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| 1 | Ghrelin and gastrin in advanced gastric cancer before and after gastrectomy显示文摘AIM: To investigate plasma ghrelin, gastrin and growth hormone secretagogue receptor (GHS-R) expression in advanced gastric cancer (GC) before and after resection. METHODS: Seventy subjects in whom endoscopy of the upper gastrointestinal tract was performed in the Department of General Surgery at Cracow University during the past decade: (1) 25 patients with GC associated with Helicobacter pylori (H. pylori) infection; (2) 10 patients with GC 4-5 years after (total or subtotal) gastrectomy; (3) 25 healthy H. pylori-negative controls, matched by age and BMI to the above two groups; and (4) 10 GC patients 4-5 years after total gastrectomy. Ghrelin and gastrin plasma concentrations were measured by specific radioimmunoassay under fasting conditions and postprandially at 60 and 90 min after ingestion of a mixed meal. GHS-R expression was examined in biopsy samples from intact healthy mucosa and GC tissue using semi-quantitative reverse transcription-polymerase chain reaction. RESULTS: In healthy controls, fasting plasma ghrelin levels were significantly elevated and declined markedly at 60 and 90 min after a mixed meal. The concomitant enhanced ghrelin, GHS-R and gastrin expression in GC tissue over that recorded in intact mucosa, and the marked rise in plasma gastrin in these subjects under fasting conditions indicate the role of these hormonal factors in GC formation. Fasting plasma levels and postprandial response of ghrelin and gastrin appear to be inversely correlated in healthy subjects. Feeding in the controls resulted in a significant fall in plasma ghrelin with a subsequent rise in plasma gastrin, but in H. pylori-positive GC patients submitted to total or distal gastrectomy, feeding failed to affect significantly the fall in plasma ghrelin that was recorded in these patients before surgery. Fasting ghrelin concentrations were significantly lower in patients 4-5 years after total gastrectomy compared to those in healthy controls and to these in GC patients before surgery. CONCLUSION: Elevated plasma gastrin and suppression of fasting ghrelin in patients with GC suggest the existence of a close relationship between these two hormones in gastric carcinogenesis. | Anna Zub-Pokrowiecka Kazimierz Rembiasz Peter C Konturek Andrzej Budzyński Stanisaw J Konturek Marek Winiarski Wadysaw Bielański | 2011 | World Journal of Gastroenterology2011，17，4： | 7 |
| 2 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 3 | Next generation patient-derived prostate cancer xenograft models显示文摘对为前列腺癌症的更有效的治疗学的途径有批评需要。然而,在这个区域的研究被缺乏严重妨碍了临床上相关,在疾病的 vivo 模型试验性。这评论特别地基于 patients’ 的 subrenal 囊 grafting 集中于前列腺癌症异种皮移植模型的发展;进 nonobese 糖尿病 / 严重的肿瘤组织联合了 immunodeficient (NOD/SCID ) 老鼠。这种技术允许可移植的、导出病人的癌症织物异种皮移植线的成功的开发从不仅好攻击变形,而且从局部性的前列腺癌症纸巾。异种皮移植被发现了保留原来的恶意的关键生物性质,包括组织病理学说、分子的特征,肿瘤异质,对雄激素脱离的反应和变形能力。因此,他们是高度临床上相关并且在细胞、分子的层次,为个性化的癌症治疗屏蔽的药和现出症状之前的潜的药为前列腺癌症前进的研究提供珍贵工具测试的功效;特别当模型的一块面板习惯于盖子时许多疾病。这些异种皮移植模型能因此被看作前列腺癌症的下一代的模型。 | Dong Lin Hui Xue Yuwei Wang Rebecca Wu Akira Watahiki Xin Dong Hongwei Cheng Alexander W Wyatt Colin C Collins Peter W Gout Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，3： | 4 |
