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| 1 | New therapeutic opportunities for Hepatitis C based on small RNA显示文摘Hepatitis C virus (HCV) infection is one of the major causes of chronic liver disease, including cirrhosis and liver cancer and is therefore, the most common indication for liver transplantation. Conventional antiviral drugs such as pegylated interferon-alpha, taken in combination with ribavirin, represent a milestone in the therapy of this disease. However, due to different viral and host factors, clinical success can be achieved only in approximately half of patients, making urgent the requirement of exploiting alternative approaches for HCV therapy. Fortunately, recent advances in the understanding of HCV viral replication and host cell interactions have opened new possibilities for therapeutic intervention. The most recent technologies, such as small interference RNA mediated gene-silencing, anti-sense oligonucleotides (ASO), or viral vector based gene delivery systems, have paved the way to develop novel therapeutic modalities for HCV. In this review, we outline the application of these technologies in the context of HCV therapy. In particular, we will focus on the newly defined role of cellular microRNA (miR-122) in viral replication and discuss its potential for HCV molecular therapy. | Qiu-wei Pan Scot D Henry Bob J Scholte Hugo W Tilanus Harry LA Janssen Luc JW van der Laan | 2007 | World Journal of Gastroenterology2007，13，33： | 4 |
| 2 | Acupuncture at Xinshe point for 30 cases of in-tractable Hiccups 显示文摘 | Xing JW Pan CM | 2013 | Chinese Acupuncture & Moxibustion2013，33，4： | 1 |
| 3 | Efficacy of acarbose in Chiness subjects with impaired glucose tolerance 显示文摘 | Pan CY Gao Y Chen JW | 2003 | Diabets Resclin Pract2003，61，3： | 1 |
| 4 | Improvement in timing of antibiotic ration by using a prophylactic antibiotic record form显示文摘 | Pan SC Sun HY Lin JW | 2008 | J Formos Med Assoc2008，107，3： | 1 |
| 5 | Prenatal diagnosis of fetal lymphocytes in the maternal blood显示文摘 | Graf D Pan JW | 1972 | Obstet Gynecol1972，40，： | 1 |
| 6 | Improvement in timing of antibiotic administration by using a prophylactic antibiotic record form显示文摘 | Pan SC Sun HY Lin JW | 2008 | J Formos Med Assoc2008，107，3： | 1 |
| 7 | Ultra-early surgery for poor-grade intracranial aneurysmal subarachnoid hemorrhage:a preliminary study显示文摘 | Pan JW Zhan RY Wen L | 2009 | Yonsei Med J2009，50，4： | 1 |
| 8 | Cationic Lipid-coated magnet-ic nanoparticles associated with transferrin for gene delivery 显示文摘 | PAN X GUAN J YOO JW | 2008 | Int J Pharm2008，358，1： | 1 |
| 9 | Aluminum-induced cell death in root-tip cells of barley显示文摘 | Pan JW Zhu MY Chen H | 2001 | Environmental and Experimental Botany2001，，46： | 1 |
| 10 | Management of cellular energy by the AMP-activated protein kinase system 显示文摘 | Hardie DG Seutt JW Pan DA | 2003 | FEBS Lett2003，546，1： | 1 |
| 11 | Ultra-early surgery for poor-gradeintracranial aneurismal subarachnoid hemorrhage: a preliminary study显示文摘 | Pan JW Zhan RY Wen L | 2009 | Yonsei Med J2009，50，4： | 1 |
| 12 | Long-term high salt diet causes hypertension and alters renal cytokine gene expression profiles in Sprague-Dawley rats显示文摘 | Gu JW Young E Pan Z J etal | 2009 | Bejing Da Xue Xue Bao2009，41，5： | 1 |
| 13 | Management of cellular energy by the AMP-activated protein kinase system显示文摘 | Hardie DG Scott JW Pan DA | | 0，，1： | 1 |
| 14 | Individual overexpression of five subunits of human translation initiation factor elF3 promotes malignant transformation of immortal fibroblast cells显示文摘 | Zhang L Pan X Hershey JW | 2007 | J Biol Chem2007，282，8： | 1 |
| 15 | Regional cerebral blood flow and magnetic resonance spectroscopic imaging findings in diaschi- sis from stroke显示文摘 | Chu WJ Mason GF Pan JW | 2002 | Stroke2002，33，5： | 1 |
| 16 | Regional energetic dysfunction in hippocampal epilepsy 显示文摘 | Pan JW Kim JH Cohen-Gadol A | 2005 | Acta neurologica Scandinavica2005，111，4： | 1 |
| 17 | Ultra-early surgery for poor-grade intracranial aneurysmal subarachnoid hemorrhage: a preliminary study 显示文摘 | Pan JW Zhan RY Wen L | 2009 | Yonsei Med J2009，50，： | 1 |
| 18 | Neurometabolism in human epilepsy显示文摘 | Pan JW Williamson A Cavus I | 2008 | Epilepsia2008，49，： | 1 |
| 19 | Improvement in timing of antibiotic administeration by using aprophylactic antibiotic record form显示文摘 | Pan SC Sun HY Lin JW | 2008 | J Formos Med Assoc2008，107，3： | 1 |
| 20 | Decreased hippocampal volume on MRI is associated with increased extracellular glutamate in epilepsy patients显示文摘 | Cavus I Pan JW Hetherinqton HP | | 0，，08： | 1 |
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