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| 1 | Glu-1和Glu-3等位变异对小麦加工品质的影响显示文摘Glu 1位点等位基因编码的高分子量麦谷蛋白亚基 (HMW GS)和Glu 3位点等位基因编码的低分子量麦谷蛋白亚基 (LMW GS)是决定小麦加工品质的重要因素。用优质面包小麦中优 95 0 7的两个杂交组合 ,即中优 95 0 7/鲁麦 5号和中优 95 0 7/晋麦 4 5F5代 ,澳大利亚优质面包小麦Sunstate的两个杂交组合 ,即Sunstate/济南 16和Sunstate/鲁麦 2 1F2 代 ,研究了Glu 1和Glu 3位点等位变异对小麦加工品质的影响。结果表明 ,当材料为非 1BL/1RS易位系时 ,位点对小麦加工品质的贡献大小为Glu D1>Glu A3≥Glu B1;当材料为 1BL/1RS易位系时 ,位点对小麦加工品质的贡献大小为Glu B3>Glu D1>Glu A1。 1BL/1RS易位对SDS沉降值、和面时间和耐揉性均有显著负面影响。就单个亚基而言 ,Glu A1位点 1>N ,Glu B1位点 17+18>7+8>7+9,Glu D1位点 5 +10 >2 +12、3+12和 4 +12 ,Glu A3位点GluA3d和GluA3b >Glu A3a ,Glu B3位点GluB3d >GluB3b和GluB3h >GluB3j。亚基组合为 1、7+9、5 +10、GluA3d、GluB3b和 1、7+8、5 +10、Glu A3d、GluB3d的材料 ,加工品质优良 ,亚基组合为 1、7+8、2 +12、GluA3a、GluB3d和N、7+9、3+12、GluA3d、GluB3j的材料加工品质较差。 | 刘丽 周阳 何中虎 阎俊 张艳 Pea R J | 2004 | 作物学报2004，30，10： | 54 |
| 2 | 软质小麦品质性状与酥性饼干品质参数的关系研究显示文摘选用我国17份软质小麦品种(系)在3点种植2年,研究软质小麦品质性状与酥性饼干品质的关系,探讨优质饼干品种的筛选指标。结果表明,粉质仪和拉伸仪参数与饼干品质的相关系数较小;吹泡仪弹性、吹泡仪弹性,延伸性、碱水保持力(AWRC)、碳酸钠溶剂保持力(SRC)和蔗糖SRC与饼干直径关系密切,相关系数分别为-0.79、-0.75、-0.78、-0.79和-0.80,可作为饼干品质的筛选指标。筛选出建麦1号、皖麦19和皖麦48三个饼干品质优良的品种,提出了优质饼干小麦品种的具体品质指标,即籽粒硬度(SKCS)1~40,籽粒蛋白质含量9.0%~11.5%,面粉蛋白质含量8.0%~10.0%,吹泡仪弹性≤40mm,弹性,延伸性≤0.50,吹泡仪能量≤75×10^-4J,碱水保持力≤59%,水SRC≤53%,碳酸钠SRC≤66%,乳酸SRC≤83%,蔗糖SRC≤87%,饼干直径≥480mm。 | 张岐军 张艳 何中虎 R J Pea | 2005 | 作物学报2005，31，9： | 58 |
| 3 | 不同加水量对北方馒头加工品质影响的研究显示文摘加水量是影响馒头加工品质的重要因素。用3种不同筋力的6个小麦面粉和5个水平加水量研究了加水量与北方馒头品质的关系。结果表明,在粉质仪测定的吸水率范围内,加水量显著影响馒头重量、体积、宽度、高度、比容及延展率。不同筋力面粉的馒头品质对加水量变化的敏感性不同。加水量与弱筋馒头表面亮度、色泽、光滑度、结构、压缩张弛性及总评分呈显著或极显著负相关(r=-0.663~-0.962),但在一定范围内,加水量增加能显著改善强筋馒头表面光滑度和内部结构(r=0.877,0.768)。强、中、弱筋面粉制作北方馒头的最适加水量分别为粉质仪吸水率(FWA)的85%、80%和70%~75%。压缩张弛性(SR)与强、中、弱筋馒头总评分呈极显著正相关,决定系数分别为0.94、0.88和0.72,可作为馒头品质评价的有效指标。 | 陈东升 张艳 何中虎 王德森 Pea R J | 2005 | 作物学报2005，31，6： | 28 |
| 4 | 肥胖患者的冠状动脉微血管功能障碍和心血管病风险显示文摘全世界有〉5亿的肥胖人群,其心血管病风险增加的病理生理机制是复杂的,并且可能涉及脂肪细胞相关因子的过量分泌,导致血管氧化应激增加,神经激素活性上调,以及低度全身炎症,可能导致交感神经系统激活增加,血管张力改变,冠状动脉微血管功能障碍(coronary microvascular dysfunction, CMD) 。 | Bajaj NS Osborne MT Gupta A Tavakkoli A Bravo PE Vita T Bibbo CF Hainer J Dorbala S Blankstein R Bhatt DL Di Carli MF Taqueti VR 刘青 叶鹏 | 2018 | 中华高血压杂志2018，26，9： | 11 |
| 5 | Haplotype of prostaglandin synthase 2/cyclooxygenase 2 is involved in the susceptibility to inflammatory bowel disease显示文摘AIM: Prostaglandin G/H synthase 2 (PTGS2 or COX2) is one of the key factors in the cellular response to inflammation.PTGS2 is expressed in the affected intestinal segments of patients with inflammatory bowel diseases (IBD). In IBD patients, non-steroidal anti-inflammatory drugs, which have been shown to reduce both the production and activity of PTGS2, may activate IBD and aggravate