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| 1 | Pediatric functional constipation treatment with Bifi dobacterium-containing yogurt:A crossover,double-blind,controlled trial显示文摘AIM: To evaluate the treatment of pediatric functional chronic intestinal constipation (FCIC) with a probiotic goat yogurt. METHODS: A crossover double-blind formula-controlled trial was carried out on 59 students (age range: 5-15 years) of a public school in Belo Horizonte, MG, Brazil, presenting a FCIC diagnostic, according to Roma Ⅲ criteria. The students were randomized in two groups to receive a goat yogurt supplemented with 109 colony forming unit/mL Bifidobacterium longum (B.longum) (probiotic) daily or only the yogurt for a period of 5 wk (formula). Afterwards, the groups were intercrossed for another 5 wk. Defecation frequency, stool consistency and abdominal and defecation pain were assessed.RESULTS: Both treatment groups demonstrated improvement in defecation frequency compared to baseline. However, the group treated with probiotic showed most signif icant improvement in the f irst phase of the study. An inversion was observed after crossing over, resulting in a reduction in stool frequency when this group was treated by formula. Probiotic and formula improved stool consistency in the f irst phase of treatment, but the improvement obtained with probiotic was significantly higher (P = 0.03). In the second phase of treatment, the group initially treated with probiotic showed worseningstool consistency when using formula. However, the difference was not signif icant. A signif icant improvement in abdominal pain and defecation pain was observed with both probiotic and formula in the first phase of treatment, but again the improvement was more signif icant for the group treated with B. longum during phase I (P < 0.05). When all data of the crossover study were analyzed, significant differences were observed between probiotic yogurt and yogurt only for defecation frequency (P = 0.012), defecation pain (P = 0.046) and abdominal pain (P = 0.015). | Paula VP Guerra Luiza N Lima Tassia C Souza Vanessa Mazochi Francisco J Penna Andreia M Silva Jacques R Nicoli Elizabet V Guimares | 2011 | World Journal of Gastroenterology2011，17，34： | 25 |
| 2 | Collagen/hyaluronan based hydrogels releasing sulfated hyaluronan improve dermal wound healing in diabetic mice via reducing inflammatory macrophage activity显示文摘Sustained inflammation associated with dysregulated macrophage activation prevents tissue formation and healing of chronic wounds.Control of inflammation and immune cell functions thus represents a promising approach in the development of advanced therapeutic strategies.Here we describe immunomodulatory hyaluronan/collagen(HA-AC/coll)-based hydrogels containing high-sulfated hyaluronan(sHA)as immunoregulatory component for the modulation of inflammatory macrophage activities in disturbed wound healing.Solute sHA downregulates inflammatory activities of bone marrow-derived and tissue-resident macrophages in vitro.This further affects macrophage-mediated pro-inflammatory activation of skin cells as shown in skin ex-vivo cultures.In a mouse model of acute skin inflammation,intradermal injection of sHA downregulates the inflammatory processes in the skin.This is associated with the promotion of an anti-inflammatory gene signature in skin macrophages indicating a shift of their activation profile.For in vivo translation,we designed HA-AC/coll hydrogels allowing delivery of sHA into wounds over a period of at least one week.Their immunoregulatory capacity was analyzed in a translational experimental approach in skin wounds of diabetic db/db mice,an established model for disturbed wound healing.The sHA-releasing hydrogels improved defective tissue repair with reduced inflammation,augmented pro-regenerative macrophage activation,increased vascularization,and accelerated new tissue formation and wound closure. | Sophia Hauck Paula Zager Norbert Halfter Elke Wandel Marta Torregrossa Ainur Kakpenova Sandra Rother Michelle Ordieres Susann Räthel Albrecht Berg Stephanie Möller Matthias Schnabelrauch Jan C.Simon Vera Hintze Sandra Franz | 2021 | Bioactive Materials2021，6，12： | 7 |