| 4 | 人体-座椅接触面测量参数的研究初探显示文摘文中介绍了一种集力、温度和湿度传感器信息的座椅舒适度检测系统。传感器的布放采用已发表文章中所介绍的布放方式:温度和湿度传感器分别放置在左、右腿和尾臀骨下方;4个力传感器分别放在左、右腿和左、右坐骨结节的下方。在进行人体实验前,对力、温度和湿度传感器的输出一致性进行了测试。测量数据显示:温度传感器标准方差为±0.2℃;湿度传感器标准方差为±0.3%,压力传感器标准方差为±0.09 V(其中加载负荷5 kg~15 kg,力传感器输出电压的变化为3.67~4.31 V),这表明所有的传感器具有一致的输出特性。在三天内,共有10人/次利用该检测系统对3种坐垫(泡沫、木质和压模坐垫)的舒适度进行了评估。为了避免次序效应对测量结果的影响,整个实验采用了拉丁方设计方法。通过将坐姿调整时间、最大温度和平均相对湿度与舒适度主观评测问卷进行对比分析,结果表明传感器的原始数据和相关参数的变化与人对座椅舒适度的主观评价之间存在一定的联系。 | 刘卓夫 罗中明 Vincenzo Cascioli Louise Mazzeo Andrewl Heusch Peter W M^c Carthy | 2011 | 仪表技术与传感器2011，，1： | 3 |
| 5 | Variations in Wool Growth with Nutrient Supply in Northern China显示文摘Field studies on essessment of nutritional status of the grazing sheep were carried out in each of the three major grassland regions, the eastern Inner Mongolia and beyond grassland, the Inner Mongolia - Ningxia - Gansu grassland and the Xinjiang grassland, in northern China. The results obtained showed that the wool production of fine wool sheep in these regions varied between regions and seasons, with similar seasonal patterns in all regions and that reducing the seasonal variations in nutrient supply would enhance wool production substantially. Nutritional limitations to wool growth of the grazing sheep in these regions were suggested, those were: the shortage of protein supply in winter and early spring; the poor quality of much of the pasture and the hay used as supplements, the low energy intake during winter which probably necessitated the use of body stores to maintain body temperature. | D X Lu,Iner(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)Z C Feng,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)H R Wang,(Mongolia Academy of Animal Sciences.Hohhot City.Inner Mongolia Autgolia Autonmous Region.PRC)R Z Yang,(Xinjiang Institute of Animal Science.Xinjiang Academy of Animal Science.Yiu Hou Road.Urumqi.Xinjiang Uygur Autonomous Region PRC)C T Ma,(Chinese Academy of Agricultural Sciences.Lanzhou.Gansu.PRC)D B Purser,(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)J R Lindsay(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014)D W Peter(CSIRO Division of Animal Production.Laboratory for Rural Research.Private Bag.P.O.Wembley.Western Australia 6014) | 1997 | 畜牧与饲料科学1997，22，S1： | 3 |
| 6 | Prostate cancer metastasis-driving genes: hurdles and potential approaches in their identification显示文摘变形前列腺癌症当前是医不好的。转移被认为在 nonmetastatic 前列腺癌症织物从变化导致特定的驾驶转移的基因的表示,导致设置了在运动的变形过程的激活的下游的基因的串联。如此的基因能潜在地为疾病的改进管理用作有效治疗学的目标。他们能被基因表示侧面的比较分析识别导出病人变形并且指出基因出现的 nonmetastatic 前列腺癌症纸巾改变了表示,由决定如此的基因的 silencing 是否能导致变形性质的抑制列在后面。在这条途径遇到的各种各样的障碍被讨论,包括(i) 对的需要临床上相关, nonmetastatic 和变形前列腺癌症纸巾象 patients’ 的异种皮移植那样;前列腺癌症经由 subrenal 囊 grafting 技术发展了并且(ii ) 在为鉴定的当前可得到的方法论的限制掌握规章的基因。 | Yan Ting Chiang Peter W Gout Colin C Collins Yuzhuo Wang | 2014 | Asian Journal of Andrology2014，16，4： | 2 |
| 7 | Ischemic preconditioning inhibits development of edematous cerulein-induced pancreatitis: Involvement of cyclooxygenases and heat shock protein 70显示文摘AIM: To determine whether ischemic preconditioning (IP)affects the development of edematous cerulein-induced pancreatitis and to assess the role of cyclooxygenase-1 (COX-1), COX-2, and heat shock protein 70 (HSP 70) in this process.METHODS: In male Wistar rats, IP was performed by damping of celiac artery (twice for 5 min at 5-min intervals).Thirty minutes after IP or sham operation, acute pancreatitis was induced by cerulein. Activity of COX-1 or COX-2 was inhibited by resveratrol or rofecoxib, respectively (10 mg/kg).RESULTS: IP significantly reduced pancreatic damage in cerulein-induced pancreatitis as demonstrated by the improvement of pancreas histology, reduction in serum lipase and poly-C ribonuclease