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| 1 | Liver insulin-like growth factor 2 methylation in hepatitis C virus cirrhosis and further occurrence of hepatocellular carcinoma显示文摘AIM: To assess the predictive value of the insulinlike growth factor 2 (Igf2) methylation profile for the occurrence of Hepatocellular Carcinoma (HCC) in hepatitis C (HCV) cirrhosis. METHODS: Patients with: (1) biopsy-proven compensated HCV cirrhosis; (2) available baseline frozen liver sample; (3) absence of detectable HCC; (4) regular screening for HCC; (5) informed consent for genetic analysis were studied. After DNA extraction from liver samples and bisulfite treatment, unbiased PCR and DHPLC analysis were performed for methylation analysis at the Igf2 locus. The predictive value of the Igf2 methylation profile for HCC wasassessed by Kaplan-Meier and Cox methods. RESULTS: Among 94 included patients, 20 developed an HCC during follow-up (6.9 ± 3.2 years). The methylation profile was hypomethylated, intermediate and hypermethylated in 13, 64 and 17 cases, respectively. In univariate analysis, two baseline parameters were associated with the occurrence of HCC: age (P = 0.01) and prothrombin (P = 0.04). The test of linear tendency between the three ordered levels of Igf2 methylation and probability of HCC occurrence was significant (Log Rank, P = 0.043; Breslow, P = 0.037; Tarone-Ware, P = 0.039). CONCLUSION: These results suggest that hypomethylation at the Igf2 locus in the liver could be predictive for HCC occurrence in HCV cirrhosis. | Philippe Couvert Alain Carrié Jacques Pariès Jenny Vaysse Audrey Miroglio Antoine Kerjean Pierre Nahon Jamel Chelly Jean-Claude Trinchet Michel Beaugrand Nathalie Ganne-Carrié | 2008 | World Journal of Gastroenterology2008，14，35： | 6 |
| 2 | Origin of pit chains in the floor of lunar Copernican craters显示文摘There are small pit chains in the floor of lunar Copernican craters. They are usually so small in scale that there are few lunar spacecrafts to detect their detailed morphology. Combining camera data from Lunar Orbiter, Lunar Reconnaissance Orbiter (LRO), Kaguya and Chang’e-1 missions, 5 representative large Copernican craters on various terrains of the lunar surface are chosen to study the origin of the pit chains in the crater floor. The morphology and distribution characteristic of the pit chains are referred by the high resolution images in this research. It is suggested that it is the magma activities from the subsurface magma layer combining with the existence of fractures and faults under the crater floor that leaded the formation of the pit chains. The model is further verified and discussed using the regolith thickness data in the crater floor. Our model suggests that the pit chains are still developing in the floor of the Copernican craters and the Moon may not be totally cold. Finally, the model limitation and potential future work are discussed based on available data. | XIAO ZhiYong 1* , ZENG ZuoXun 1,2 , XIAO Long 1,2 , FA WenZhe 3 & HUANG Qian 3,4 1 Faculty of Earth Sciences, China University of Geosciences, Wuhan 430074, China 2 Research Center for Space Science and Technology, China University of Geosciences, Wuhan 430074, China 3 Institut de Physique du Globe de Paris, 4 Avenue de Neptune, Saint Maur des Fosse’s, 94100, France 4 Shanghai Astronomical Observatory, Chinese Academy of Sciences, Shanghai 200030, China | 2010 | Science China(Physics,Mechanics & Astronomy)2010，53，12： | 4 |
| 3 | Risk-adjustment in hepatobiliarypancreatic surgery显示文摘AIM: The present study evaluates the performance of the POSSUM, the American Society of Anesthetists (ASA),APACHE and Childs classification in predicting mortality and morbidity in hepatopancreaticobiliary (HPB) surgery.We describe especially the limitations and advantages of risk in stratifying the patients.METHODS: We investigated 177 randomly chosen patients undergoing eledive complex HPB surgery in a single institution with a total of 71 pre-operative and intra-operative risk factors.Primary endpoint was in-hospital mortality and morbidity.Ordered logistic regression analysis was used to identify individual predictors of operative morbidity and mortality.RESULTS: The operative mortality in the series was 3.95% .This compared well with the p-POSSUM and APACHE predicted mortality of 4.31% and 4.29% respectively. Postoperative complications amounted to 45% with 24 (13.6%)patients having a major adverse event. On multivariate analysis the pre-operative POSSUM physiological score (OR = 1.18,P = 0.009) was superior in predicting complications compared to the ASA (P = 0.108), APACHE (P = 0.117)or Childs classification (P = 0.136). In addition, serum sodium, creatinine, international normalized ratio (INR),pulse rate, and intra-operative blood loss were independent risk factors. A combination of the POSSUM variables and INR offered the optimal combination of risk factors for risk prognostication in HPB surgery.CONCLUSION: Morbidity for elective HPB surgery can be accurately predicted and applied in everyday surgical practice as an adjunct in the process of informed consent and for effective allocation of resources for intensive and high-dependency care facilities. | Hemant M Kocher Paris P Tekkis Palepu Gopal Ameet G Patel Simon Cottam Irving S Benjamin | 2005 | World Journal of Gastroenterology2005，11，16： | 3 |
