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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O'Connor Rodica Pop-Bus | 2010 | The Lancet2010，，9739： | 2 |
| 3 | Enzyme-inked immunosorbent assay employing monoctonal antibody specific for deoxynivalenol ( Vomitoxin ) and several analogues显示文摘 | William L C James J P Patrick H L | 1988 | J Agric food ehem1988，36，： | 1 |
| 4 | 查看详情显示文摘 | Schuch R Garibian A Nygaard P Raymond S Araik G Hans H S Patrick J P Per N | | 0，，： | 1 |
| 5 | Investigating employee perceptions of a framework of safety culture maturity显示文摘 | MATTHEW L DIANNE P PATRICK H | 2006 | Safety Science2006，44，： | 1 |
| 6 | Fiber grating sensors 显示文摘 | A D Kersey M A Davis H J Patrick M LeBlanc K P Koo C G Askins M A Putnam E J Friebele | 1997 | Lightwave Technology1997，15，8： | 1 |
| 7 | Effect of redox potential and pH on arsenic speciation and solubility in a contaminated soil显示文摘 | Masscheleyn P H Dlaune R D Patrick W H | 1991 | Environmental Science and Technology1991，25，8： | 1 |
| 8 | Fenton-driven chemical regeneration of MTBE-spent GAC显示文摘 | Scott G H Patrick K J Wendell P E | 2005 | Water Research2005，39，10： | 1 |
| 9 | LPG wavelength compensated, polarised, amplified, reduced RIN, broadband fibre optic source for precision fibre optic gyroscopes显示文摘 | MOELLER R P PATRICK H J | 2001 | Electronics Letters2001，37，1： | 1 |
| 10 | Multiple independent emer- gences of type 2 vaccine-derived polioviruses during a large outbreak in northern Nigeria显示文摘 | Burns C C Shaw J Jorba J Bukbuk D Adu F Gumede N Pate M A Abanida E A Gasasira A Iber J Chen Q Vincent A Chenoweth P Henderson E Wannemuehler K Naeem A Umarni R N Nishimura Y Shimizu H Baba M Adeniji A Williams A J Kil- patrick D R Oberste M S Wassilak S G Tomori O Pallansch M A Kew O | 2013 | J Virol2013，87，9： | 1 |
| 11 | Effect of redox potential and pH on arsenic speciation and solubility in a contaminated soil 显示文摘 | Masscheleyn P H Delaune R D Patrick W H | 1991 | Environmental Science and Technology1991，25，： | 1 |
| 12 | LPG wavelength compensated,polarized, amplified, reduced RIN, broadband fibre optic source for precision fibre optic gyroscopes 显示文摘 | Patrick H J | 2001 | Electron Lett2001，37，1： | 1 |
| 13 | Authenticated encryption schemes with low communication显示文摘 | PATRICK H MARKUS M HOLGER P | 1994 | Electronics Letters1994，30，15： | 1 |
| 14 | Resistance of Human Hepatitis Delta Virus RNAs to Dicer Activity显示文摘 | PATRICK P JOHN M T | 2003 | J Virol2003，77，11： | 1 |
| 15 | Bacterial fatty acid biosynthesis:a genomics-driven target for antibacterial drug discovery显示文摘 | David J P Patrick V W David J H | 2001 | DDT2001，6，10： | 1 |
| 16 | Functional genomics and the biosynthesis of artemisinin显示文摘 | PATRICK S C KEAT H T DEVIN R P | 2007 | Phytochemistry2007，，68： | 1 |
| 17 | Iron availability and uptake by rice in acid sulfate soils显示文摘 | Moore P A Patrick W H Jr | 1989 | Soil Science Society of America Journal1989，53，2： | 1 |
| 18 | Fiber grating sensors显示文摘 | KERSEY A D DAVIS M A PATRICK H J LeBLANC M KOO K P ASKINS C G PUTNAM M A FRIEBELE E J | 1997 | Journal Lightwave Technology1997，15，8： | 1 |
| 19 | The effects of pH,redox,and salinity on metal release from contaminated sediment显示文摘 | GAMBRELL L P WIESEPAPE J B PATRICK W H | 1991 | Water Air and Soil Pollution1991，，5758： | 1 |
| 20 | Effect of intensive treatment of hyperglycaemia on microvascular outcomes in type 2 diabetes: an analysis of the ACCORD randomised trial显示文摘 | Faramarz Ismail-Beigi Timothy Craven Mary Ann Banerji Jan Basile Jorge Calles Robert M Cohen Robert Cuddihy William C Cushman Saul Genuth Richard H Grimm Bruce P Hamilton Byron Hoogwerf Diane Karl Lois Katz Armand Krikorian Patrick O’Connor Rodica Pop-Bus | 2010 | 2010 (9739)2010，，9739： | 1 |
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