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| 1 | Nuclear imaging in detection and monitoring of cardiotoxicity显示文摘Cardiotoxicity as a result of cancer treatment is a novel and serious public health issue that has a significant impact on a cancer patient’s management and outcome.The coexistence of cancer and cardiac disease in the same patient is more common because of aging population and improvements in the efficacy of antitumor agents.Left ventricular dysfunction is the most typical manifestation and can lead to heart failure.Left ventricular ejection fraction measurement by echocardiography and multigated radionuclide angiography is the most common diagnostic approach to detect cardiac damage,but it identifies a late manifestation of myocardial injury.Early non-invasive imaging techniques are needed for the diagnosis and monitoringof cardiotoxic effects.Although echocardiography and cardiac magnetic resonance are the most commonly used imaging techniques for cardiotoxicity assessment,greater attention is focused on new nuclear cardiologic techniques,which can identify high-risk patients in the early stage and visualize the pathophysiologic process at the tissue level before clinical manifestation.The aim of this review is to summarize the role of nuclear imaging techniques in the non-invasive detection of myocardial damage related to antineoplastic therapy at the reversible stage,focusing on the current role and future perspectives of nuclear imaging techniques and molecular radiotracers in detection and monitoring of cardiotoxicity. | Carmen D’Amore Paola Gargiulo Stefania Paolillo Angela Maria Pellegrino Tiziana Formisano Antonio Mariniello Giuseppe DellaRatta Elisabetta Iardino Marianna D’Amato Lucia La Mura Irma Fabiani Flavia Fusco Pasquale Perrone Filardi | 2014 | World Journal of Radiology2014，6，7： | 2 |
| 2 | Compromised nutritional status in patients with end-stage liver disease:Role of gut microbiota显示文摘Background: Patients with end-stage liver disease(ESLD) have a compromised nutritional status because of the liver crucial role in regulating metabolic homeostasis and energy balance.Data sources: A systematic review of literature based on extensive relevant articles published from 2001 to 2017 in English in Pub Med database was performed by searching keywords such as liver disease, nonalcoholic liver disease, alcoholic liver disease, malnutrition, epigenetics, gut microbiota, and probiotics.Results: Liver transplantation would be one eligible therapy for ESLD patients, even if, the clinical outcome is negatively influenced by malnutrition and/or infections. The malnutrition is a condition of nutrient imbalance with a high incidence in ESLD patients. An accurate evaluation of nutritional status could be fundamental for reducing complications and prolonging the survival of ESLD patients including those undergoing liver transplantation. In addition, the interaction among nutrients, diet and genes via epigenetics has emerged as a potential target to reduce the morbidity and mortality in ESLD patients. The malnutrition induces changes in gut microbiota causing dysbiosis with a probable translocation of bacteria and/or pathogen-derived factors from the intestine to the liver. Gut microbiota contribute to the progression of chronic liver diseases as well as hepatocellular carcinoma. The administration of probiotics modulating gut microbiota could improve all chronic liver diseases.Conclusions: This review provides an update on malnutrition status linked to epigenetics and the potential benefit of some probiotics on the management of ESLD patients. In support of this view and to reveal the constant and growing interest in this field, some clinical trials are reported. | Maria Vasco Rossella Paolillo Concetta Schiano Linda Sommese Oreste Cuomo Claudio Napoli | 2018 | Hepatobiliary & Pancreatic Diseases International2018，17，4： | 2 |
