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| 1 | Mass Spectrometry-based Quantitative Proteomic Profiling of Human Pancreatic and Hepatic Stellate Cell Lines显示文摘The functions of the liver and the pancreas differ; however, chronic inflammation in both organs is associated with fibrosis. Evidence suggests that fibrosis in both organs is partially regulated by organ-specific stellate cells. We explore the proteome of human hepatic stellate cells (hHSC) and human pancreatic stellate cells (hPaSC) using mass spectrometry (MS)-based quantitative proteomics to investigate pathophysiologic mechanisms. Proteins were isolated from whole cell lysates of immortalized hHSC and hPaSC. These proteins were tryptically digested, labeled with tandem mass tags (TMT), fractionated by OFFGEL, and subjected to MS. Proteins significantly different in abundance (P < 0.05) were classified via gene ontology (GO) analysis. We identified 1223 proteins and among them, 1222 proteins were quantifiable. Statistical analysis determined that 177 proteins were of higher abundance in hHSC, while 157 were of higher abundance in hPaSC. GO classification revealed that proteins of relatively higher abundance in hHSC were associated with protein production, while those of relatively higher abundance in hPaSC were involved in cell structure. Future studies using the methodologies established herein, but with further upstream fractionation and/or use of enhanced MS instrumentation will allow greater proteome coverage, achieving a comprehensive proteomic analysis of hHSC and hPaSC. | Joao A.Paulo Vivek Kadiyala Peter A.Banks Darwin L.Conwell Hanno Steen | 2013 | Genomics, Proteomics & Bioinformatics2013，11，2： | 2 |
| 2 | Effect of Physician Training on Fluoroscopy Time During ERCP显示文摘 | Lance T. Uradomo Mark E. Lustberg Peter E. Darwin | 2006 | Digestive Diseases and Sciences2006，，5： | 2 |
| 3 | 美国临床生化科学院检验医学实践指南:心血管疾病和卒中一级预防中新的生物标志物 第5章 脂蛋白(a)与心血管疾病危险显示文摘对脂蛋白(a)的建议
根据对已发表文献的全面综述,提出以下CHD和卒中一级预防危险评估时Lp(a)临床应用和检测建议。 | Gerald R.Cooper Peter W.F.Wilson Gary L.Myers Scott M.Grundy Darwin R.Labarthe 李江 郑芳 鄢盛恺 | 2013 | 临床检验杂志2013，31，5： | 2 |
| 4 | Cross‐species analysis of nicotine‐induced proteomic alterations in pancreatic cells显示文摘 | Joao A. Paulo Raul Urrutia Vivek Kadiyala Peter Banks Darwin L. Conwell Hanno Steen | 2013 | Proteomics2013，，9： | 1 |
| 5 | Lactated Ringer’s Solution Reduces Systemic Inflammation Compared With Saline in Patients With Acute Pancreatitis显示文摘 | Bechien U. Wu James Q. Hwang Timothy H. Gardner Kathryn Repas Ryan Delee Song Yu Benjamin Smith Peter A. Banks Darwin L. Conwell | 2011 | Clinical Gastroenterology and Hepatology2011，，8： | 1 |
| 6 | Evaluation of Subepithelial Abnormalities of the Appendix by Endoscopic Ultrasound显示文摘 | Lance T. Uradomo Peter E. Darwin Benjamin Kuttikatt Poulose | 2009 | Diagnostic and Therapeutic Endoscopy2009，，： | 1 |
| 7 | Proteomic analysis of a rat pancreatic stellate cell line using liquid chromatography tandem mass spectrometry (LC-MS/MS)显示文摘 | Joao A. Paulo Raul Urrutia Peter A. Banks Darwin L. Conwell Hanno Steen | 2011 | Journal of Proteomics2011，，2： | 1 |
