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| 1 | Wnt signaling and Loxl2 promote aggressive osteosarcoma显示文摘Osteosarcoma(OS)is the most frequent primary malignant bone tumor in urgent need of better therapies.Using genetically modified mouse models(GEMMs),we demonstrate that Wnt signaling promotes c-Fos-induced OS formation via the actions of the collagen-modifying enzyme Loxl2.c-Fos/AP-1 directly regulates the expression of the Wnt ligands Wnt7b and Wnt9a in OS cells through promoter binding,and Wnt7b and Wnt9a in turn promote Loxl2 expression in murine and human OS cells through the transcription factors Zeb1 and Zeb2.Concordantly,inhibition of Wnt ligand secretion by inactivating the Wnt-less(Wls)gene in osteoblasts in c-Fos GEMMs either early or in a therapeutic setting reduces Loxl2 expression and progression of OS.Wls-deficient osteosarcomas proliferate less,are less mineralized and are enriched in fibroblastic cells surrounded by collagen fibers.Importantly,Loxl2 inhibition using either the pan-Lox inhibitor BAPN or a specific inducible shRNA reduces OS cell proliferation in vitro and decreases tumor growth and lung colonization in murine and human orthotopic OS transplantation models.Finally,OS development is delayed in c-Fos GEMMs treated with BAPN or with specific Loxl2 blocking antibodies.Congruently,a strong correlation between c-FOS,LOXL2 and WNT7B/WNT9A expression is observed in human OS samples,and c-FOS/LOXL2 co-expression correlates with OS aggressiveness and decreased patient survival.Therefore,therapeutic targeting of Wnt and/or Loxl2 should be considered to potentiate the inadequate current treatments for pediatric,recurrent,and metastatic OS. | Kazuhiko Matsuoka Latifa Bakiri Lena I.Wolff Markus Linder Amanda Mikels-Vigdal Ana Patiño-García Fernando Lecanda Christine Hartmann Maria Sibilia Erwin F.Wagner | 2020 | Cell Research2020，30，10： | 5 |
| 2 | 印度Ganga-Meghna-Brahmaputra平原及周围地区与孟加拉国地下水砷污染及其对健康影响的19年研究显示文摘基于近19年对印度Ganga—Meghna—Brahmaputra(简称GMB)平原(面积569749km^2,人口超过5亿)地下水砷污染的调查,可以确定印度Ganga—Brahmaputra平原(包括北方邦、比哈尔邦、恰尔康得邦、西孟加拉邦、阿萨姆邦)和孟加拉国普遍受到砷的污染。近期的调查研究也表明,除米佐拉姆邦外,其他各邦的地下水也受到不同程度的砷污染。至今为止.已对印度各邦和孟加拧国的175000份和50808份压把井水样进行了含砷量检测。并组织了一支包括皮肤科、神经科和妇产科医生在内的有经验的专家组,对上述地区125000人进行了临床检查,其中9%患有砷导致的皮肤病损症状。至今共采集分析了60000份生物样品。包括发样、指甲、尿样及皮肤鳞屑,其中80%的样品含砷量超过允许值,很多人由此受到砷的亚临床损害。在上述砷暴露地区.19000名儿童经过检查,近1100人患有砷导致的皮肤病损。该调查结果表明.儿童比成人更容易受到砷的毒性损害。在这种状况下.应着力解决饮水安全问题来减轻砷的苊害. | Ahamed S Hossain MA Mukharjee A Sengupta MK Das B Nayak B Pal A Mukherjee SC Pati S Dutta RN Saha KC Quamruzzaman Q Chakraborti D 付松波(译) 孙殿军(审校) | 2007 | 中国地方病学杂志2007，26，1： | 3 |
| 3 | Efficient metallization of magnetite concentrate by reduction with agave bagasse as a source of reducing agents显示文摘The reduction behavior and metallization degree of magnetite concentrate with agave bagasse were investigated in an inert atmosphere.The effects of temperature,biomass content,and residence time on reduction experiments and metallization degree were investigated by X-ray diffraction and scanning electron microscopy.Compared with other types of biomass,agave bagasse had lower contents of nitrogen,sulfur,and ash.X-ray diffraction analysis showed that the metallization degree improved with increasing temperature and biomass content.Complete metallization was achieved at 