| 3 | Inhibition of t cardiac phosphatidylethanolamine N - methylation by oxygen free radicals 显示文摘 | Kaneko M Panagia V Paolillo G | 1990 | Biochim Biophys Acta1990，1021，1： | 1 |
| 4 | IFFTC-Based Procedure for Hidden Tone Detection 显示文摘 | LIGUORI Consolatina PAOLILLO Alfredo | 2007 | IEEE Transac- tions on Instrumentation and Measurement2007，56，1： | 1 |
| 5 | Immuno modulatory effects of Laetobaeillus plantarum on hu- man colon cancer cells 显示文摘 | Paolillo R Romano C C Sorrentino S | 2009 | Int Immunopharmaeol2009，9，11： | 1 |
| 6 | Induction of VEGF and MMP-9 expression by toll-like receptor 2/4 in human endothelial cells infected with Chlamydia pneumonia 显示文摘 | Paolillo R Lovene MR Romano Carratelli C | 2012 | Int J Immunopathol Pharmacol2012，25，2： | 1 |
| 7 | Electri- cal Stimulation of Schwann Ceils Promotes Sustained In- creases in Neurite Outgrowth显示文摘 | Koppes AN Nordberg AL Paolillo GM | 2014 | Tissue Eng Part A2014，20，34： | 1 |
| 8 | cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons显示文摘 | Zanassi P Paolillo M Feliciello A Avvedimento EV Gallo V Schinelli S | 2001 | J Biol Chem2001，275，11： | 1 |
| 9 | Induction of VEGF and MMP-9 expression by Toll-like receptor 2/4 in human endothelial cells infected with Chlamydia pneumoniae 显示文摘 | Paolillo R Iovene MR Romano Carratelli C | 2012 | Int J Immunopathol Pharmacol2012，25，2： | 1 |
| 10 | Pulmonary embolism due to compression of the inferior vena cava by a hepatic hemangioma显示文摘 | Paolillo V Sicuro M Nejrotti A Rizzetto M Casaccia M | 1993 | Tex Heart Inst J1993，20，： | 1 |
| 11 | The relationship between inflammation and atrophy in clinically isolated syndromes suggestive of multiple sclerosis显示文摘 | Paolillo A Piattella MC Pantano P | 2004 | J Neurol2004，251，： | 1 |
| 12 | RbAp48 is atarget of nuclear factor-kappaB activity in thyroid cancer 显示文摘 | Pacifico F Paolillo M Chiappetta G | 2007 | J Clin Endocrinol Metab2007，92，4： | 1 |
| 13 | N - terminal pro - b - type natriuretic peptide and left atrial function in patients with congestive heart failure and severely reduced ejection fraction显示文摘 | Prastaro M Paolillo S Savarese G | 2011 | Eur J Echo- cardiogr2011，12，7： | 1 |
| 14 | A Taxonomy of Organizational Impression Management Taeties 显示文摘 | Mohamed AA Gardner W L Paolillo J P | 1999 | Ad- vances in Competitiveness Review1999，，7： | 1 |
| 15 | Comparison of methods for the determination of ochratoxin A in wine 显示文摘 | Leitner L Zollner P Paolillo A | 2002 | Analytiea Chimica Acta2002，453，： | 1 |
| 16 | cAMP-dependent protein kinase induces cAMP-response element-binding protein phosphorylation via an intracellular calcium release/ERK-dependent pathway in striatal neurons 显示文摘 | Zanassi P Paolillo M FelicieUo A | 2001 | Biol Chem2001，276，11： | 1 |
| 17 | Crack resistance in chery tomato fruit correlates with cuticular memberane thickness显示文摘 | Matas A J Cobb E D Paolillo D J | 2004 | HortScience2004，39，6： | 1 |
| 18 | Standard uncertainty evaluation in image-based meas- urements 显示文摘 | DE SANTO M LIGUORI C PAOLILLO A | 2004 | Measurement: Journal of the Interna- tional Measurement Confederation2004，36，34： | 1 |
| 19 | Assessment of cardiac sympathetic activity by MIBG imaging in patients with heart failure: a clinical appraisal显示文摘 | Perrone-Filardi P Paolillo S Dellegrottaglie S | 2011 | Heart2011，97，22： | 1 |
| 20 | Comparison of methods for the determination of Ochratoxin A in wine显示文摘 | Leitner A Z?llner P Paolillo A Stroka J Papadopoulou-Bouraoui A Jaborek S Anklam E Lindner W | 2002 | Analytica Chimica Acta2002，453，1： | 1 |
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