the symptoms.We aimed at examining genetic variants of PTGS2 that may be risk factors for IBD.METHODS: We genotyped 291 individuals diagnosed with IBD and 367 controls from the Dutch population for the five most frequent polymorphisms of the PTGS2 gene.Clinical data were collected on all patients. DNA was extracted via normal laboratory methods. Genotyping was carried out using multiplex PCR followed by the Invader Assay and the 5' exonuclease assay (TaqMan). New polymorphism screening was performed by pre-screening with denaturing high-performance liquid chromatography,followed by fluorescent sequencing.RESULTS: Allele 5209G was weakly associated with Crohn's disease (odds ratio [OR] 1.63, 95% confidence interval [CI] 1.03-2.57), and allele 8473T with ulcerative colitis (OR 1.50, 95%CI 1.00-2.27). The haplotype including both alleles showed a strong association with IBD (OR 13.15, 95%CI 3.17-116.15). This haplotype, while rare (-0.3%) in the general population, is found more frequently in patients (3.5%).CONCLUSION: Our data suggest that this haplotype of PTGS2 contributes to the susceptibility of IBD. | David G Cox J Bart A Crusius Petra HM Peeters H Bas Bueno-de-Mesquita A Salvador Pe(n|~)a Federico Canzian | 2005 | World Journal of Gastroenterology2005，11，38： | 10 |
| 6 | CIMMYT小麦puroindoline基因型的进一步鉴定与分析显示文摘目的籽粒硬度是小麦市场分级和定价的重要依据,影响磨粉和食品加工品质。CIMMYT是我国最重要小麦引种地之一,研究其硬度基因型对我国小麦引种具有重要的应用价值。方法以CIMMYT常用的236份小麦亲本和高代品系为材料,采用改进的颗粒指数法、特异引物的PCR扩增和改进的SDS-PAGE凝胶电泳对其SKCS硬度及其puroindoine基因型进行鉴定和分析。结果202份硬质麦中,165份为PINA蛋白缺失类型;37份为Pinb-D1b类型,其中19份为非CIMMYT材料,18份亲本中均含有非CIMMYT材料。在34份软质麦中,有野生型、Pina-D1a/Pinb-D1i、Pina-D1c/Pinb-D1h、Pina-D1j/Pinb-D1i和Pina-D1a/Pinb-D1j共5种基因型。两种硬质类型中,Pina-D1b类型胚乳硬质程度明显高于(PSI硬度显著低于)Pinb-D1b类型;4种软质类型中,Pina-D1c/Pinb-D1h和Pina-D1a/Pinb-D1i类型胚乳硬质程度显著高于(PSI硬度显著低于)Pina-D1j/Pinb-D1i和Pina-D1a/Pinb-D1a类型。通过分析各类型的puroindoline基因序列发现,Pinb-D1h和Pinb-D1i编码同一种氨基酸,突变后仍表现为软质是因为第28位精氨酸变成色氨酸,其余软质变异类型色氨酸丰富区附近均未发生变化,这可能是导致其胚乳质地仍未变硬的主要原因。结论在先前研究基础上,本试验对CIMMYT小麦基因型作了进一步分析,发现系谱中没有外源材料的所有CIMMYT硬质麦均为Pina-D1b类型。从山羊草引进的软质突变类型之间存在一定硬度差异。 | 陈锋 夏先春 Manila William Morten Lillemo Richard Trethowan Roberto J Peňa 何中虎 | 2006 | 中国农业科学2006，39，8： | 6 |
| 7 | Effects of cellulase and xylanase enzymes mixed with increasing doses of Salix babylonica extract on in vitro rumen gas production kinetics of a mixture of corn silage with concentrate显示文摘An in vitro gas production(GP) technique was used to investigate the effects of combining different doses of Salix babylonica extract(SB) with exogenous fibrolytic enzymes(EZ) based on xylanase(X) and cellulase(C), or their mixture(XC; 1:1 v/v) on in vitro fermentation