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| 1 | Retrograde-viewing device improves adenoma detection rate in colonoscopies for surveillance and diagnostic workup显示文摘AIM:To determine which patients might benefit most from retrograde viewing during colonoscopy through subset analysis of randomized,controlled trial data.METHODS:The Third Eye Retroscope Randomized Clinical Evaluation(TERRACE) was a randomized,controlled,multicenter trial designed to evaluate the efficacy of a retrograde-viewing auxiliary imaging device that is used during colonoscopy to provide a second video image which allows viewing of areas on the proximal aspect of haustral folds and flexures that are difficult to see with the colonoscope's forward view.We performed a post-hoc analysis of the TERRACE data to determine whether certain subsets of the patient population would gain more benefit than others from use of the device.Subjects were patients scheduled for colonoscopy for screening,surveillance or diagnostic workup,and each underwent same-day tandem examinations with standard colonoscopy(SC) and Third Eye colonoscopy(TEC),randomized to SC followed by TEC or vice versa.RESULTS:Indication for colonoscopy was screening in 176/345 subjects(51.0%),surveillance after previous polypectomy in 87(25.2%) and diagnostic workup in 82(23.8%).In 4 subjects no indication was specified.Previously reported overall results had shown a net additional adenoma detection rate(ADR) with TEC of 23.2% compared to SC.Relative risk(RR) of missing adenomas with SC vs TEC as the initial procedure was 1.92(P = 0.029).Post-hoc subset analysis shows additional ADRs for TEC compared to SC were 4.4% for screening,35.7% for surveillance,55.4% for diagnostic and 40.7% for surveillance and diagnostic combined.The RR of missing adenomas with SC vs TEC was 1.11(P = 0.815) for screening,3.15(P = 0.014) for surveillance,8.64(P = 0.039) for diagnostic and 3.34(P = 0.003) for surveillance and diagnostic combined.Although a multivariate Poisson regression suggested gender as a possibly significant factor,subset analysis showed that the difference between genders was not statistically significant.Age,bowel prep quality and withdrawal time did not significantly affect the RR of missing adenomas with SC vs TEC.Mean sizes of adenomas detected with TEC and SC were similar at 0.59 cm and 0.56 cm,respectively(P = NS).CONCLUSION:TEC allows detection of significantly more adenomas compared to SC in patients undergoing surveillance or diagnostic workup,but not in screening patients(ClinicalTrials.gov Identifier:NCT01044732). | Peter D Siersema Amit Rastogi Anke M Leufkens Paul A Akerman Kassem Azzouzi Richard I Rothstein Frank P Vleggaar Alessandro Repici Giacomo Rando Patrick I Okolo Olivier Dewit Ana Ignjatovic Elizabeth Odstrcil James East Pierre H Deprez Brian P Saunders Anthony N Kalloo Bradley Creel Vikas Singh Anne Marie Lennon Daniel C DeMarco | 2012 | World Journal of Gastroenterology2012，18，26： | 6 |
| 2 | TAT-Gap19通过抑制啮齿动物星形胶质细胞的连接蛋白43半通道发挥抗惊厥作用显示文摘越来越多的证据表明,星形胶质细胞连接蛋白43(Cx43)信号在癫痫中发挥至关重要的作用。但是,由于通过实验方法鉴别Cx43间隙连接通道(GJCs)和半通道(HCs)的技术尚不成熟,导致目前尚无法确定哪个通道在癫痫的发生中发挥更重要的作用。因此,本研究观察TAT-Gap19(Cx模拟肽)是否通过抑制Cx43半通道而非Cx43间隙连接通道影响实验诱导的啮齿动物癫痫发作。急性海马切片小鼠染料摄取实验表明,星形胶质Cx43半通道响应化学惊厥毛果芸香碱的作用而开放,并且可被TAT-Gap19抑制。体内实验中,毛果芸香碱诱导的癫痫发作及相伴随的D-丝氨酸微透析液的增长水平被Cx43半通道的抑制所抑制。此外,TAT-Gap19的抗惊厥作用被外源性D-丝氨酸给药逆转,这表明,抑制Cx43半通道可以通过降低细胞外D-丝氨酸水平来防止癫痫发作。抑制Cx43半通道的抗惊厥特性在电癫痫小鼠模型(如急性6 Hz难治性癫痫发作模型和慢性6 Hz角膜点燃模型)中得到了进一步的证实。总而言之,这些结果表明,Cx43半通道在癫痫发作中可以起到一定作用,并且有成为癫痫治疗中新型用药靶点的潜力。 | Walrave L Pierre A Albertini G Aourz N De Bundel D Van Eeckhaut A Vinken M Giaume C Leybaert L Smolders I 聂昊 | 2018 | 神经损伤与功能重建2018，13，6： | 5 |
