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| 1 | Diagnostic and prognostic potential of tissue and circulating long non-coding RNAs in colorectal tumors显示文摘Long non-coding RNAs(lncRNAs)are members of the non-protein coding RNA family longer than 200 nucleotides.They participate in the regulation of gene and protein expression influencing apoptosis,cell proliferation and immune responses,thereby playing a critical role in the development and progression of various cancers,including colorectal cancer(CRC).As CRC is one of the most frequently diagnosed malignancies worldwide with high mortality,its screening and early detection are crucial,so the identification of disease-specific biomarkers is necessary.LncRNAs are promising candidates as they are involved in carcinogenesis,and certain lncRNAs(e.g.,CCAT1,CRNDE,CRCAL1-4)show altered expression in adenomas,making them potential early diagnostic markers.In addition to being useful as tissue-specific markers,analysis of circulating lncRNAs(e.g.,CCAT1,CCAT2,BLACAT1,CRNDE,NEAT1,UCA1)in peripheral blood offers the possibility to establish minimally invasive,liquid biopsy-based diagnostic tests.This review article aims to describe the origin,structure,and functions of lncRNAs and to discuss their contribution to CRC development.Moreover,our purpose is to summarise lncRNAs showing altered expression levels during tumor formation in both colon tissue and plasma/serum samples and to demonstrate their clinical implications as diagnostic or prognostic biomarkers for CRC. | Orsolya Galamb Barbara K Barták Alexandra Kalmár Zsófia B Nagy Krisztina A Szigeti Zsolt Tulassay Peter Igaz Béla Molnár | 2019 | World Journal of Gastroenterology2019，25，34： | 18 |
| 2 | Probiotic effects on intestinal fermentation patterns in patients with irritable bowel syndrome显示文摘AIM: To determine whether Lactobacillus casei strain Shirota (Yakult ) can alter small intestinal bacterial overgrowth (SIBO), as tested by the lactulose breath test, and whether this is associated with changes in symptoms in irritable bowel syndrome (IBS). METHODS: 18 patients with IBS (Rome Ⅱ criteria), who showed an early rise in breath hydrogen with lactulose (ERBHAL), consumed 65 mL of Yakult daily for 6 wk. Lactulose breath test was repeated at the end of the treatment period. Symptoms were recorded daily using a 10 cm visual analogue scale. RESULTS: 14 patients completed the study, 9 (64%) had reversal of ERBHAL, with the median time of f irst rise in breath hydrogen increasing from 45 to 75 min (P = 0.03). There was no signifi cant improvement in the symptom score with probiotic therapy, except for wind (P=0.04). Patients commencing with at least moderate symptoms and who no longer had ERBHAL at the end of treatment, showed improvement in the overall symptoms scores [median fi nal score 5.3 (IQR3.9-5.9), 55% reduction; n=6] to a greater extent than those who had had persisting ERBHAL [final score 6.9 (5.0-7.0), 12% reduction; n = 5; P = 0.18]. CONCLUSION: Yakult is effective in altering fermentation patterns in the small bowel, consistent with reducing SIBO. The loss of ERBHAL was associated with reduced symptoms. The true interpretation of these fi ndings awaits a randomised, controlled trial. | Jacqueline S Barrett Kim EK Canale Richard B Gearry Peter M Irving Peter R Gibson | 2008 | World Journal of Gastroenterology2008，14，32： | 16 |
| 3 | Dietary advanced glycation end-products aggravate non-alcoholic fatty liver disease显示文摘AIM To determine if manipulation of dietary advanced glycation end product(AGE), intake affects nonalcoholic fatty liver disease(NAFLD) progression and whether these effects are mediated via RAGE. METHODS Male C57Bl6 mice were fed a high fat, high fructose, high cholesterol(HFHC) diet for 33 wk and compared with animals on normal chow. A third group were given a HFHC diet that was high in AGEs. Another group was given a HFHC diet that was marinated in vinegar to prevent the formation of AGEs. In a second experiment, RAGE KO animals were fed a HFHC diet or a high AGE HFHC diet and compared with wildtype controls. Hepatic biochemistry, histology, picrosirius red morphometry and hepatic mR NA were determined. RESULTS Long-term consumption of the HFHC diet generated significant steatohepatitis and fibrosis after 33 wk. In this model, hepatic 4-hydroxynonenal content(a marker of chronic oxidative stress), hepatocyte ballooning, picrosirius red staining, α-smooth muscle actin and collagen type 1A gene expression were all significantly increased. Increasing the AGE content of the HFHC diet by baking further increased these markers of liver damage, but this was abrogated by pre-marination in acetic acid. In response to the HFHC diet, RAGE-/-animals developed NASH of similar severity to RAGE+/+ animals but were protected from the additional harmful effects of the high AGE containing diet. Studies in isolated Kupffer cells showed that AGEs increase cell proliferation and oxidative stress, providing a likely mechanism through which these compounds contribute to liver injury. CONCLUSION In the HFHC model of NAFLD, manipulation of dietary AGEs modulates liver injury, inflammation, and liver fibrosis via a RAGE dependent pathway. This suggests that pharmacological and dietary strategies targeting the AGE/RAGE pathway could slow the progression of NAFLD. | Christopher Leung Chandana B Herath Zhiyuan Jia Sof Andrikopoulos Bronwyn E Brown Michael J Davies Leni R Rivera John B Furness Josephine M Forbes Peter W Angus | 2016 | World Journal of Gastroenterology2016，22，35： | 7 |
