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| 1 | Can tranexamic acid change preoperative anemia management during total joint arthroplasty?显示文摘AIM: To investigate the postoperative transfusion and complication rates of anemic and nonanemic total joint arthroplasty patients given tranexamic acid(TXA).METHODS: A cross-sectional prospective study was conducted of primary hip and knee arthroplasty cases performed from 11/2012 to 6/2014. Exclusion criteria included revision arthroplasty, bilateral arthroplasty, acute arthroplasty after fracture, and contraindication to TXA. Patients were screened prior to surgery, with anemia was defined as hemoglobin of less than 12 g/d L for females and of less than 13 g/d L for males. Patients were divided into four different groups, based on the type of arthroplasty(total hip or total knee) and hemoglobin status(anemic or nonanemic). Intraoperatively, all patients received 2 g of intravenous TXA during surgery. Postoperatively, allogeneic blood transfusion(ABT) was directed by both clinical symptomsand relative hemoglobin change. Complications were recorded within the first two weeks after surgery and included thromboembolism, infection, and wound breakdown. The differences in transfusion and complication rates, as well as the relative hemoglobin change, were compared between anemic and nonanemic groups.RESULTS: A total of 232 patients undergoing primary joint arthroplasty were included in the study. For the total hip arthroplasty cohort, 21%(18/84) of patients presented with preoperative anemia. Two patients in the anemic group and two patients in the nonanemic group needed ABTs; this was not significantly different(P = 0.20). One patient in the anemic group presented with a deep venous thromboembolism while no patients in the nonanemic group had an acute complication; this was not significantly different(P = 0.21). For nonanemic patients, the average change in hemoglobin was 2.73 ± 1.17 g/d L. For anemic patients, the average change in hemoglobin was 2.28 ± 0.96 g/d L. Between the two groups, the hemoglobin difference of 0.45 g/d L was not significant(P = 0.13). For the total knee arthroplasty cohort, 18%(26/148) of patients presented with preoperative anemia. No patients in either group required a blood transfusion or had an acute postoperative complication. For nonanemic patients, the average change in hemoglobin was 1.85 ± 0.79 g/d L. For anemic patients, the average change in hemoglobin was 1.09 ± 0.58 g/d L. Between the two groups, the hemoglobin difference of 0.76 g/d L was significant(P < 0.001). CONCLUSION: TXA administration results in low transfusion and complication rates and may be a useful adjunct for TJA patients with preoperative anemia. | Duy L Phan Joseph B Rinehart Ran Schwarzkopf | 2015 | World Journal of Orthopedics2015,6,7: | 5 |
| 2 | High-throughput synthesis of zeolitic imidazolate frameworks and application to CO2 capture显示文摘 | Banerjee R Phan A Wang B | 2008 | Science2008,319,5865: | 1 |
| 3 | Role of hemophagocytic histiocytosis in the etiology of thrombocytopenia in patients with sepsis syndrome or septic shock 显示文摘 | Ste'phan F Thiolie're B Verdy E | 1997 | Clin Infect Dis1997,25,5: | 1 |
| 4 | Phase equilibria and thermodynamics of the Fe-A1-C system: Critical evaluation, experiment and thermodynamic optimization显示文摘 | PHAN A T PAEK M K KANG Y B | 2014 | Acta Materialia2014,79,: | 1 |
| 5 | High-throughput synthesis of zeolitic imidazolate frameworks and applica- tion to CO2 capture 显示文摘 | Banerjee R Phan A Wang B | 2008 | Science2008,319,: | 1 |
| 6 | The myofibroblast:one function,multiple origins显示文摘 | Hinz B Phan SH Thannickal VJ | | 0,,06: | 1 |
| 7 | The endothelial cell receptor GRP78 is required for mucormycosis pathogenesis in diabetic mice显示文摘 | LIU M SPELLBERG B PHAN Q T | 2010 | J Clin Invest2010,120,6: | 1 |
| 8 | Production of a monoclonal anti- body against the hRRM2 subunit of ribonucleotide reductase and immunohistochemistry study of human cancer tissues显示文摘 | Zhou B Phan V Liu X | 2006 | Hybri- doma (Larchmt)2006,25,5: | 1 |
| 9 | Chemotactic factors and renal inflammation 显示文摘 | Rovin B H Phan L T | 1998 | Am J Kidney Dis1998,31,6: | 1 |
| 10 | Natural occurrence of higher thiadiamondoids and diamondoidthiols in a deep petroleum reservoir in the Mobile Bay gas field 显示文摘 | Wei Z B Mankiewicz P Waiters C Qian K N Phan N T Madincea M E Nguyen P T H | 2011 | Org Geochem2011,42,2: | 1 |
| 11 | Evaluation of the production potential of bio-oil from Vietnamese biomass resources by fast pyrolysis 显示文摘 | Phan B M Q Duong L T Nguyen V D | 2014 | Biomass and Bioenergy2014,62,: | 1 |
| 12 | Dietary compounds inhibit proliferation and contraction of keloid and hypertrophic scar-derived fibroblasts in vitro: therapeutic implication for excessive scarring显示文摘 | PHAN T T SUN L BAY B H | 2003 | J Trauma2003,54,6: | 1 |
| 13 | High-throughput synthesis of zeolitic imidazolate frameworks and application to CO2 capture 显示文摘 | Banerjee R Phan A Wang B | 2008 | Science2008,319,5865: | 1 |
| 14 | The myofibro-blast:One function,multiple origins显示文摘 | Hinz B Phan SH Thannickal VJ | 2007 | Am J Pathol2007,170,6: | 1 |
| 15 | Dibenzocyclooctadiene lignans and lanostane derivatives from the roots of Kadsura coccinea and their protective effects on primary rat hepatocyte injury induced by t - butyl hydroperoxide显示文摘 | NINH K B BUI V T PHAN V K | | 0,,11: | 1 |
| 16 | Active XML (AXML)research:Survey on the representation, system architecture, data exchange mechanism and query evaluation显示文摘 | Phan B V Pardede E | 2014 | Journal of Network and Computer Applications2014,37,: | 1 |
| 17 | Mathematical modelling of slow pyrolysis of segregatedsolid wastes in a packed-bed pyrolyser显示文摘 | YANG Y B PHAN A N RYU C | 2007 | Fuel2007,86,12: | 1 |
| 18 | Association of high - density lip-oprotein levels and carotid atherosclerotic plaque characteristics by mag-netic resonance imaging 显示文摘 | Phan BA Chu B Polissar N | 2007 | Int J Cardiovasc Imaging2007,23,3: | 1 |
| 19 | High-Throughput synthesis of zeolitic imidazolate frameworks and application to CO2 capture显示文摘 | Banerjee R Phan A Wang B | | 0,,5865: | 1 |
| 20 | Recent develop- ments in myofibroblast biology: paradigms for connective tissue remodeling 显示文摘 | Hinz B Phan SH Thannickal VJ | 2012 | Am J Pathol2012,180,: | 1 |