characteristics of a total mixed ration of corn silage and concentrate mixture(50:50, w/w) as substrate. Four levels of SB(0, 0.6, 1.2 and 1.8 m L g–1 dry matter(DM)) and four supplemental styles of EZ(1 μL g–1 DM; control(no enzymes), X, C and XC(1:1, v/v) were used in a 4×4 factorial arrangement. In vitro GP(m L g–1 DM) were recorded at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation process was stopped and supernatant p H was determined, and then filtered to determine dry matter degradability(DMD). Fermentation parameters, such as the 24 h gas yield(GY24), in vitro organic matter digestibility(OMD), metabolizable energy(ME), short chain fatty acid concentrations(SCFA), and microbial crude protein production(MCP) were also estimated. Results indicated that there was a SB?EZ interaction(P<0.0001) for the asymptotic gas production(b), the rate of gas production(c), GP from 6 to 72 h, GP2(P=0.0095), and GP4(P=0.02). The SB and different combination of enzymes supplementation influenced(P<0.001) in vitro GP parameters after 12 h of incubation; the highest doses of SB(i.e., 1.8 m L g–1 DM), in the absence of any EZ, quadratically increased(P<0.05) the initial delay before GP begins(L) and GP at different incubation times, with lowering b(quadratic effect, P<0.0001) and c(quadratic effect, P<0.0001; linear effect, P=0.0018). The GP was the lowest(P<0.05) when the highest SB level was combined with cellulose. There were SB?EZ interactions(P<0.001) for OMD, ME, the partitioning factor at 72 h of incubation(PF72), GY24, SCFA, MCP(P=0.0143), and p H(P=0.0008). The OMD, ME, GY24 and SCFA with supp lementation of SB extract at 1.8 m L g–1 DM were higher(P<0.001) than the other treatments, however,PF72 was lower(quadratic effect, P=0.0194) than the other levels. Both C and X had no effect(P>0.05) on OMD, p H, ME, GY24, SCFA and MP. The combination of SB with EZ increased(P<0.001) OMD, ME, SCFA, PF72 and GP24, whereas there was no impact on p H. It could be concluded that addition of SB extract, C, and X effectively improved the in vitro rumen fermentation, and the combination of enzyme with SB extract at the level of 1.2 m L g–1 was more effective than the other treatments. | Abdelfattah Z M Salem German Buendía-Rodríguez Mona M M Elghandour María A Mariezcurrena Berasain Francisco J Pea Jiménez Alberto B Pliego Juan C V Chagoyán María A Cerrillo Miguel A Rodríguez | 2015 | Journal of Integrative Agriculture2015，14，1： | 4 |