| 3 | ACC/AHA guidelines for the management of patients with unstable angina and non–st-segment elevation myocardial infarction显示文摘 | Eugene Braunwald Elliott M Antman John W Beasley Robert M Califf Melvin D Cheitlin Judith S Hochman Robert H Jones Dean Kereiakes Joel Kupersmith Thomas N Levin Carl J Pepine John W Schaeffer Earl E Smith David E Steward Pierre Theroux Raymond J Gibbons J | 2000 | Journal of the American College of Cardiology2000，，3： | 4 |
| 4 | Efficacy of azacitidine compared with that of conventional care regimens in the treatment of higher-risk myelodysplastic syndromes: a randomised, open-label, phase III study显示文摘 | Pierre Fenaux Ghulam J Mufti Eva Hellstrom-Lindberg Valeria Santini Carlo Finelli Aristoteles Giagounidis Robert Schoch Norbert Gattermann Guillermo Sanz Alan List Steven D Gore John F Seymour John M Bennett John Byrd Jay Backstrom Linda Zimmerman David M | 2009 | Lancet Oncology2009，，： | 2 |
| 5 | A high-efficiency CMOS voltage doubler显示文摘 | Pierre F Philippe D Declercq M J | 1998 | IEEE Journal of Solid-State Circuits1998，33，3： | 1 |
| 6 | Complete ana lytic elastic study of a 90°branch connection of a cylinder on a sphere subjected to a bending load显示文摘 | PLANCQ D BERTON M N PIERRE G | 1997 | International Journal o Pressure Vessels and Piping1997，71，1： | 1 |
| 7 | Increased topsoil mineral nutrient concentrations under exotic invasive plants in Belgium显示文摘 | Sonia V Nicolas D Pierre M | 2005 | Plant and soil2005，275，12： | 1 |
| 8 | Isolation of plant DNA:a fast,inexpensive and reliable method显示文摘 | Pierre G Haurence M D | 1992 | Plant Mol Rep1992，10，： | 1 |
| 9 | Initial results in electromechanical mode identification from ambient data显示文摘 | PIERRE J W TRUDNOWSKI D J DONNELLY M K | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 10 | Magnetite nanoparticle dispersions stabilized with triblock copolymers显示文摘 | Harris L A Goff J D Carmichael A Y Riffle J S Harburn J J Pierre T G S Saunders M | 2003 | Chemistry of Materials2003，15，： | 1 |
| 11 | Status after 10 years of operation-overview of UF technology today显示文摘 | J M La(i)né D Vial Pierre Moulart | 2000 | Desalination2000，，131： | 1 |
| 12 | Initial resuits in electromechanical mode identification from ambient data显示文摘 | PIERRE J W TRUDNOWSKI D J DONNELLY M K | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 13 | Initial re-sults in electromechanical mode identification from ambient data显示文摘 | PIERRE J W TRUDNOWSKI D J DONNELLY M K | 1997 | IEEE Trans on Power Systems1997，12，3： | 1 |
| 14 | Safety and feasibility of motexafin gadolinium administration with whole brain radiation therapy and ster- eotactic radiosurgery boost in the treatment of 6 brain metastases: a multi - institutional phase II trim 显示文摘 | Derek R M Pierre C Anne D | 2011 | Journal of Neuro -Oncology2011，105，2： | 1 |
| 15 | Steroid saponins from fenugreek seeds:extraction,purification,and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R P Yves D S Dominique M H | 1995 | Steroids1995，60，10： | 1 |
| 16 | Steroid saponins from fenugreek seeds:extraction,purification and pharmacological investigation on feeding behavior and plasma cholesterol显示文摘 | Pierre R Yves D Dominique M | 1995 | Steroids1995，60，： | 1 |
| 17 | Isolation of plant DNA:A fast,inexpensive,and reliable method显示文摘 | Pierre G Haurence M D | 1992 | Plant Mol Biol Rep1992，，10： | 1 |
| 18 | Calibration of the perfect mixing model to a dry grinding mill 显示文摘 | C Bazin M Pierre D Hodouin | 2005 | Powder technology2005，149，3： | 1 |
| 19 | Aging mechanisms and lifetime of PEFC and DMFC显示文摘 | KNIGHTS S D COLBOW K M PIERRE J S | 2004 | J Power Sources2004，127，： | 1 |
| 20 | Congenital lumbosacral lipomas显示文摘 | Pierre Kahn A Zerah M Renier D | 1997 | Childs Nerv Syst1997，13，： | 1 |
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