| 4 | Inhibition of tumor growth and metastatic spreading by overexpression of inter-alpha-trypsin inhibitor family chains显示文摘 | Paris S Sesboue R Delpech B | 2002 | Int J Cancer2002，97，5： | 2 |
| 5 | Novel biomarkers for patient stratification in colorectal cancer:A review of definitions,emerging concepts,and data显示文摘Colorectal cancer(CRC) treatment has become more personalised,incorporating a combination of the individual patient risk assessment,gene testing,and chemotherapy with surgery for optimal care.The improvement of staging with high-resolution imaging has allowed more selective treatments,optimising survival outcomes.The next step is to identify biomarkers that can inform clinicians of expected prognosis and offer the most beneficial treatment,while reducing unnecessary morbidity for the patient.The search for biomarkers in CRC has been of significant interest,with questions remaining on their impact and applicability.The study of biomarkers can be broadly divided into metabolic,molecular,micro RNA,epithelial-to-mesenchymal-transition(EMT),and imaging classes.Although numerous molecules have claimed to impact prognosis and treatment,their clinical application has been limited.Furthermore,routine testing of prognostic markers with no demonstrable influence on response to treatment is a questionable practice,as it increases cost and can adversely affect expectations of treatment.In this review we focus on recent developments and emerging biomarkers with potential utility for clinical translation in CRC.We examine and critically appraise novel imaging and molecular-based approaches; evaluate the promising array of micro RNAs,analyze metabolic profiles,and highlight key findings for biomarker potential in the EMT pathway. | Manish Chand Deborah S Keller Reza Mirnezami Marc Bullock Aneel Bhangu Brendan Moran Paris P Tekkis Gina Brown Alex Mirnezami Mariana Berho | 2018 | World Journal of Gastrointestinal Oncology2018，10，7： | 2 |
| 6 | Direct trajectory optimization using nonlinear programming and collocation显示文摘 | Hargraves C Paris S | 1987 | AIAA J Guidance and Control1987，10，： | 1 |
| 7 | Morphological and bond strength evaluation of different resin cements to root dentin显示文摘 | Bitter K Paris S Pfuertner C | 2009 | Eur J Oral Sci2009，117，3： | 1 |
| 8 | New dietetic recommendations in diabetes mellitus: the unplications in enteral mutrition显示文摘 | Sanz Paris A Gamboa RA Uson JP Celaya Perez S | 1995 | Nutr Hosp1995，10，3： | 1 |
| 9 | Stimulation of respiration by Pb^2+ in detached leaves and mitochondria of C3 and C4 plants 显示文摘 | Romanowska E Igamberdiev Au Pary S E Gardestrom P | 2002 | Physiol Plant2002，116，2： | 1 |
| 10 | Membrane bio -reactors for decentralized wastewater treatment and reuse显示文摘 | S Meuler S Paris T Hacker | | 0，，02： | 1 |
| 11 | influence of the application time on the penetration of different dental adhesives and a fissure sealant into artifical subsurface lesions in bovine enamel显示文摘 | Meyer-lueckel H Paris S Mueller J | | 0，，01： | 1 |
| 12 | A proposed subspecific classification for Cucurbita pepo 显示文摘 | Paris H S | 1986 | Phytologia1986，61，3： | 1 |
| 13 | Gene expression of humanbeta-defensins in healthy and inflamed human dental pulps显示文摘 | Paris S Wolgin M Kielbassa AM | 2009 | Bi-ology2009，35，4： | 1 |
| 14 | Dexmedetomidine increases hippocampal phosphorylated extracellular signalregulated protein kinase 1 and 2 content by an alpha 2adrenoceptorindependent mechanism:evidence for the involvement of imidazoline I1 receptors显示文摘 | DAHMANI S PARIS A JANNIER V | 2008 | Anesthesiology2008，108，3： | 1 |
| 15 | Cardiac autonomic neuropathy in diabetic patients: influence of diabetes duration, obesity, and microangiopathic complications-the French muhicenter study 显示文摘 | Valensi P Pariès J Attali JR | 2003 | Metabolism2003，52，： | 1 |
| 16 | Protective effect of thymol on high fat diet induced diabetic nephropathy in C57BL/6J mice显示文摘 | Saravanan S Pari L | 2016 | Chem Biol Interact2016，245，5： | 1 |
| 17 | Direct Trajectory Optimization Using Nonlinear Programming and Collocation 显示文摘 | Hargraves C R Paris S W | 1987 | Journal of Guidance Control and Dynamics (S0731-5090)1987，10，4： | 1 |
| 18 | Conidial hydrophobins of Aspergillus fumigates 显示文摘 | Paris S Debeaupuis JP Crameri R | 2003 | Appl Environ Microbiol2003，69，3： | 1 |
| 19 | Membrane bio-reactors for decentralized wastewater treatment and reuse显示文摘 | Meuler S Paris S Hackner T | 2008 | Water Sci Technol2008，58，2： | 1 |
| 20 | Erythromycin enhances fasting and postp randial proximal gastric tone in humans显示文摘 | Bruley des Varannes S Parys V Ropert A | 1995 | Gastroenterology1995，109，1： | 1 |
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