| 8 | Retrospective analysis of old-age colitis in the Dutch inflammatory bowel disease population显示文摘AIM: To describe the characteristics of Dutch patients with chronic inflammatory bowel disease (IBD) first diagnosed above 60 years of age-a disease also known as old-age colitis (OAC) and to highlight a condition that has a similar appearance to IBD, namely segmen- tal colitis associated with diverticular disease (SCAD). METHODS: A retrospective longitudinal survey of patient demographic and clinical characteristics, disease characteristics, diagnostic methods, management and course of disease was performed. The median follow-up period was 10 years. RESULTS: Of a total of 1100 IBD patients attending the Department of Gastroenterology, 59 (5%) [median age 82 years (range 64-101); 25 male (42%)] were identified. These patients were diagnosed with ulcerative colitis (n = 37, 61%), Crohn’s disease (n = 14, 24%), and indeterminate colitis (n = 8, 15%). Remission was induced in 40 (68%) patients within a median interval of 6 mo (range 1-21) and immunosuppressive therapy was well tolerated. Histological evaluation based on many biopsy samples and the course of the disease led to other diagnosis, namely SCAD instead of IBD in five (8%) patients. CONCLUSION: OAC is not an infrequent problem for the gastroenterologist, and should be considered in the evaluation of older patients with clinical featuressuggestive of IBD. Extra awareness and extensive biopsy sampling are required in order to avoid an erroneous diagnosis purely based on histological mimicry of changes seen in SCAD, when diagnosing IBD in the presence of diverticulosis coli. | Muhammed Hadithi Marcel Cazemier Gerrit A Meijer Elisabeth Bloemena Richel J Felt-Bersma Chris J Mulder Stephan GM Meuwissen Amado Salvador Pea Adriaan A van Bodegraven | 2008 | World Journal of Gastroenterology2008，14，20： | 3 |
| 9 | Effect of B vitamin supplementation on plasma homocysteine levels in celiac disease显示文摘AIM: To investigate the effect of vitamin supplements on homocysteine levels in patients with celiac disease. METHODS: Vitamin B6, folate, vitamin B12, and fasting plasma homocysteine levels were measured in 51 consecutive adults with celiac disease [median (range) age 56 (18-63) years; 40% men, 26 (51%) had villous atrophy, and 25 (49%) used B-vitamin supplements] and 50 healthy control individuals matched for age and sex. Finally, the C677T polymorphism of 5,10-methylene tetrahydrofolate reductase (MTHFR) was evaluated in 46 patients with celiac disease and all control individuals. RESULTS: Patients with celiac disease and using vitamin supplements had higher serum vitamin B6 (P = 0.003),folate (P < 0.001), and vitamin B12 (P = 0.012) levels than patients who did not or healthy