|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Antibiotic Treatment Drives the Diversification of the Human Gut Resistome显示文摘Despite the documented antibiotic-induced disruption of the gut microbiota, the impact of antibiotic intake on strain-level dynamics, evolution of resistance genes, and factors influencing resistance dissemination potential remains poorly understood. To address this gap we analyzed public metagenomic datasets from 24 antibiotic treated subjects and controls, combined with an in-depth prospective functional study with two subjects investigating the bacterial community dynamics based on cultivation-dependent and independent methods. We observed that shortterm antibiotic treatment shifted and diversified the resistome composition, increased the average copy number of antibiotic resistance genes, and altered the dominant strain genotypes in an individual-specific manner. More than 30% of the resistance genes underwent strong differentiation at the single nucleotide level during antibiotic treatment. We found that the increased potential for horizontal gene transfer, due to antibiotic administration, was ~3-fold stronger in the differentiated resistance genes than the non-differentiated ones. This study highlights how antibiotic treatment has individualized impacts on the resistome and strain level composition, and drives the adaptive evolution of the gut microbiota. | Jun Li Elizabeth A.Rettedal Eric van der Helm Mostafa Ellabaan Gianni Panagiotou Morten O.A.Sommer | 2019 | Genomics, Proteomics & Bioinformatics2019，17，1： | 4 |
| 2 | Effect of osmotic agents on osmotic dehydration of fruits显示文摘 | PANAGIOTOU N M KARATHANOS V T MAROULIS Z | 1999 | Drying Technology1999，17，12： | 1 |
| 3 | Nonlinear cyclic truss model for reinforced concrete walls 显示文摘 | Panagiotou M Restrepo J I Schoettler M | 2012 | Structural Journal2012，109，2： | 1 |
| 4 | Effect of EAA and tarch on the Thermooxidative Degradation of LDPE 显示文摘 | Bikiaris D Prinos J Panagiotou C | 1997 | Polym Degra Stab1997，56，： | 1 |
| 5 | Three-dimensional cyclic beam-truss model for non-planar reinforced concrete walls 显示文摘 | Lu Y Panagiotou M | 2014 | Journal of Structural Engineering2014，140，04： | 1 |
| 6 | The use of time to ignition data for characterizing the thermal inertia and the minimum (critical) heat flux for ignition or pyrolysis 显示文摘 | DELICHATSIOS M A PANAGIOTOU T H KILEY F | 1991 | Combustion and Flame1991，84，： | 1 |
| 7 | Seismic Response of 20-story Base-isolated and Fixed-base Reinforced Concrete Structural Wall Buildings at a Near-fault Site 显示文摘 | Calugaru V Panagiotou M | 2014 | Earthquake Engineering & Structural Dynamics2014，43，92： | 1 |
| 8 | Effect of compounds released during pretreatment of wheat straw on microbial growth and enzymatic hydrolysis rates 显示文摘 | Panagiotou G Olsson L | 2007 | Biotechnology and Bioengineering2007，96，2： | 1 |
| 9 | LDPE/Starch Blends Compatibilized with PE-g-MA Copolymers 显示文摘 | Bidiaris D Panagiotou C | 1998 | J Appl Polym Sci1998，70，： | 1 |
| 10 | Purification and characterisation of NAD^+ -dependent xylitol dehydrogenase from fusarium oxysporium显示文摘 | Panagiotou G Kekos D | 2002 | Biotechnology Letters2002，24，： | 1 |
| 11 | A Survival Analysis of Patients with Malignant Biliary Strictures Treated by Percutaneous Metallic Stenting显示文摘 | Elias N. Brountzos Nikolaos Ptochis Irene Panagiotou Katerina Malagari Chara Tzavara Dimitrios Kelekis | 2007 | CardioVascular and Interventional Radiology2007，，1： | 1 |
| 12 | FNI2~ and irisin in humans: I ~ Predictors of circulating concentrations in serum and plasma and ll, mRNA expression and circulating concentrations in response to weight loss and exercise 显示文摘 | HUH J Y PANAGIOTOU G MOUGIOS V | 2012 | Metabolism2012，61，12： | 1 |
| 13 | Zeolite Sorbent that Effectively Removes Mercury From Flue Gases 显示文摘 | Morency Panagiotou T Senior C L | 2002 | Filtrat2002，，39： | 1 |
| 14 | Measurements of particle flame temperature using three - color optical pyrometry 显示文摘 | Panagiotou T Levendis Y A | 1996 | Combustion and Flame1996，104，3： | 1 |
| 15 | Circulating irisin,omentin-1,and lipoprotein subparticles in adults at higher cardiovascular risk显示文摘 | Panagiotou G Mu L Na B | 2014 | Metabolism2014，63，10： | 1 |
| 16 | Measurements of particle flame temperature using three-color optical pyrometry 显示文摘 | Panagiotou T Levendis Y A | 1996 | Combustion and Flame1996，104，27： | 1 |
| 17 | Managerial cognition of competitive environ- ments: a strategic group analysis 显示文摘 | Panagiotou G | 2006 | Management Research News2006，29，7： | 1 |
| 18 | Moisture diffusivity:Literature data compilation for foodstuffs显示文摘 | Panagiotou N M Krokida M K Maroulis Z B | 2004 | International Journal of Food Properties2004，7，2： | 1 |
| 19 | The'telescopic observa- tions'framework:an attainable strategic tool显示文摘 | PANAGIOTOU G WIJNEN R | 2005 | Marketing Intelligence& Planning2005，23，2： | 1 |
| 20 | Effect of compounds released during pretreatment of wheat straw on microbial growth and enzymatic hydrolysis rates显示文摘 | Panagiotou G Olsson L | 2007 | Biotechnology and Bioengineering2007，96，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员