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| 1 | Characterization of monocarboxylate transporter activity in hepatocellular carcinoma显示文摘AIM: To assess the immunoexpression of hypoxiarelated markers in samples from cirrhosis and primary and metastatic hepatocellular carcinoma(HCC).METHODS: From a total of 5836 autopsies performed at the Pathology Department- University of Sao Paulo School of Medicine Hospital- from 2003 to 2009, 188 presented primary liver tumors. Immunohistochemical reactivity for monocarboxylate transporters(MCTs)-1, 2 and 4, CD147 and glucose transporter-1(GLUT1)was assessed in necropsies from 80 cases of HCC. Data were stored and analyzed using the IBM SPSS statistical software(version 19, IBM Company, Armonk, NY). All comparisons were examined for statistical significance using Pearson's χ2 test and Fisher's exact test(when n < 5). The threshold for significant P values was established as P < 0.05.RESULTS: Plasma membrane expression of MCT4 and overall expression of GLUT1 showed progressively higher expression from non-neoplastic to primary HCC and to metastases. In contrast, overall expression of MCT2 was progressively decreased from non-neoplastic to primary HCC and to metastases. MCT1(overall and plasma membrane expression), MCT2 and CD147 plasma membrane expression were associated with absence of cirrhosis, while plasma membrane expression of CD147 was also associated with absence of HBV infection. MCT2 overall expression was associated with lower liver weight, absence of metastasis and absence of abdominal dissemination. Additionally, MCT4 plasma membrane positivity was strongly associated with Ki-67 expression. CONCLUSION: MCT4 and GLUT1 appear to play a role in HCC progression, while MCT2 is lost during progression and associated with better prognosis. | Venncio AF Alves Céline Pinheiro Filipa Morais-Santos Aloisio Felipe-Silva Adhemar Longatto-Filho Fátima Baltazar | 2014 | World Journal of Gastroenterology2014，20，33： | 11 |
| 2 | Embolization of splenorenal shunt associated to portal vein thrombosis and hepatic encephalopathy显示文摘Hepatic encephalopathy(HE)is a cognitive disturbance characterized by neuropsychiatric alterations.It occurs in acute and chronic hepatic disease and also in patients with portosystemic shunts.The presence of these portosystemic shunts allows the passage of nitrogenous substances from the intestines through systemic veins without liver depuration.Therefore,the embolization of these shunts has been performed tocontrol HE manifestations,but the presence of portal vein thrombosis is considered a contraindication.In this presentation we show a cirrhotic patient with severe HE and portal vein thrombosis who was submitted to embolization of a large portosystemic shunt.Case report:a 57 years-old cirrhotic patient who had been hospitalized many times for persistent HE and hepatic coma,even without precipitant factors.She had a wide portosystemic shunt and also portal vein thrombosis.The abdominal angiography confirmed the splenorenal shunt and showed other shunts.The larger shunt was embolized through placement of microcoils,and the patient had no recurrence of overt HE.There was a little increase of esophageal and gastric varices,but no endoscopic treatment was needed.Since portosystemic shunts are frequent causes of recurrent HE in cirrhotic patients,portal vein thrombosis should be considered a relative contraindication to perform a shunt embolization.However,in particular cases with many shunts and severe HE,we found that one of these shunts can be safely embolized and this procedure can be sufficient to obtain a good HE recovery.In conclusion,we reported a case of persistent HE due to a wide portosystemic shunt associated with portal vein thrombosis.As the patient had other shunts,she was successfully treated by embolization of the larger shunt. | Letícia de Campos Franzoni Fábio Cardoso de Carvalho Rafael Gomes de Almeida Garzon Fábio da Silva Yamashiro Laís Augusti Lívia Alves Amaral Santos Mariana de Souza Dorna Júlio Pinheiro Baima Talles Bazeia Lima Carlos Antonio Caramori Giovanni Faria Silva Fernando Gomes Romeiro | 2014 | World Journal of Gastroenterology2014，20，42： | 6 |
