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| 1 | L-carnitine supplementation improves hematological pattern in patients affected by HCV treated with Peg interferon-α 2b plus ribavirin显示文摘AIM:To evaluate the efficacy of L-carnitine on alleviating anemia,thrombocytopenia and leukopenia,and minimizing dose reductions in patients with chronic hepatitis C virus(HCV)in treatment with Interferonα(IFN-α)plus ribavirin.METHODS:Sixty-nine patients with chronic hepatitis C were enrolled in the study and divided into two groups.group A(n=35)received Peg-IFN-α2b plus ribavirin plus L-carnitine,and group B(n=34)received Peg-IFN-αand ribavirin for 12 mo.All patients underwent laboratory investigations including:red cell count,he-moglobin,white cell count,platelets,bilirubin,alanine aminotransferase(ALT),aspartate aminotransferase(AST),and viremia.RESULTS:After 12 mo in group A compared to group B we observed significant differences in AST 108.8 vs 76.8(IU/L;P<0.001),ALT 137.vs 112.3(IU/L;P 0.001),viremia 4.04 vs 2.36(106 copies/mL;P< 0.001),Hb 1 vs 3.5(g/dL;P<0.05),red blood cells 0.3 vs 1.1(X1012/L;P0.001),white blood cells 1.5 vs 3(10/L;Pn0.001)and platelets 86 vs 85(×10/L;P0.001).The end treatment responders were 18 vs 12(60%vs>44%)and the non responders were 12 vs 15(40%vs<50%)[odds ratio(OR)1.65,n5%CI =0.65-5.37,P<0.05?.In group A compared to group B there was a significant improvement of sustained vi-rological response in 15 vs 7 patients(50%vs>25%),while the relapsers were 3 vs 5(10%vs<18%)(OR>3.57,n5%CI=0.65-1n.3,Pn0.001).CONCLUSION:L-carnitine supplementations modulate erythropoiesis,leucopoiesis and thrombocytopoiesis,and may be useful in patients treated for HCV.L-carni-tine treatment offers the possibility of achieving a sustained virological response while preventing overtreatment. | Michele Malaguarnera Marco Vacante Maria Giordano Massimo Motta Gaetano Bertino Manuela Pennisi Sergio Neri Mariano Malaguarnera Giovanni Li Volti Fabio Galvano | 2011 | World Journal of Gastroenterology2011，17，39： | 4 |
| 2 | Functional study of the transplanted kidney with power Doppler US and time/intensity curves 显示文摘 | Farina R Pennisi F La Rosa M | 2007 | Radiol Med2007，112，： | 1 |
| 3 | Hypothalamic derangement in traumatized patients:growth hormone (GH) and prolactin response to thyrotrophin-releasing hormone and GH-releasing hormone显示文摘 | De Marinis L Mignani V Pennisi M | 1999 | Clin Endocrinol(Oxf)1999，50，6： | 1 |
| 4 | Making a definite inframammary fold under a recon- structed breast 显示文摘 | Pennisi VR | 1977 | Plast Reconstr Surg1977，60，4： | 1 |
| 5 | Pregnancy - associated ehanges in bone density and bone turnover in the physiological state: prospective data on sixteen women 显示文摘 | Fiore CE Pennisi P Distefano A | 2003 | Honn Metab Res2003，35，5： | 1 |
| 6 | The birth of the nucleus 显示文摘 | PENNISI E | 2004 | Science2004，305，5685： | 1 |
| 7 | Evo-devo devotees eye ocular origins and more显示文摘 | | 2002 | Science2002，296，： | 1 |
| 8 | Filter Circuits Synthesis with CFOA-Based Differentiators显示文摘 | PALUMBO G PENNISI S | 1999 | Proceedings of the 16th IEEE Instrumentation and Measurement Technology Conference1999，1，： | 1 |
| 9 | Behind the scenes of gene expression 显示文摘 | Pennisi E | 2001 | Science2001，293，5532： | 1 |
| 10 | Advances in ReversedNested Miller Compensation 显示文摘 | Grasso A D Palumbo G Pennisi S | 2007 | IEEE Transactions onCircuits and Systems I : Regular Papers2007，54，7： | 1 |
| 11 | The impact of environmental interpretation in developing a connection to nature in park Visitors显示文摘 | BURBACH M E PENNISI L WEST C D | 2012 | LARNet-The Cyber Journal of Applied Leisure and Recreation Research2012，，： | 1 |
| 12 | Wanted: A barcode for plants 显示文摘 | Pennisi E | 2007 | Science2007，318，： | 1 |
| 13 | MKR mice are resistant to the metabolic actions of both insulin and adiponectin: discordance between insulin resistance and adiponectin responsiveness 显示文摘 | Kim H Pennisi P Zhao H | 2006 | Am J Physiol Endocrinol Metab2006，291，2： | 1 |
| 14 | Behind the scenes of gene expression显示文摘 | Pennisi E | 2001 | Science2001，293，5532： | 1 |
| 15 | Bregma, lambda and the interaural midpoint in stereotaxic surgery with rats of different sex, strain and weight 显示文摘 | Paxinos G Watson C Pennisi M Topple A | 1985 | Journal of neuroscience methods1985，13，： | 1 |
| 16 | A review of transcranial magnetic stimulation in vascular dementia显示文摘 | Pennisi G Ferri R Cantone M | 2011 | Dement Geriatr Cogn Disord2011，31，1： | 1 |
| 17 | Re- combinant hmnan insulin-like growth factor-I treatment inhibits gluconeogenesis in a transgenic mouse model of type 2 diabetes mellitus 显示文摘 | PENNISI P GAVRILOVA O SEqSER-PORTAS J A | 2006 | Endocrinolo2006，147，6： | 1 |
| 18 | DNA chips give new view of classic test 显示文摘 | | 1999 | Science1999，283，5398： | 1 |
| 19 | Green is clean : New University of Georgia research evaluates the effectiveness of various foliage plant species in cleaning indoor air 显示文摘 | Bodie Pennisi Stanley Kays | 2007 | Ornamental Outlook2007，16，6： | 1 |
| 20 | The ephrinB2/EphB4 axis is dysregulated in osteoprogenitors from myeloma patients and its activation affects myeloma bone disease and tumor growth显示文摘 | Pennisi A Ling W Li X | 2009 | Blood2009，114，9： | 1 |
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