activity, and serum concentration of pro-inflammatory interleukin (IL)-1β.Also, IP attenuated the pancreatitis-evoked fall in pancreatic blood flow and pancreatic DNA synthesis.Serum level of anti-inflammatory IL-10 was not affected by IP. Cerulein-induced pancreatitis and IP increased the content of HSP 70 in the pancreas. Maximal increase in HSP 70 was observed when IP was combined with cerulein-induced pancreatitis. Inhibition of COXs, especially COX-2, reduced the protective effect of IP in edematous pancreatitis.CONCLUSION: Our results indicate that IP reduces pancreatic damage in cerulein-induced pancreatitis and this effect, at least in part, depends on the activity of COXs and pancreatic production of HSP 70. | Zygmunt Warzecha Artur Dembinski Piotr Ceranowicz Stanislaw J Konturek Marcin Dembinski Wieslaw W Pawlik Romana Tomaszewska Jerzy Stachura Beata Kusnierz-Cabala Jerzy W Naskalski Peter C Konturek | 2005 | World Journal of Gastroenterology2005，11，38： | 2 |
| 8 | Modulation of β-lactam resistance in Staphylococcus aureus by catechins and gallates显示文摘 | Paul D Stapleton Saroj Shah James C Anderson Yukihiko Hara Jeremy M.T Hamilton-Miller Peter W Taylor | 2004 | International Journal of Antimicrobial Agents2004，，5： | 2 |
| 9 | The white spot syndrome virus DNA genome sequence显示文摘 | Van Huten M C W Witteveldt J Peters S | 2001 | Virology2001，286，： | 1 |
| 10 | Surface pH measurements during nickel electrodeposition 显示文摘 | JI J COOPER W C DREISINGER D B PETERS E | 1995 | Journal of Applied Electrochemistry1995，25，7： | 1 |
| 11 | Influence of microstruc- ture on oxidation behaviour of near - α titanium alloys 显示文摘 | Leyens C Peters M Kaysser W A | 1996 | Materials Science and Technogy1996，12，3： | 1 |
| 12 | EB-PVD thermal barrier coatings for aeroengines and gas turbines显示文摘 | PETERS M LEYENS C CHULZ U KAYSSER W A | 2001 | Advanced Engineering Materials2001，3，4： | 1 |
| 13 | Analyses of free prostate-specific antigen (PSA) after chemical release from the complex with alpha ( 1 )-antichymotrypsin (PSA-ACT) 显示文摘 | Peter J Unverzagt C Hoesel W | 2000 | Clin Chem2000，46，4： | 1 |
| 14 | A recombinant fowlpox virus that expresses the VP2 antigen of infectious bursal disease virus induces protection against mortality caused by the virus显示文摘 | BAYLISS C D PETERS R W COOK J K A | 1991 | Arch Virol1991，120，： | 1 |
| 15 | A single copy of virus- derived transgene encoding hairpin RNA gives immunity to barley yellow dwarf virus显示文摘 | Wang M B David C A Peter M W | 2000 | Molecular plant pathology2000，1，6： | 1 |
| 16 | An introduction to Ebola : the virus and the disease显示文摘 | Peters C J Le-Duc J W | 1999 | J Infect Dis1999，179，1： | 1 |
| 17 | Intermetallic Ti-Al coatings for protection of titanium alloys:oxidation and mechanical behavior 显示文摘 | Leyens C Peters M Kaysser W A | 1997 | Surface and Coatings Technology1997，95，： | 1 |
| 18 | Preparation of nitramine-nitrates by ring-opening nitration of aziridines by dinitrogen pentoxide(N2O5) 显示文摘 | Golding Peter Ross W Millar Norman C Paul | 1993 | Tetrahedron1993，49，32： | 1 |
| 19 | Multiplexing of fibre Bragg grating sensors using subcarrire intensity modulation显示文摘 | Chan Peter K C Jin W Demokan M S | 1999 | Optics & Laser Teclmology1999，31，： | 1 |
| 20 | Antibody response in mice inoculated with DNA expressing foot-and-mouth disease virus capsid proteins显示文摘 | Chinsangaram J Beard C Peter W | 1998 | J Virol1998，72，5： | 1 |
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