| 3 | Eccentric training as a new approach for rotator cuff tendinopathy: Review and perspectives显示文摘Excessive mechanical loading is considered the major cause of rotator cuff tendinopathy. Although tendon problems are very common, they are not always easy to treat. Eccentric training has been proposed as an effective conservative treatment for the Achilles and patellar tendinopathies, but less evidence exists about its effectiveness for the rotator cuff tendinopathy. The mechanotransduction process associated with an adequate dose of mechanical load might explain the beneficial results of applying the eccentric training to the tendons. An adequate load increases healing and an inadequate(over or underuse) load can deteriorate the tendon structure. Different eccentric training protocols have been used in the few studies conducted for people with rotator cuff tendinopathy. Further, the effects of the eccentric training for rotator cuff tendinopathy were only evaluated on pain, function and strength. Future studies should assess the effects of the eccentric training also on shoulder kinematics and muscle activity. Individualization of the exercise prescription, comprehension and motivation of the patients, and the establishment of specific goals, practice and efforts should allbe considered when prescribing the eccentric training. In conclusion, eccentric training should be used aiming improvement of the tendon degeneration, but more evidence is necessary to establish the adequate doseresponse and to determine long-term follow-up effects. | Paula R Camargo Francisco Alburquerque-Sendín Tania F Salvini | 2014 | World Journal of Orthopedics2014，5，5： | 5 |
| 4 | Cytotoxicity and cellular accumulation of palladium(Ⅱ) complexes of tetracyclines显示文摘 | Paula F C Guerra W Silva I R | 2008 | Chem Biodivers2008，5，10： | 1 |
| 5 | Recovery of heat-injured Listeria innocua显示文摘 | FATIMA A MILLER T R S PAULA T | 2006 | International Journal of Food Microbiology2006，112，： | 1 |
| 6 | Carboxymethylation of cashew tree exudate polysaccharide显示文摘 | Silva D A de Paula R C Feitosa J P | 2004 | Carbohydrate Polymers2004，58，2： | 1 |
| 7 | Diagnosis and management of Duchenne muscular dystrophy, part 2: implementation of multidisciplinary care显示文摘 | Katharine Bushby Richard Finkel David J Birnkrant Laura E Case Paula R Clemens Linda Cripe Ajay Kaul Kathi Kinnett Craig McDonald Shree Pandya James Poysky Frederic Shapiro Jean Tomezsko Carolyn Constantin | 2010 | Lancet Neurology2010，，2： | 1 |
| 8 | Urinary 11-dehydro thromboxane B 2 levels in type 2 diabetic patients before and during aspirin intake显示文摘 | Lillian Harboe Gon?alves Luci Maria Sant'Ana Dusse Ana Paula Fernandes Karina Braga Gomes Mirelle Oliveira Sóter Michelle Teodoro Alves Kathryna Fontana Rodrigues Fernanda Rocha Freitas Flavia Komatsuzaki Marinez Oliveira Sousa Adriana Aparecida Bosco Gér | 2011 | Clinica Chimica Acta2011，，15： | 1 |
| 9 | Device selection and out- comes of aerosol therapy: Evience based guidelines 显示文摘 | Myma B Dean R Paula A | 2005 | Chest2005，127，1： | 1 |
| 10 | The in vivo effect of the administration of resistance-modulating agents on rhodamine 123 distribution in mice thymus and lymph nodes显示文摘 | MARQUES-SANTOS L F HARAB R C PAULA E F | 1999 | Cancer Lett1999，137，1： | 1 |
| 11 | Land-use and land- cover change in Alantic Forest landscapes显示文摘 | Paula K L Leandro R T Robert M E | 2012 | Forest Ecology and Management2012，278，： | 1 |
| 12 | Low-intensity laser therapy effect on the recovery of traumatic spinal cord injury 显示文摘 | Paula A A Nicolau R A Lima Mde O | 2014 | Lasers Med Sci2014，29，6： | 1 |
| 13 | Genetic control of the mitochondrial form of superoxide dismutase in hexaploid wheat显示文摘 | Paula R Neuman P R Hart G E | 1986 | Biochemical Genetics1986，24，56： | 1 |
| 14 | Cloning and sequence analysis of a lysophospholipase homologue from Schistosoma mansoni显示文摘 | Fadi F Hamdan Paula R | 1998 | Parasitol Res1998，84，： | 1 |
| 15 | University-industry collabo- ration and innovation in emergent and mature industries in new industrialized countries 显示文摘 | BODAS FREITASA I M ARGOU MARQUESC R MIR- RA DE PAULA E SILVAC E | 2013 | Research Policy2013，42，2： | 1 |
| 16 | Purification of guar gum for biological applications 显示文摘 | Cunha P L R Paula R Feitosa J | 2007 | International journal of biological macromolecules2007，41，3： | 1 |
| 17 | Combined solid-phase extraction and gas chromatography-mass spectrometry used for determination of chloropropanols in water显示文摘 | Paula G Inés R | | 0，，34： | 1 |
| 18 | Laboratory germination and sea out-planting of tetraspore progeny from Kappaphycus striatum(Rhodophyta) in subtropical waters of Brazil 显示文摘 | Bulboa C R de Paula E J Chow F | 2007 | J Appl Phycol2007，19，： | 1 |
| 19 | Tolerance to enteral nutri- tion therapy in traumatic brain injury patients 显示文摘 | Pinto TF Rocha R Paula CA | 2012 | Brain Inj2012，26，9： | 1 |
| 20 | Two circadian timing circuits in Neurospora crassa cells share components and regulate distinct rhythmic processes显示文摘 | DE PAULA R M LEWIS Z A GREENE A V | 2006 | J Biol Rhythms2006，21，3： | 1 |
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