problems in a simulated maritime combat operation 显示文摘 | Olsen O K Pallesen S Espevlk R | 2013 | Internayional Maritime Health2013，64，2： | 1 |
| 17 | A randomized controlled three year evaluation of 'bulk-filled' posterior resin restorations based on stress decreasing resin technology显示文摘 | van Dijken JW Pallesen U | 2014 | Dent Mater2014，30，9： | 1 |
| 18 | Sortilin and SorLA regulate neuronal sorting of trophic and dementia-linked proteins 显示文摘 | Pallesen LT Vaegter CB | 2012 | Mol Neurohiol2012，45，2： | 1 |
| 19 | Prevalence and correlates of insomnia and excessive sleepiness in adults with obstruetive sleep apnea symptom s显示文摘 | Bjorvatn B Pallesen S Gronli J | 2014 | Percept Mot Skills2014，118，2： | 1 |
| 20 | Chimeric FimH adhesin of type 1 fimbriae:a bacterial display system for heterologous sequences显示文摘 | PALLESEN L POULSEN L K CHRISTIANSEN G | | Microbiology0，141，： | 1 |
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