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| 1 | 一种房颤风险评分系统的建立(Framingham心脏研究):基于社区的队列研究显示文摘背景房颤导致了发病率和病死率的显著上升。本研究旨在建立一种预测个体罹患房颤绝对风险的风险评分系统,并提供研究人员评价新危险因素的流程。方法作者评估了Framingham心脏研究中于1968年6月至1987年9月间进行了8044次检测的4764例参与者(55%为女性,年龄45~95岁)。此后,参与者被随访至房颤首发,随访期最长达10年。多变量Coxi回归确认出1(1年内罹患房颤的临床危险因素。次级分析纳入了常规超声心动图检测指标(5152例4参与者,7156次检测)对房颤风险进行再分层评估,并评价超声检测指标能否提高风险预测能力。结果4764例参与者中的457例4(10%)罹患房颤。年龄、性别、体重指数、收缩压、降压治疗、PR间期、有临床意义的心脏杂音及心力衰竭与房颤相关,并被纳入了风险评分模型(除体重指数P=0.08外,其余均为P〈0.05),模型的C统计量为0.78(95%CI0.76~0.80)。10年房颤风险随年龄变化:年龄〈65岁的人群中53例(1%)风险高于15%,而〉65岁的人群中为783例(27%)。为提高预测能力而纳入超声检测指标仅使模型C统计量略微增高,由0.78(95%C10.75~0.80)增至0.79(95%CI0.77~0.82:P=0.005)。超声心动图检测指标并不能改善风险再分层评估(P=0.18)。结论基于社区医疗中易得的临床因素建立的风险评分系统,有助于确认社区个体罹患房颤的风险,评估技术或标志物能否改善风险预测,以及针对高危个体采取预防措施。 | Renate B Schnabel Lisa M Sullivan Daniel Levy Michael J Pencina Joseph M Massaro Ralph B D'Agostino Sr Christopher Newton-Cheh Jennifer F Yamamoto Jared W Magnani Thomas M Tadros William B Kannel Thomas J Wang Patrick T Ellinor Philip A Wolf Ramachanclran S Vasan Emelia J Benjamin 黄刚(译) | 2009 | 世界临床医学2009，，9： | 2 |
| 2 | Relationships Between Coastal Tourism and ICM Sustainability in the Central Visayas Region of the Philippines 显示文摘 | Monika T Thielea Richard B Pollnac Patrick Christie | 2005 | Ocean & Coastal Management2005，，48： | 1 |
| 3 | Transcriptional regulation of praline biosynthesis in Medicago truncatula reveals developmental and environmental specific features显示文摘 | Patrick A Laurent T Nathalie B et ol | 2002 | Physiologia Plantarum2002，120，3： | 1 |
| 4 | The impact of pyrro lidine hydroxylation on the conformation of proline containing peptides显示文摘 | CAROL M T RENAUD H PATRICK J B | | 0，，： | 1 |
| 5 | A comparative study of dexmedetomidine with midazolam and midazolam alone for sedation during elective awake fiberoptic intubation显示文摘 | Bergese S D Patrick B S McSweeney T D | 2010 | J Clin Anesth2010，22，1： | 1 |
| 6 | Superplastic properties of an aluminum-based alloy after equal-channel angular pressing 显示文摘 | Wang J T Patrick B Serbon Xu Y Z | 2000 | Mat Res Soc Symp2000，601，： | 1 |
| 7 | Factors Influencing Pain Management by Nurses in Emer- gency Departments in Central Africa显示文摘 | Rampanjato R M Florence M Patrick N C Finucane B T | 2007 | Emerg Med J2007，24，7： | 1 |
| 8 | High Performance Liquid Chromatographic Determination of Flumetsulam, A Newly Developed Sulfonamide Herbicide in Soil 显示文摘 | Sundaram B Denis R L Patrick T H | 1996 | Journal of Chromatography A1996，746，： | 1 |
| 9 | Genetic variation in wild and hatchery stocks of the black pearl oyster, Pinctqda margatitifera, from Japan显示文摘 | Patrick D Wada K T Francoise B | 1993 | Aquaculture1993，110，： | 1 |
| 10 | Technology powerhouse or diluted competence: techniques for assessing mergers via patent analysis显示文摘 | Anthony B Patrick T | 2002 | R&D Management2002，32，1： | 1 |
| 11 | Microwave Characterization of Filled Polymers显示文摘 | Christian B Patrick Q Philippe T | 2001 | Journal of Applied Physics2001，89，8： | 1 |
| 12 | Occupational heat exposure and male fertility : A review 显示文摘 | Patrick T Louis B Luc M | 1998 | Human Reproduction1998，13，8： | 1 |
| 13 | Exploration of the Mechanism of Platinum(11)-Catalyzed C-F Activation: Characterization and Reactivity of Platinum(IV) Fluoroaryl Complexes Relevant to Catalysis显示文摘 | Wang T Keyes L Patrick B O | 2012 | Organometallics2012，31，4： | 1 |
| 14 | Reductive dehalogenation of chlorinated ethenes and halgenated ethanes by a highrate anaerobic enrichment culture显示文摘 | Valter T Tomas D D Patrick A B | 1994 | Environmental Science Technology1994，28，： | 1 |
| 15 | Technology power house or diluted competence:techniques for assessing mergers via patent analysis显示文摘 | Anthony B Patrick T | 2002 | R&D Management2002，32，1： | 1 |
| 16 | Mating systems in the Lapwing Vanelhts vanellus显示文摘 | David M B P PatricK S T Coulson J C | 1997 | Ibis1997，139，1： | 1 |
| 17 | Highly Regioselec-tive Alkyne Cyclotrimerization Catalyzed by TitaniumComplexes Supported by Proximally Bridged p-tert-Butyl-calix(4 ) arene Ligands 显示文摘 | Ozerov O V Ladipo F T Patrick B 0 | 1999 | J Am Chem Soc1999，121，34： | 1 |
| 18 | Antimicrobial resistanceand virulence genes of Escherichia coli isolates from swine in ontario显示文摘 | Patrick B Rebeccah T Carlton L | 2005 | Applied and Encironmental Microbiology2005，71，11： | 1 |
| 19 | Seismic stability analysis of piled embankments:A multiphase approach显示文摘 | Quang T S Ghazi H Patrick D B | | 0，，： | 1 |
| 20 | 显示文摘 | Weng L T Patrick B | 2000 | J Mol Catal A2000，155，： | 1 |
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