controls (P = 0.035, P < 0.001, P = 0.007, for vitamin B6, folate, and vitamin B12, respectively). Lower plasma homocysteine levels were found in patients using vitamin supplements than in patients who did not (P = 0.001) or healthy controls (P = 0.003). However, vitamin B6 and folate, not vitamin B12, were significantly and independently associated with homocysteine levels. Twenty-four (48%) of 50 controls and 23 (50%) of 46 patients with celiac disease carried the MTHFR thermolabile variant T-allele (P = 0.89). CONCLUSION: Homocysteine levels are dependent on Marsh classification and the regular use of B-vitamin supplements is effective in reduction of homocysteine levels in patients with celiac disease and should be considered in disease management. | Muhammed Hadithi Chris JJ Mulder Frank Stam Joshan Azizi J Bart A Crusius Amado Salvador Pea Coen DA Stehouwer Yvo M Smulders | 2009 | World Journal of Gastroenterology2009，15，8： | 3 |
| 10 | 日粮中添加氨基酸降低粗蛋白含量对6~15kg仔猪生产性能的影响显示文摘为评价添加氨基酸降低粗蛋白(CP)含量对6~15 kg仔猪的影响,共设计两个试验。在性能试验中(试验Ⅰ),21日龄、初始体重为5.95±0.33 kg的断奶仔猪120头被分成5组。试验为完全随机区组试验设计,共8个重复,每个重复3只猪。在5个处理组中,CP含量由21.0%降低到15.0%(分别为21.0%,19.5%,18.0%,16.5%和15.0%),通过添加L-赖氨酸、DL-蛋氨酸、L-苏氨酸、L-色氨酸、L-缬氨酸和L-异亮氨酸来满足日粮中氨基酸的需求。各处理间生产性能无显著差异。因此,以上蛋白质的任何水平都能被有效的合成氨基酸。降低蛋白质的含量可以增加必需氨基酸和非必需氨基酸的比值,且蛋白质含量为15%时比值最佳(5347)。随着蛋白质含量的降低,尿素含量线性下降(试验Ⅰ)。为评估氮平衡(试验Ⅱ),21日龄的杂交阉割商品仔猪20只被随机分成5组,仔猪的平均活重为10.79±2.19kg。5个处理组的所有动物安置在铁笼中,每个处理4个重复,每个重复1只猪。结果血液和尿液中尿素含量随蛋白质含量的减少线性降低(P〈0.05),进而减少了动物向环境中的氮排泄。 | Toledo J B Furlan A C Pozza P C Pianob L M Carvalho P L O Peuela-Sierra L M Huepa L M D | 2014 | 饲料博览2014，0，11： | 3 |
| 11 | 模拟教学在继续医学教育中的应用探讨显示文摘目前,模拟技术在院校医学教育和毕业后医学教育以及其他医疗卫生专业人员的个人训练和评估中有广泛的应用,模拟技术能给各种技术水平的医疗卫生专业人员提供安全、有效的实践机会,帮助他们学会治疗患者所需的临床技能。有越来越多的研究证实了模拟技术对于医疗卫生专业人员的培训效果。然而,在继续医学教育领域,模拟技术还未得到广泛的应用。 | McGaghie WC Siddall VJ Mazmanian PE Myers J | 2012 | 中国继续医学教育2012，4，2： | 2 |
| 12 | 年龄≥65岁男性收缩压与血管疾病的相关性显示文摘老年人血压与血管疾病的关系尚不确定。1996-1999年,在澳大利亚西部帕斯普通人群中建立65~94岁男性7564人的前瞻性队列,评估收缩压与主要血管事件的相关性。测定基线和2001-2004年再调查时的收缩压。记录受试者的致命性及非致命性血管事件。 | Lacey B Golledge J Yeap BB Lewington S McCaul KA Norman PE Flicker L Almeida OP Hankey GJ 赵狄 练桂丽 | 2017 | 中华高血压杂志2017，25，5： | 2 |
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| 14 | Diffuse venous malformations of the upper limb:morphologie characterization by MRI and venography显示文摘 | Upton J Burrows PE | 2001 | Pediatr Radiol2001，31，7： | 1 |
| 15 | Advances in the preparation of magnetic nanoparticles by the microemulsion method显示文摘 | LO' PEZ PE' REZ J A LO' PEZ QUINTELA M A MIRA J | 1997 | J Phys Chem B1997，101，41： | 1 |
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