| 4 | Management of Hyperglycemia in Type 2 Diabetes: A Patient-Centered Approach: Position Statement of the American Diabetes Association (ADA) and the European Association for the Study of Diabetes (EASD)显示文摘 | Inzucchi Silvio E Bergenstal Richard M Buse John B Diamant Michaela Ferrannini Ele Nauck Michael Peters Anne L Tsapas Apostolos Wender Richard Matthews David R | 2012 | EN2012，，3： | 6 |
| 5 | EGF promotes mammalian cell growth by suppressing cellular senescence显示文摘 | Peter B Alexander Lifeng Yuan Pengyuan Yang Tao Sun Rui Chen Handan Xiang Jiekai Chen Haoyu Wu Daniel R Radiloff Xiao-Fan Wang | 2015 | Cell Research2015，25，1： | 3 |
| 6 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 7 | How should liver hypertrophy be stimulated?A comparison of upfront associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)and portal vein embolization(PVE)with rescue possibility显示文摘Background:The role of associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)in comparison to portal vein embolization(PVE)is debated.The aim of this study was to compare successful resection rates(RR)with upfront ALPPS vs.PVE with rescue ALPPS on demand and to compare the hypertrophy of the liver between ALPPS and PVE plus subsequent rescue ALPPS.Methods:A retrospective analysis of all patients treated with PVE for colorectal liver metastasis(CRLM)or ALPPS(any diagnosis,rescue ALPPS included)at five Scandinavian university hospitals during the years 2013-2016 was conducted.A Chi-square test and a Mann-Whitney U test were used to assess the difference between the groups.A successful RR was defined as liver resection without a 90-day mortality.Results:A total of 189 patients were included.Successful RR was in 84.5%of the patients with ALPPS upfront and in 73.3%of the patients with PVE and rescue ALPPS on demand(P=0.080).The hypertrophy of the future liver remnants(FLRs)with ALPPS upfront was 71%(48-97%)compared to 96%(82-113%)after PVE and rescue ALPPS(P=0.010).Conclusions:Upfront ALPPS offers a somewhat higher successful RR than PVE with rescue ALPPS on demand.The sequential combination of PVE and ALPPS leads to a higher overall degree of hypertrophy than upfront ALPPS. | Ernesto Sparrelid Kristina Hasselgren Bård Ingvald Røsok Peter Nørgaard Larsen Nicolai Aagaard Schultz Ulrik Carling Eva Fallentin Stefan Gilg Per Sandström Gert Lindell Bergthor Björnsson | 2021 | Hepatobiliary Surgery and Nutrition2021，10，1： | 2 |
| 8 | The GPS code software receiver at Aalborg University 显示文摘 | NICOLAJ B KAI B PETER R | 1991 | Electronics Letters1991，，： | 1 |
| 9 | Cellulose biosynthesis and function in bacteria显示文摘 | Peter R RaphaeJ M Moshe B | 1991 | Micro1991，55，1： | 1 |
| 10 | The effect of short-term swiss ball training on core stability and running economy显示文摘 | Stanton R Peter R R Humphries B | 2004 | Journal of strength and condi- tioning Association2004，18，3： | 1 |
| 11 | Stabilization and Preser- vation of Lactobacillus Acidophilus in Saccharide Matrices显示文摘 | PAUL B C MILLER D P PETER R C | 2000 | Cryobiology2000，41，1： | 1 |
| 12 | Hepatocyte transplantation;potentioal of hepatocyte progenitor cells and bone marrow deriverd stem cells显示文摘 | Stieger B Peters R Sidler MA | 2006 | Swiss Med Wkly2006，136，3536： | 1 |
| 13 | Seed yield and agronomic traits of old and modem soybean cultivars under irrigation and soil water-deficit显示文摘 | Frederick J R Woolley J T Hesketh J D Peters D B | 1991 | Field Crops Research1991，27，： | 1 |
| 14 | Glutamine and the Bowel 显示文摘 | Peter J R Douglas G B | 2001 | J Nutr2001，131，： | 1 |
| 15 | Severity of symp- toms in primary dysmenorrheal: a Doppler study显示文摘 | Dmitrovic R Peter B Cvitkovic-kuzmic A | 2003 | Eur J Obstet Gynecol Reprod Biol2003，107，： | 1 |
| 16 | Design of a single frequency GPS software receiver 显示文摘 | PETER R NICOLAJ B | 2004 | Aalborg University2004，，： | 1 |
| 17 | Histochemical, biochemical and contractile properties of red, white and intermediate fibres显示文摘 | Barnard R J Edgerton V R Furukawa T Peter J B | 1971 | American Journal of Physiology1971，220，： | 1 |
| 18 | 3D reconstruction of the carotid artery from two views using a single centerline显示文摘 | Kenneth R H Alan M W Peter B N | 2004 | International Congress Series2004，，： | 1 |
| 19 | Earliest gestational age for fetal sexing in cell-free maternal plasma显示文摘 | Rijnders R J van der Luijt R B Peters E D Goeree J K Van Der Schoot C E Ploos Van Amstel J K | 2003 | Prenat Diagn2003，23，： | 1 |
| 20 | Metabolic profiles of three fiber types of skeletal muscle in guinea pigs and rabbits 显示文摘 | Peter J B Barnard R J Edgerton V R Gillespie C A Stemple K E | 1972 | Biochemistry1972，11，： | 1 |
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