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| 1 | 美国国立老化研究所与阿尔茨海默病协会诊断指南写作组:阿尔茨海默病临床前阶段的定义显示文摘阿尔茨海默病(AD)的病理生理过程在痴呆诊断的多年前就开始了。这一长期的AD“临床前”阶段是治疗干预的关键机会,但需进一步阐明AD的病理级联过程和临床症状出现之间的联系。美国国立老化研究所和AD协会召集了一个国际工作组对AD生物标志物、流行病学和神经心理学的证据进行综述并提出建议,以确定能够预测由“正常”认知到轻度认知功能障碍(MCI)及AD痴呆的最佳预测指标。根据目前已有的主要科学证据,我们提出了一个概念性的框架和用于操作的研究标准,以通过纵向临床研究来验证和改进这些模型。这些建议仅用于研究目的,目前不涉及临床应用。我们希望这些建议能提供一个共识,以推进临床前AD的研究,最终推动更早期治疗干预的进展,使得一些疾病减缓药物的疗效发挥最大。 | Sperling RA Aisen PS Beckett LA Bennett DA Craft S Fagan AM Iwatsubo T Jack CR Jr Kaye J Montine TJ Park DC Reiman EM Rowe CC Siemers E Stern Y Yaffe K Carrillo MC Thies B Morrison-Bogorad M Wagster MV Phelps CH 贾建平(译) 郭起浩(译) 黄丽(译) 陆璐(译) 张逸驰(译) 邢怡(译) | 2012 | 中华神经科杂志2012，45，5： | 22 |
| 2 | Failure of intertrochanteric fracture fixation with adynamic hip screw in relation to pre operative fracture stability and osteoporosis 显示文摘 | Kim WY Han CH Park JI | 2001 | Int Orthop2001，25，6： | 1 |
| 3 | Intravitreal triamcinolone acetonide in eyes with cystoid macular edema associated with central rentinal vein occlusion显示文摘 | Park CH Jutffe GJ Fekrat S | 2003 | Am J Ophthalmol2003，136，： | 1 |
| 4 | Growth suppression of hmnan leukemic cells in vitro by ascorbic cacid显示文摘 | Park CH Amare M Savin MA | 1980 | Cancer Res1980，40，： | 1 |
| 5 | A comparison of arthroscopically assisted single and double bundle tibial inlay reconstruction for isolated posterior cruciate ligament injury显示文摘 | Shon OJ Lee DC Park CH | 2010 | Clin Orthop Surg2010，2，2： | 1 |
| 6 | Early surgical correction of atri- oventrieular valvular regurgitation in single-ventricle patients 显示文摘 | Kwak JG Park CS Lee CH | 2010 | Ann Thorac Surg2010，90，： | 1 |
| 7 | Hepcidin, a urinary antimierobial peptide synthesized in the liver 显示文摘 | Park CH Valore EV Waring A J | 2001 | J Biol Chem2001，276，： | 1 |
| 8 | An increase in rod blood cell distribu- tion width from baseline predicts mortality in patients with severe sepsis or septic shock显示文摘 | Kim CH Park JT Kim EJ | 2013 | Crit Care2013，17，6： | 1 |
| 9 | Failure of intertrochanteric fracturefixation with a dynamic hip screw in relation to preopreative fracturestability and osteoporosis显示文摘 | KimWY Han CH Park JI | 2001 | Int Orthop2001，25，6： | 1 |
| 10 | A Korean herbal medicine,Panax notoginseng,prevents liver fibrosis and hepatic microvascular dysfunction in rats显示文摘 | Park WH Lee SK Kim CH | 2005 | Life Sci2005，76，15： | 1 |
| 11 | The mycobacterial 38-kilodalton glycolipoprotein antigen activates the mitogen-activated protein kinase pathway and release of proinflammatory cytokines through Toll-like receptors 2 and 4 in human monocytes显示文摘 | Jung SB Yang CS Lee JS Shin AR Jung SS Son JW Har- ding CV Kim HJ Park JK Paik TH Song CH Jo EK | 2006 | Infect Immun2006，74，5： | 1 |
| 12 | Failure of intertro- chanteric fracture fixation with a dynamic hip screw in relation to pre - operative fracture stability and osteopo- rosis显示文摘 | Kim WY Han CH Park JI | 2001 | Int Orthop2001，25，6： | 1 |
| 13 | A prospective, randomized trial comparing mechanical methods of hemostasis plus epinephrine inject-tion to epinephrine injection alone for bleeding peptic ulcer显示文摘 | PARK CH JOO YE KIM HS | 2004 | Gastroi-ntest Endosc2004，60，： | 1 |
| 14 | Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin a suppressed TNF-alpha-induced fractalkine expression 显示文摘 | Ahn SY Cho CH Park KG et d | 2004 | Am J Pathol2004，164，5： | 1 |
| 15 | 显示文摘 | Park CH Bergsagel DE McCulloch EA | 1971 | J Natl Cancer Inst1971，46，： | 1 |
| 16 | Mouse myeloma tumor stem cell: a primary cell culture assay显示文摘 | Park CH Bergsagel DE McCulloch EA | 1971 | J Natl Cancer Inst1971，46，2： | 1 |
| 17 | Telomerase activity and telomere lengths in various cell lines:changes of telomerase activity can be another method for chemosensitivity evaluation显示文摘 | PARK KH RHA SY KIN CH | 1998 | Int J Oncol1998，13，： | 1 |
| 18 | H epeidin, a urinary antimicrobial peptide synthesized in the liver显示文摘 | Park CH Valore EV Waxing A J | 2001 | J Biol Chem2001，276，11： | 1 |
| 19 | Influence of thresholds on amplitudesin vestibular evoked myogenic potentials显示文摘 | Shin JE Kim CH Park HJ | 2013 | Auris Nasus Larynx2013，40，4： | 1 |
| 20 | Efficacy of low-dose ta- msulosin on lower urinary tract symptoms suggestive of benign prostatie hyperplasia显示文摘 | PARK CH CHANG HS OH BR | 2004 | Clin Drug Investig2004，24，： | 1 |
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