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| 1 | Efficient IL-2R signaling differentially affects the stability,function,and composition of the regulatory T-cell pool显示文摘Signaling via interleukin-2 receptor(IL-2R)is a requisite for regulatory T(Treg)cell identity and function.However,it is not completely understood to what degree IL-2R signaling is required for Treg cell homeostasis,lineage stability and function in both resting and inflammatory conditions.Here,we characterized a spontaneous mutant mouse strain endowed with a hypomorphic Tyr129His variant of CD25,theα-chain of IL-2R,which resulted in diminished receptor expression and reduced IL-2R signaling.Under noninflammatory conditions,Cd25Y129H mice harbored substantially lower numbers of peripheral Treg cells with stable Foxp3 expression that prevented the development of spontaneous autoimmune disease.In contrast,Cd25^(Y^(129H))Treg cells failed to efficiently induce immune suppression and lost lineage commitment in a T-cell transfer colitis model,indicating that unimpaired IL-2R signaling is critical for Treg cell function in inflammatory environments.Moreover,single-cell RNA sequencing of Treg cells revealed that impaired IL-2R signaling profoundly affected the balance of central and effector Treg cell subsets.Thus,partial loss of IL-2R signaling differentially interferes with the maintenance,heterogeneity,and suppressive function of the Treg cell pool. | Marc Permanyer Berislav Bošnjak Silke Glage Michaela Friedrichsen Stefan Floess Jochen Huehn Gwendolyn E.Patzer Ivan Odak Nadine Eckert Razieh Zargari Laura Ospina-Quintero Hristo Georgiev Reinhold Förster | 2021 | Cellular & Molecular Immunology2021，18，2： | 2 |
| 2 | Assessment of quality of life retated to health 2 years after coronary surgery显示文摘 | Permanyer MG Brotons C Cascant P | 1997 | Med Clin Barc1997，108，12： | 1 |
| 3 | Fluid flow record from frac- ture-fill calcite in the Eocene limestones from the South-Pyrenean Basin (NE Spain)and its relationship to oil shows 显示文摘 | Caja M A Permanyer A Marfil R | 2006 | Journal of Ge- ochemical Exploration2006，89，13： | 1 |
| 4 | Linking organic geochemistry, oil shows, oil fluid inclusions and tectonic structure to unravel oil migration history (SE Pyrenees Spain)显示文摘 | Caja M A Permanyer A | 2009 | Journal of Geochemical Exploration2009，101，14： | 1 |
| 5 | Facies-related diagenesis and multiphase siderite cementation and dissolu- tion in the reservoir sandstones of the Khatatba Formation, Egypt western desert 显示文摘 | Carlos R Rafaela M Karl R Permanyer A | 2001 | J Sediment Res2001，71，3： | 1 |
| 6 | Tuberevlovs pericarditis:Ten year experience with a prospective protocol for diagnosis and treatment显示文摘 | Sagrsta SJ Permanyer MG Soler SJ | 1998 | J Am Coll Cardioi1998，11，4： | 1 |
| 7 | Long term results of mechanical prostheses for treatment of active infective endocarditis显示文摘 | Guerra J Tomos M Permanyer Miralda G | 2001 | Heart2001，86，： | 1 |
| 8 | Autosomal recessive retinitis pigmentosa with early macular affectation caused by premature truncation in PROM1 显示文摘 | Permanyer J Navarro R Friedman J | 2010 | Invest Ophthalmol Vis Sci2010，51，： | 1 |
| 9 | Significance of organic matter in Eo- cene turbidite sediments (SE Pyrenees, Spain)显示文摘 | Caja M A Permanyer A | 2008 | Naturwis- sensehaften2008，95，11： | 1 |
| 10 | Infective endocarditis in Europe :lessons from the Euro heart survey 显示文摘 | Tornos P Iung B Permanyer - Miralda G | 2005 | Heart2005，91，： | 1 |
| 11 | assessment of quality of life related to health 2years after coronary surgery显示文摘 | Permanyer MG Brotons C Cascant P | 1997 | Med Clin bare1997，108，12： | 1 |
| 12 | Fluid Flow Record from Fracture-fill Calcite in the Eocene Limestones from the South-Pyrenean Basin (NE Spain) and Its Relationship to Oil Shows 显示文摘 | CAJA M A PERMANYER A MARFIL R | 2006 | Journal of Geochemical Exploration2006，89，13： | 1 |
| 13 | lubercvlovs Pericarditis: ten Year experience with a prospective protocol for diagnosis and treatment显示文摘 | Sagrsta SJ Permanyer MG Soler 5J | 1998 | J Am Coll Cardiol1998，11，4： | 1 |
| 14 | Assessment of quality of life retated to health 2 years after coronary surgery显示文摘 | Permanyer MG Brotons C Cascant P | 1997 | Med Clin Barc1997，108，12： | 1 |
| 15 | Crude oil biodegradation and environmental factors at the Riutort oil shale mine, SE Pyrenees 显示文摘 | Permanyer A Gallego J L R Caja M A | 2010 | Journal of Petroleum Geology2010，33，2： | 1 |
| 16 | Crude oil biodegradation and environmental factors at the Riutort oil shale mine,SE Pyrenees显示文摘 | Permanyer A Gallego J L R Caja M A | 2010 | Journal of Petroleum Geology2010，33，2： | 1 |
| 17 | Comparison of perceived health status and conventional functional evaluation in stable patients with coronary artery disease显示文摘 | Permanyer G Alonso J Alijarde-Guimera M | 1991 | J Clin Epidemiol1991，44，： | 1 |
| 18 | Long term results of mechanical prostheses for treatment of active infective endocarditis 显示文摘 | Guerra JM Tornos MP Permanyer MG Almirante B Murtra M | 2001 | Heart2001，86，1： | 1 |
| 19 | Maintenance of breast milk immunoglobulin A after high-pressure processing显示文摘 | Permanyer M Castellote C Ramirez-Santana C | 2010 | J Dairy Sci2010，93，3： | 1 |
| 20 | Clinical outcome and health related quality of life in patients undergoing coronary angioplasty with balloon or stent: A prospective multicenter study显示文摘 | Permanyer MC Brotons CC Ribera SA | 2001 | Rev Esp Cardiol2001，54，5： | 1 |
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