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| 1 | Predictors of spine deformity progression in adolescent idiopathic scoliosis: A systematic review with meta-analysis显示文摘AIM: To evaluate published data on the predictors of progressive adolescent idiopathic scoliosis(AIS) in order to evaluate their efficacy and level of evidence. METHODS: Selection criteria:(1) study design: randomized controlled clinical trials, prospective cohort studies and case series, retrospective comparative and none comparative studies;(2) participants: adolescents with AIS aged from 10 to 20 years; and(3) treatment: observation, bracing, and other. Search method: Ovid MEDLINE, Embase, the Cochrane Library, Pub Medand patent data bases. All years through August 2014 were included. Data were collected that showed an association between the studied characteristics and the progression of AIS or the severity of the spine deformity. Odds ratio(OR), sensitivity, specificity, positive and negative predictive values were also collected. A metaanalysis was performed to evaluate the pooled OR and predictive values, if more than 1 study presented a result. The GRADE approach was applied to evaluate the level of evidence.RESULTS: The review included 25 studies. All studies showed statistically significant or borderline association between severity or progression of AIS with the following characteristics:(1) An increase of the Cobb angle or axial rotation during brace treatment;(2) decrease of the rib-vertebral angle at the apical level of the convex side during brace treatment;(3) initial Cobb angle severity(> 25o);(4) osteopenia;(5) patient age < 13 years at diagnosis;(6) premenarche status;(7) skeletal immaturity;(8) thoracic deformity;(9) brain stem vestibular dysfunction; and(10) multiple indices combining radiographic, demographic, and physiologic characteristics. Single nucleotide polymorphisms of the following genes:(1) calmodulin 1;(2) estrogen receptor 1;(3) tryptophan hydroxylase 1;(3) insulin-like growth factor 1;(5) neurotrophin 3;(6) interleukin-17 receptor C;(7) melatonin receptor 1B, and(8) Scoli Score test. Other predictors included:(1) impairment of melatonin signaling in osteoblasts and peripheral blood mononuclear cells(PBMC);(2) G-protein signaling dysfunction in PBMC; and(3) the level of platelet calmodulin. However, predictive values of all these findings were limited, and the levels of evidence were low. The pooled result of brace treatment outcomes demonstrated that around 27% of patents with AIS experienced exacerbation of the spine deformity during or after brace treatment, and 15% required surgical correction. However, the level of evidence is also low due to the limitations of the included studies.CONCLUSION: This review did not reveal any methods for the prediction of progression in AIS that could be recommended for clinical use as diagnostic criteria. | Andriy Noshchenko Lilian Hoffecker Emily M Lindley Evalina L Burger Christopher MJ Cain Vikas V Patel Andrew P Bradford | 2015 | World Journal of Orthopedics2015，6，7： | 4 |
| 2 | Cardiac T2* Magnetic Resonance for Prediction of Cardiac Complications in Thalassemia Major显示文摘 | P Kirk M Roughton J B. Porter J M. Walker M A. Tanner J Patel D Wu J Taylor M A. Westwood L J. Anderson D J. Pennell | 2009 | Circulation2009，，20： | 1 |
| 3 | Novel human SR-BI antibodies prevent infection and dissemination of HCV in vitro and in humanized mice显示文摘 | Lacek K Vercauteren K Grzyb K Naddeo M Verhoye L Slowikowski M P Fafi-Kremer S Patel A H Baumert T F Folgori A Leroux-Roels G Cortese R Meuleman P Nicosia A | 2012 | J Hepatol2012，57，1： | 1 |
| 4 | New wine in old bottles: technological diffusion in developed economies显示文摘 | Robertson P L Patel P R | 2007 | Research Policy2007，，36： | 1 |
| 5 | The maize epicuticular wax layer provides UV protection显示文摘 | Long L M Patel H P Cory W C | 2002 | Functional Plant Biology2002，30，1： | 1 |
| 6 | Antigen-presenting property of mesenchymal stem cells occurs during a narrow window at low levels of interferon-gamma显示文摘 | Chan J L Tang K C Patel A P | 2006 | Blood2006，107，： | 1 |
| 7 | C-reactive protein and its relation to cardiovascular risk factor: a population based cross sectional study 显示文摘 | Mendall M A patel P Ballam L | 1996 | Bri Med J1996，312，7038： | 1 |
| 8 | Electronic effects on dislocation velocities in heavily doped silicon显示文摘 | PATEL J R TESTARDI L R FREELAND P E | 1976 | Physical Review B1976，13，8： | 1 |
| 9 | Polyethylene made with in situ supported ni-diimine/SMAO: replication phenomenon and effect of polymerization conditions on polymer microstructure and morphology 显示文摘 | Simon L C Patel H Soares J B P | 2001 | Macromol Chem Phys2001，202，17： | 1 |
| 10 | C reactive protein and relation to cadiovascular risk factors: a population based cross sectional study显示文摘 | Mendll MA Patel P Ballam L | 1996 | Br Med J1996，312，27： | 1 |
| 11 | Pulmonary embolism:optimization of small pulmonary artery visualization at multi-detectorrow CT显示文摘 | Patel S Kazerooni E L Cascade P N | 2003 | Radiology2003，227，2： | 1 |
| 12 | Risks of intravitreous injection: a comprehensive review 显示文摘 | JAGER R D AIELLO L P PATEL S C | 2004 | Retina2004，24，5： | 1 |
| 13 | Reactive protein and relation to cardiovascular risk factors : a population based cross sectional study显示文摘 | MENDALL M A PATEL P BALLAM L | 1963 | Br Med J1963，312，27： | 1 |
| 14 | New wine in old bottles Technological diffusion in developed economies显示文摘 | Robertson P L Patel P R | 2007 | Re-search Policy2007，，36： | 1 |
| 15 | C-reactive protein and its relation to cardiovascular-risk factors: a population based cross sectional study 显示文摘 | Mendall MA Patel P BaUam L | 1996 | BMJ1996，，312： | 1 |
| 16 | Acute kidney injury and aberrantplanar cell polarity induce cyst formation in mice lacking renal cilia显示文摘 | Patel V Li L Cobo-Stark P | 2008 | Hum Mol Genet2008，17，： | 1 |
| 17 | C Reactive protein and its relation to cardiovascular risk factors: a population based cross sectional study显示文摘 | Mendall MA Patel P Ballam L | 1996 | BMJ1996，312，7038： | 1 |
| 18 | High efficiency nondispersive reactor for two-phase reactions 显示文摘 | Jr Massingill J L Patel P N Guntupalli M | 2008 | Organic Process Research Development2008，12，4： | 1 |
| 19 | Succinylcholine-induced postoperative sore throat显示文摘 | CAPON L M BRUCE D L PATEL K P | 1983 | Anesthesiology1983，59，3： | 1 |
| 20 | C- reactie protein and its relation to cardiovascular risk factors: a population baded cross sectional study显示文摘 | Mendall M A Patel P Ballam L | 1996 | BMJ1996，312，3： | 1 |
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