1100℃ for 30 min with 65:35 and 50:50 ratios of the magnetite concentrate to the agave bagasse.These results demonstrate that agave bagasse promotes the efficient metallization of magnetite concentrate without the external addition of a reducing agent.Therefore,this biomass is a technical suitable alternative to replace fossil fuels in steelmaking. | Diana Cholico-González NoemíOrtiz Lara Mario Alberto Sánchez Miranda Ricardo Morales Estrella Ramiro Escudero García Carlos ALeón Patiño | 2021 | International Journal of Minerals,Metallurgy and Materials2021，28，4： | 2 |
| 4 | Mixed state geometric phases,entangled systems,and local unitary transforma-tions显示文摘 | Pati A K SjOqvist E | 2003 | Phys Rev Lett2003，91，9： | 1 |
| 5 | Wavelet fuzzy combined approach for fault classification of a series-compensated transmission line显示文摘 | Pradhan A K Routray A Pati S | 2004 | IEEE Transactions on Power Delivery2004，19，4： | 1 |
| 6 | Biochemical Method for Extraction and Reuse of Protein and Chromium from Chrome Leather Shavings:A Waste to Wealth Approach显示文摘 | Pati A Chaudhary R Subramani S | | 0，，10： | 1 |
| 7 | Simultaneous mutations (A/G-418and C/T- 384) in the Apo(a) promoter of individuals with low Lp(a) levels显示文摘 | Pati N Rouf A Pati U | 2000 | Mol Genet Metab2000，69，2： | 1 |
| 8 | Serum Anti - Mtillerian Hor- mone levels in women with secondary amenorrhea显示文摘 | La Marca A Pati M Orvieto R | 2006 | Fertil Stefil2006，85，： | 1 |
| 9 | Wavelet fuzzy com- bined approach for fault classification of a series-compensated trans- mission line 显示文摘 | PRADHAN A K ROUTRAY A PATI S | 2004 | 1EEE Transactions on Power Delivery2004，19，4： | 1 |
| 10 | Executive functions and methylphenidate response in subtypes of attention-deficit/hyperactivity disorder显示文摘 | Gillian A O'Driscoll Lana Dépatie | 2005 | Biol Psychiatry2005，57，11： | 1 |
| 11 | Serum anti-m llerian hormone levels in women with secondary amenorrhea显示文摘 | Marca A L Pati M Orvieto R | 2006 | Fertility and Sterility2006，85，5： | 1 |
| 12 | Quantum superposition of multiple clones and the novel cloning machine显示文摘 | Pati A K | 1999 | Phys Rev Lett1999，，83： | 1 |
| 13 | Impossibility of deleting an unknown quantum state显示文摘 | Pati A K Braunstein S L | 2000 | Nature2000，，404： | 1 |
| 14 | Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma显示文摘 | Khakoo A Y Pati S Anderson S A | 2006 | Journal of Experimental Medicine2006，203，5： | 1 |
| 15 | Randomized trial of atorvaatatin for reduction of myocardial damage during coronary intervention results from the ARMYDA study 显示文摘 | PASCERI V PATI'I G NUSCA A | 2004 | Circulation2004，110，： | 1 |
| 16 | General impossible operations in quantum information显示文摘 | PATI A K | 2002 | Phys Rev A2002，66，06： | 1 |
| 17 | Gangrene and Fournier's gangrene显示文摘 | Paty R Smith A D | 1992 | Urol Clin North Am1992，19，1： | 1 |
| 18 | Kinetics of metallic silver leaching in the O2-thiosulfate system 显示文摘 | Rivera I Pati O F Roca A | 2015 | Hydrometallurgy2015，156，： | 1 |
| 19 | Surgical treatment of colorectal Cancer显示文摘 | GUILLEM J G PATY P B COHEN A M | 1997 | CA Cancer J Clin1997，47，2： | 1 |
| 20 | Fluid structure interaction for a pressure driv- en flow 显示文摘 | PATI A N | 2008 | Mathematical and Computer Modeling2008，47，12： | 1 |
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