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| 1 | Aspirin responsive platelet thrombophilia in essential thrombocythemia and polycythemia vera显示文摘Essential thrombocythemia(ET) and polycythemia vera(PV) frequently present with erythromelalgia and acrocyanotic complications, migraine-like microvascular cerebral and ocular transient ischemic attacks(MIAs) and/or acute coronary disease. The spectrum of MIAs in ET range from poorly localized symptoms of transient unsteadiness, dysarthria and scintillating scotoma to focal symptoms of transient monocular blindness, transient mono- or hemiparesis or both. The attacks all have a sudden onset, occur sequentially rather than simultaneously, last for a few seconds to several minutes and are usually associated with a dull, pulsatile or migraine-like headache. Increased hematocrit and blood viscosity in PV patients aggravate the microvascular ischemic syndrome of thrombocythemia to major arterial and venous thrombotic complications. Phlebotomy to correct hematocrit to normal in PV significantly reduces major arterial and venous thrombotic complications, but fails to prevent the platelet-mediated erythromelalgia and MIAs. Complete long-term relief of the erythromelalgic microvascular disturbances, MIAs and major thrombosis in ET and PV patients can be obtained with low dose aspirin and platelet reduction to normal, but not with anticoagulation. Skin punch biopsies from the erythromelalgic area show fibromuscular intimal proliferation of arterioles complicated by occlusive plateletrich thrombi leading to acrocyanotic ischemia. Symptomatic ET patients with erythromelalgic microvascular disturbances have shortened platelet survival, increased platelet activation markers β-thromboglobulin(β-TG), platelet factor 4(PF4) and thrombomoduline(TM), increased urinary thromboxane B2(TXB2) excretion, and no activation of the coagulation markers thrombin fragments F1+2 and fibrin degradation products. Inhibition of platelet cyclooxygenase(COX1) by aspirin is followed by the disappearance and no recurrence of microvascular disturbances, increase in platelet number, correction of the shortened platelet survival times to normal, and reduction of increased plasma levels of β-TG, PF4, TM and urinary TXB2 excretion to normal. These results indicate that platelet-mediated fibromuscular intimal proliferation and platelet-rich thrombi in the peripheral, cerebral and coronary end-arterial microvasculature are responsible for the erythromelalgic ischemic complica-tions, MIAs and splanchnic vein thrombosis. Baseline platelet P-selectin levels and arachidonic acid induced COX1 mediated platelet activation showed a highly significant increase of platelet P-selectin expression(not seen in ADP and collagen stimulated platelets), which was significantly higher in JAK2V617 F mutated compared to JAK2 wild type ET. | Jan Jacques Michiels Fibo WJ Ten Kate Peter J Koudstaal Perry JJ Van Genderen | 2013 | World Journal of Hematology2013，2，2： | 4 |
| 2 | Eradication of Helicobacter pylori be 7-day triple-therapy regimens combining pantoprazole with clarithromycin,metronidazole,or amoxicinllin in patients with peptic ulcer disease:Results of two double-blind,randomized studies显示文摘 | Bochenek WJ Peters S Praga PD | 2003 | Heloicobacter2003，8，： | 1 |
| 3 | Expresion and secretion fo IL-2 receptor in trauma patients 显示文摘 | Teodoreczyk-lngeyarn JA Mefitehie DI Peters WJ | 1990 | Ann Surery1990，212，： | 1 |
| 4 | Leukotrienes显示文摘 | Peters - Golden M Henderson WJ | 2007 | N Engl J Med2007，357，18： | 1 |
| 5 | A new noninvasive approach in breast cancer therapy using Magnetic Resonance Imaging-guided fo- cused ultrasound surgery 显示文摘 | Peter EH Juergen WJ Ralf R | 2001 | Cancer Research2001，61，： | 1 |
| 6 | Voriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever显示文摘 | Peter P Drew WJ | 2002 | Eng J Med2002，346，4： | 1 |
| 7 | Selective posterior rhizotomy:a long-term follow-up study显示文摘 | Arens LJ Peacock WJ Peter J | 1989 | Childs Nerv Syst1989，5，3： | 1 |
| 8 | Keratin immunoreactivity in melanoma of soft ports(clear cell arcana)显示文摘 | Mooi WJ Deenik W Peter JL | 1995 | Histopathology1995，27，： | 1 |
| 9 | Properties of a collagenolytic enzyme from Bipalium kewense 显示文摘 | Landsperger WJ Peters EH Dresden MH | 1981 | Biochim Biophys Acta1981，661，2： | 1 |
| 10 | Vioriconazole compared with liposomal amphotericin B for empirical antifungal therapy in patients with neutropenia and persistent fever显示文摘 | Peter P Drew WJ | 2002 | Eng J Med2002，346，4： | 1 |
| 11 | Bacterial vaginosis is not important in the etiology of cervical neoplasia:a survey on women with dyskaryotic smears 显示文摘 | Peters N Van Leeuwen AM Pieters WJ | 1995 | Sex Transm Dis1995，22，： | 1 |
| 12 | Prevention of acute thromboisis using heparin- coated stents 显示文摘 | Van der Giessen WJ Peter AH Heleen MM | 1994 | Circulation1994，90，4： | 1 |
| 13 | et al,Bronchial omentopexy in canine lung transplantation显示文摘 | Lima O Goldberg M Peters WJ | 1982 | J Throrac Cardiovasc Surg1982，83，： | 1 |
| 14 | Nipah virus: a recently emergent deadly paramyxovirus 显示文摘 | Chua KB Bellini WJ Rota PA Harcourt BH Tamin A Lam SK Ksiazek TG RoUin PE Zaki SR Shieh W Goldsmith CS Gubler DJ Roehrig JT Eaton B Gould AR Olson J Field H Daniels P Ling AE Peters CA Anderson IJ Mahy BW | 2000 | Science2000，288，5470： | 1 |
| 15 | Eradication of Helicobacter pylori by 7-day triple-therapy regimens combining pantoprazole with clarithromycin,metronidazole,or amoxicillin in patients with peptic ulcer disease:results of two double-blind,randomized studies显示文摘 | Bochenek WJ Peters S Fraga PD | 2003 | Helicobacter2003，8，2： | 1 |
| 16 | Eradication of Helicobacter pylory by 7-day triple-therapy regimens combining pantoprazole with larithromycin,metronidazole,or amoxicillin in patient with peptic ulcer disease,results of two ouble-blind,randomized sdudies显示文摘 | Bochenek WJ Peters S Fraga PD | 2003 | Helicobacter2003，8，： | 1 |
| 17 | The development and empirical testing of extended input - output price models显示文摘 | Fatemeh Bazzazan Peter WJ Batey | 2003 | Economic Systems Research2003，15，1： | 1 |
| 18 | Risk Perception and the Economic Crisis : A Longitudinal Study of the Traj- ectory of Perceived Risk 显示文摘 | Burns WJ Peters E Slovic P | 2012 | Risk Analysis2012，32，4： | 1 |
| 19 | Pulmonary Hypertensive Medical Therapy in Chronic Thromboembolic Pulmonary Hypertension Be- fore Pulmonary Thromboendarterectomy 显示文摘 | Kurt WJ Kim MK Peter FF | 2009 | Circulation2009，120，： | 1 |
| 20 | Protection of normal tissues from the cytotoxic effects of chemotherapy and radiation by amifostine: preclinical aspects显示文摘 | Van der vijgh WJ Peters GJ | 1994 | Semin oncol1994，2115，111： | 1 |
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