| 8 | The usefulness of S100P, mesothelin, fascin, prostate stem cell antigen, and 14‐3‐3 sigma in diagnosing pancreatic adenocarcinoma in cytological specimens obtained by endoscopic ultrasound guided fine‐needle aspiration显示文摘 | Daniel C. Dim Feng Jiang Qi Qiu Ting Li Peter Darwin William H. Rodgers Hong Qi Peng | 2014 | Diagn Cytopathol2014，，3： | 1 |
| 9 | Appendiceal Mucocele Diagnosed in Patients with Inflammatory Bowel Disease Using Endoscopic Ultrasound显示文摘 | Uni Wong Peter Darwin S. Kennedy | 2012 | Case Reports in Medicine2012，，： | 1 |
| 10 | Reactions of sodium species in the promoted SNCR process显示文摘 | Vladimir M Zamansky Vitali V Lissianski Peter M Maly Loc Ho Darwin Rusli William C Gardiner | 1999 | Combustion and Flame1999，，4： | 1 |
| 11 | Human Ehlers-Danlos Syndrome Type VII C and Bovine Dermatosparaxis Are Caused by Mutations in the Procollagen I N-Proteinase Gene显示文摘 | Alain Colige Aleksander L. Sieron Shi-Wu Li Ulrike Schwarze Elizabeth Petty Wladimir Wertelecki William Wilcox Deborah Krakow Daniel H. Cohn W. Reardon Peter H. Byers Charles M. Lapière Darwin J. Prockop Betty V. Nusgens | 1999 | The American Journal of Human Genetics1999，，2： | 1 |
| 12 | Reactions of sodium species in the promoted SNCR process显示文摘 | Vladimir M Zamansky Vitali V Lissianski Peter M Maly Loc Ho Darwin Rusli William C Gardiner | 1999 | Combustion and Flame1999，，4： | 1 |
| 13 | Reactions of sodium species in the promoted SNCR process显示文摘 | Vladimir M Zamansky Vitali V Lissianski Peter M Maly Loc Ho Darwin Rusli William C Gardiner | 1999 | Combustion and Flame1999，，4： | 1 |
| 14 | Temporary placement of a fully covered metal stent to tamponade bleeding from endoscopic papillary balloon dilation显示文摘 | Florence Aslinia Lauren Hawkins Peter Darwin Eric Goldberg | 2012 | Gastrointestinal Endoscopy2012，，4： | 1 |
| 15 | Presaeral sehwannoma diagnosed by EUS-guided FNA 显示文摘 | Patrick E Young Scott Oosterveen Nader Hanna Peter E Darwin | 2008 | Gastrointestinal endoscopy2008，67，2： | 1 |
| 16 | Reactions ofsodium species in the promoted SNCR process 显示文摘 | Vladimir M Zamansky Vitali V Lissianski Peter M Maly Loc Ho Darwin Rusli William C Gardiner Jr | 1999 | Combustion and Flame1999，117，4： | 1 |
| 17 | Early Changes in Blood Urea Nitrogen Predict Mortality in Acute Pancreatitis显示文摘 | Bechien U. Wu Richard S. Johannes Xiaowu Sun Darwin L. Conwell Peter A. Banks | 2009 | Gastroenterology2009，，1： | 1 |
| 18 | An Assessment of the Severity of Interstitial Pancreatitis显示文摘 | Vikesh K. Singh Thomas L. Bollen Bechien U. Wu Kathryn Repas Rie Maurer Song Yu Koenraad J. Mortele Darwin L. Conwell Peter A. Banks | 2011 | Clinical Gastroenterology and Hepatology2011，，12： | 1 |
| 19 | Early Changes in Blood Urea Nitrogen Predict Mortality in Acute Pancreatitis显示文摘 | Bechien U. Wu Richard S. Johannes Xiaowu Sun Darwin L. Conwell Peter A. Banks | 2009 | Gastroenterology2009，，1： | 1 |
| 20 | Time-limited fluoroscopy to reduce radiation exposure during ERCP: a prospective randomized trial 显示文摘 | Lance T. Uradomo Eric M. Goldberg Peter E. Darwin | 2007 | Gastrointestinal Endoscopy2007，，1： | 1 |
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