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| 1 | Innate and adaptive immune responses in male and female reproductive tracts in homeostasis and following HIV infection显示文摘男、女的繁殖的道是有多样的功能的要求的复杂微型环境。当同时对潜在的病原体授与保护时,在繁殖的道的免疫系统举办为胎儿的 allograft 提供保护的环境的费力的任务。因此,它发展了改编的一个唯一的集合,首先在性荷尔蒙的影响下面,它从另外的 mucosal 地点使它不同。这里,我们讨论在男性和女繁殖的道是在场的免疫系统的各种各样的部件,包括在 homeostatic 条件下面的天生的可溶的因素和房间和体液、调停房间的适应免疫。我们考察在从全身的豁免展出区分并且讨论这些特征怎么被性荷尔蒙影响的男、女的繁殖的道显示出唯一的 phenotypic 和有免疫力的房间和回答的功能的特征的证据。我们也在跟随 HIV-1 感染的繁殖的道,性荷尔蒙和有免疫力的回答之中检验相互作用。男、女的繁殖的道的唯一的特征的改进理解将提供卓见进为性播送的感染的预防改进不孕的免疫学的原因和预防干预的设计的临床的处理。 | Philip V Nguyen Jessica K Kafka Victor H Ferreira Kristy Roth Charu Kaushic | 2014 | Cellular & Molecular Immunology2014，11，5： | 7 |
| 2 | Appropriateness of systemic treatments in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors显示文摘AIM:To evaluate systemic treatment choices in unresectable metastatic well-differentiated pancreatic neuroendocrine tumors(PNETs)and provide consensus treatment recommendations.METHODS:Systemic treatment options for pancreatic neuroendocrine tumors have expanded in recent years to include somatostatin analogs,angiogenesis inhibitors,inhibitors of mammalian target of rapamycinand cytotoxic agents.At this time,there is little data to guide treatment selection and sequence.We therefore assembled a panel of expert physicians to evaluate systemic treatment choices and provide consensus treatment recommendations.Treatment appropriateness ratings were collected using the RAND/UCLA modified Delphi process.After studying the literature,a multidisciplinary panel of 10 physicians assessed the appropriateness of various medical treatment scenarios on a 1-9 scale.Ratings were done both before and after an extended discussion of the evidence.Quantitative measurements of agreement were made and consensus statements developed from the second round ratings.RESULTS:Specialties represented were medical and surgical oncology,interventional radiology,and gastroenterology.Panelists had practiced for a mean of15.5 years(range:6-33).Among 202 rated scenarios,disagreement decreased from 13.2%(26 scenarios)before the face-to-face discussion of evidence to 1%(2)after.In the final ratings,46.5%(94 scenarios)were rated inappropriate,21.8%(44)were uncertain,and30.7%(62)were appropriate.Consensus statements from the scenarios included:(1)it is appropriate to use somatostatin analogs as first line therapy in patients with hormonally functional tumors and may be appropriate in patients who are asymptomatic;(2)it is appropriate to use everolimus,sunitinib,or cytotoxic chemotherapy therapy as first line therapy in patients with symptomatic or progressive tumors;and(3)beyond first line,these same agents can be used.In patients with uncontrolled secretory symptoms,octreotide LAR doses can be titrated up to 60 mg every4 wk or up to 40 mg every 3 or 4 wk.CONCLUSION:Using the Delphi process allowed physician experts to systematically obtain a consensus on the appropriateness of a variety of medical therapies in patients with PNETs. | Jonathan R Strosberg George A Fisher Al B Benson Lowell B Anthony Bulent Arslan John F Gibbs Edward Greeno Renuka V Iyer Michelle K Kim William J Maples Philip A Philip Edward M Wolin Dasha Cherepanov Michael S Broder | 2015 | World Journal of Gastroenterology2015，21，8： | 2 |
