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| 1 | Bile acids as endogenous etiologic agents in gastrointestinal cancer显示文摘Bile acids are implicated as etiologic agents in cancer of the gastrointestinal (GI) tract, including cancer of the esophagus, stomach, small intestine, liver, biliary tract, pancreas and colon/rectum. Deleterious effects of bile acid exposure, likely related to carcinogenesis, include: induction of reactive oxygen and reactive nitrogen species; induction of DNA damage; stimulation of mutation; induction of apoptosis in the short term, and selection for apoptosis resistance in the long term. These deleterious effects have, so far, been reported most consistently in relation to esophageal and colorectal cancer, but also to some extent in relation to cancer of other organs. In addition, evidence is reviewed for an association of increased bile acid exposure with cancer risk in human populations, in specific human genetic conditions, and in animal experiments. A model for the role of bile acids in GI carcinogenesis is presented from a Darwinian perspective that offers an explanation for how the observed effects of bile acids on cells contribute to cancer development. | Harris Bernstein Carol Bernstein Claire M Payne Katerina Dvorak | 2009 | World Journal of Gastroenterology2009，15，27： | 38 |
| 2 | The high-molecular-weight subunits of glutenin:structure,genetics and relationship to bread-making quality显示文摘 | Payne P I Harris P A Law C N Holt L M Blackman J A | 1980 | Ann Technol Agric1980，29，2： | 2 |
| 3 | Evidence for colorectal sarcomatoid carcinoma arising from tubulovillous adenoma显示文摘Sarcomatoid carcinomas of the colorectum are rare tu- mors that display both malignant epithelial and stromal components. Clinically, they are aggressive tumors with early metastasis. Due to their infrequent occurrence, the pathogenesis is poorly understood. We report a case of a 52-year-old woman who presented with a rectal mass and intermittent hematochezia. Superficial biopsies during colonoscopy revealed a tubulovillous adenoma with high-grade dysplasia. Endoscopic ultra- sonography confirmed an invasive nature of the mass, and deeper biopsies revealed the presence of neoplasm with mixed histological components. The surgically- excised specimen demonstrated the presence of poorly differentiated spindle cells underneath the tubulovillous adenoma and an intermediate stage of invasive adeno- carcinoma. Based on the histological appearance and immunohistochemical studies, a diagnosis of sarcoma- toid carcinoma was made. Only nine cases of sarcoma- toid carcinomas of the colorectum have been reported to date. As a result, the terminology and pathogenesis of sarcomatoid carcinoma remain speculative. To the best of our knowledge, this is the first report of co- existence of sarcomatoid carcinoma and invasive ad- enocarcinoma with tubulovillous adenoma; all stages represented within the same tumor. This observation supports the 'monoclonal theory' of pathogenesis with an adenoma-sarcoma progression with or without an intermediate stage of carcinoma. | Jeffrey K Lee Pradipta Ghosh Valerie McWhorter Misty Payne Ryan Olson Mary L Krinsky Sonia Ramamoorthy John M Carethers | 2008 | World Journal of Gastroenterology2008，14，27： | 2 |
| 4 | Constructive consumer choice processes 显示文摘 | Bettman J R Luce M F Payne J W | 1998 | Journal of Consumer Research1998，，25： | 1 |
| 5 | HPRS-103 (exogenous avian leukosis virus, subgroup J) has an env related to those of endogenous elements EAV-0 and E51 and E element found previously only in sarcoma virus显示文摘 | BAI J PAYNE L N SKINNER M A | 1995 | J Wirol1995，69，2： | 1 |
| 6 | Finite Basis Set Corrections to Total Energy Pseudopotential Calculations显示文摘 | Francis G P Payne M C | 1990 | J Phys Condens Matter1990，2，19： | 1 |
| 7 | Iterative minimization techniques for ab initio total-energy calculations: Molecular dynamics and conjugate gradients 显示文摘 | PAYNE M C TETER M P ALLAN D C | 1992 | Rev Mod Phys1992，64，4： | 1 |
| 8 | Ensemble density-functional theory for ab-initio molecular dynamicsof metals and finite-temperature insulators 显示文摘 | MARZARI N VANDERBILT D PAYNE M C | 1997 | Physical Review Letters1997，79，7： | 1 |
| 9 | Effects of feeding frequency and rate of stomach evacuation on utilization of dietary free and protein-bound lysine for growth by channel catfish Ictalurus punctatus显示文摘 | ZARATE D D LOVELL R T PAYNE M | 1999 | Aquaculture Nutrition1999，5，： | 1 |
| 10 | Clinical paths for cardiac surgery patients a multidisciplinary approach to quality improvement outcomes显示文摘 | Rudisill P Phillips M Payne C M | 1994 | Journal of Hospital Quality Management1994，，8： | 1 |
| 11 | Molecular neurology; implications for insecticide action and resistance显示文摘 | Soderlund D M Payne L L Knipple D C | 1989 | Pestic Sci1989，26，4： | 1 |
| 12 | Relativistic nuclear magnetic resonance chemical shifts of heavy nuclei with pseudopotentials and the zeroth-order regular approximation显示文摘 | Yates J R Pickard C J Payne M C | 2003 | J Chem Phys2003，118，13： | 1 |
| 13 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 14 | First-principles simulation: Ideas, illustrations and the CASTEP code 显示文摘 | SEGALL M D L1NDAN P J D PROBERT M J PICKARD C J HASNIP P J CLARK S J PAYNE M C | 2002 | Journal of Physics: Condensed Matter2002，14，11： | 1 |
| 15 | Constructive consumer choice processes显示文摘 | Bettman J R Luce M F and Payne J W | 1998 | Journal of Consumer Research1998，25，3： | 1 |
| 16 | Mapping groundwater contamination using DC resistivity and VLF geophysical methods: a case study 显示文摘 | BensonA K Payne K L Stubben M A | 2001 | Geophysics2001，62，1： | 1 |
| 17 | Bernoulli operator:A low-level approach to log-domain processing显示文摘 | DRAKAKIS E M PAYNE A J TOUMAZOU C | 2007 | Electronics Letters2007，33，12： | 1 |
| 18 | Sequence data suggests big liver and spleen disease virus (BLSV) is genetically related to hepatitis E virus 显示文摘 | Payne C J Ellis T M Plant S L | 1999 | Veterinary Microbiology1999，68，： | 1 |
| 19 | Optimized and Transferable Nonlocal Separable ab initio Pseudopotentials 显示文摘 | Lin J S Qteish A Payne M C | 1993 | Phys Rev B1993，47，： | 1 |
| 20 | Stability of insecticide resistance in the peach-potato aphid Myzus persicar (Sulze)显示文摘 | SAWICKI R M DEVONSHIRE A L PAYNE R W | 1980 | Pestic Sci1980，11，： | 1 |
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