| 3 | Prolonged remission from eltrombopag in chronic refractory idiopathic thrombocytopenic purpura显示文摘 | Noronha V Philip SD Joshi A | 2012 | Int J Hematol2012，96，3： | 1 |
| 4 | Stability of Networked Control Systems显示文摘 | Zhang W Branicky M S V Philips S M | 2001 | IEEE Control Systems Magazine2001，21，2： | 1 |
| 5 | Clonal propagation of Vanilla planifolia (Sslisb) Ames using tissue culture显示文摘 | Philip V J Nainar A Z | 1986 | J Plant Physiol1986，122，： | 1 |
| 6 | High-performance high-speed steels by design显示文摘 | Steven G Nehrenberg A E Philip T V | 1964 | Trans ASM1964，57，64： | 1 |
| 7 | End-stage renal disease and economic incentives:The international study of health care organization and fi- nancing显示文摘 | AviDor Mark V Pauly Margaret A Eichleay Philip J Held | 2007 | International Journal of Health Care Finance and Economics2007，，2： | 1 |
| 8 | Image scrambling withoutbandwidth expansion显示文摘 | Ville D V D Philips W Walle R V | 2004 | IEEE Trans Circuits Syst Video Technol2004，14，6： | 1 |
| 9 | Barberb GSTM1 copy number and lung cancer risk显示文摘 | Philip A.J Crosbiea b c Philip V | | 0，，01： | 1 |
| 10 | Asymptotics for linear processes显示文摘 | Philips P C B Solo V | 1992 | Ann Statist1992，20，： | 1 |
| 11 | Detection of genomic amplification of the human te|omerase gene (TERC) in cytologic specimens as a genetic test for the diagnosis of cervicaldysplasia显示文摘 | Hevelmeyer Haddad K J anz V Philip E | 2003 | Am J Pathol2003，163，4： | 1 |
| 12 | Recursive temporal denoising and motion estimation in video显示文摘 | ZLOKOLICA V PIITIRICA A PHILIPS W | 2004 | IEEE2004，3，： | 1 |
| 13 | Effects of Loading Frequency and Stress Reversal on Fatigue Life of Plain Concrete显示文摘 | Zhang B Philips D V Wu K | 1996 | Magazine of Concrete Research1996，48，177： | 1 |
| 14 | The antibiotic activity of the lac- toperoxidase-thiocyanate-hydrogen peroxide system in the calf ab- sorption of nutrients in the pig显示文摘 | Reiter A A Marshal V M Philips S M | 1980 | Res Vet Sci1980，28，： | 1 |
| 15 | The growth of Mg(OH)2 crystals from MgCl2 and Ca(OH)2 in a brine environment显示文摘 | Philips V A Kolbe J L Opperharser H | 1997 | Journal of Crystal Growth1997，41，： | 1 |
| 16 | Investigation of the attachment of Thiobacillus ferrooxidans to mineral sulfides using scanning elctron microscopy analysis显示文摘 | SAMPSON M L PHILIPS C V BALL A S | 2000 | Minerals Engineering2000，13，： | 1 |
| 17 | Hybrid block replacementheterogeneous component lives 显示文摘 | Philip A S Cristiano A V C | 2010 | European Journal ofOperational Research2010，206，2： | 1 |
| 18 | DNA replication regulation protein Mcm7 as a marker of proliferation in prostate cancer显示文摘 | Padmanabhan V Callas P Philips G | 2004 | J Clin Pathol2004，57，10： | 1 |
| 19 | Separation of functionalities in pyrolytic tar by gel permeation chromatography-gas chromatography显示文摘 | SHEU Y-H E PHILIP C V ANTHONY R G | 1984 | J Chromatogr Sci1984，22，1： | 1 |
| 20 | Development and Application of an Eight-Step Global Mechanism for CFD and CRN Simulations of Lean-Premixed Combustors 显示文摘 | Igor V Novosselov Philip C Mahe | 2008 | Journal of Engineering for Gas Turbines and Power2008，130，： | 1 |
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