| 3 | Hereditary diffuse gastric cancer – Pathophysiology and clinical management显示文摘 | Hugo Pinheiro Carla Oliveira Raquel Seruca Fátima Carneiro | 2014 | Best Practice & Research Clinical Gastroenterology2014，，6： | 2 |
| 4 | Photochemical responses and oxidative stress in the clones of Coffea canephora under water deficit conditions显示文摘 | Lima A L S DaMatta F M Pinheiro H A | 2002 | Environmental and Experimental Botany2002，47，23： | 1 |
| 5 | Photochemical responses and oxidative stress in two clones of Coffea canephora under water deficit conditions显示文摘 | LIMA A L S DAMATT F M PINHEIRO H A | 2002 | Environmental and Experimental Botany2002，47，： | 1 |
| 6 | A space vector PWM modulation scheme for back-to-back three-level diode-clamped converters显示文摘 | Grigoletto F B Pinheiro H | 2009 | IEEE Transactions on Power Electronics Conference2009，，： | 1 |
| 7 | Effects of early feed restriction and enzyme supplementation on digestiveenzyme activities in broilers显示文摘 | Pinheiro D F Cruz V C Sartori J R | 2004 | Poultry Science2004，83，： | 1 |
| 8 | The epitaxial growth of Pd electrodeposition on Au(100) studied by LEED and RHEED 显示文摘 | Pinheiro A L N Zei M S Luo M F | 2006 | Surface Science2006，600，： | 1 |
| 9 | Drought tolerance in relation to protection against oxidative stress in clones of Coffea canephora subjected to long-term drought显示文摘 | Pinheiro H A DaMatta F M Chaves A R M | 2004 | Plant Science2004，167，6： | 1 |
| 10 | Drought tolerance in relation to protection against oxidat'ive stress inclones of Cojfea canephora subjected to long-term drought 显示文摘 | PINHEIRO H A DAMATTA F M CHAVES ARM | 2004 | Plant Science2004，167，： | 1 |
| 11 | 限饲和再投喂对不同日龄鸡消化酶促反应的影响显示文摘试验旨在评价限饲和再投喂对两个不同日龄(7和35d)鸡酶活性和胃肠道器官重量的影响,在每种日龄下,鸡被限饲70%(30%自由采食)7d,然后自由采食3d。对照组自由采食10d。对胰腺中糜蛋白酶、胰蛋白酶、淀粉酶、脂肪酶活性和小肠中蔗糖酶、麦芽糖酶的活性进行分析,并且测量了腺胃、肌胃、小肠和大肠的重量。在14d,与对照组相比,限饲组的胰蛋白酶、淀粉酶活性均降低,但在42d,与对照组相比,限饲组蔗糖酶活性降低,表明限饲对酶活性的影响与日龄有关。限饲可以降低完成期(42d)各器官的重量。日龄35~42d的鸡,在再投喂后,器官重量增加,并且达到与对照组一致。在起始期(14d),腺胃和肌胃受限饲的影响很小,在完成期,肌胃也是受影响最小的器官,而小肠时受影响最严重。限饲的所有影响在恢复饲喂3d后被逆转,表明这种改变时快速且可逆的,并且限饲和再投喂与年龄有关。 | Cristiane R A Duarte Maria L M Vicentini P Pinheiro D F | 2014 | 饲料博览2014，0，10： | 1 |
| 12 | Cyclooxygenase- 2 and epidermal growth factor receptor expressions in different histological subtypes of cervical carcinomas显示文摘 | Baltazar F Filho AL Pinheiro C | 2007 | Int I Gynecol Pathol2007，26，3： | 1 |
| 13 | The stereoselective synthesis of nopinone based triazole ketones显示文摘 | Silva Junior R C Ferreira V F Pinheiro S | 2004 | Tetrahedron:Asymmetry2004，15，： | 1 |
| 14 | Biphasic ethylene polymerization with a diimine nickel catalyst显示文摘 | Mauler R S de Souza R F | 2001 | Macromol Rapid Commun2001，22，6： | 1 |
| 15 | Successful liver allograft inflow reconstruction with the right gastroepiploic vein显示文摘Portal vein thrombosis is a common complication in cirrhotic patients. When portal vein thrombectomy is not a suitable option, a large collateral vessel can be used for allograft venous inflow reconstruction. We describe an unusual case of successful portal revascularization using the right gastroepiploic vein. The patient underwent a cadaveric orthotopic liver transplantation with end-to-end anastomosis of the portal vein to the right gastroepiploic vein. Six months after liver transplantation the patient is well with good liver function. The use of the right gastroepiploic vein for allograft venous reconstruction is feasible and safe, with a great advantage of avoiding the need of venous jump graft. | Rafael S Pinheiro Ruy J Cruz Jr Lucas S Nacif Matheus F Vane Luiz AC D'Albuquerque | 2016 | Hepatobiliary & Pancreatic Diseases International2016，15，1： | 1 |
| 16 | Analysis of the molecular evolutionary history of the ascorbate peroxidase gene family: inferences from the rice genome显示文摘 | Teixeira F Benavente L Margis R Pinheiro M | 2004 | Journal of Molecular Evolution2004，59，6： | 1 |
| 17 | E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions显示文摘 | Patrícia Carneiro Maria Sofia Fernandes Joana Figueiredo Joana Caldeira Joana Carvalho Hugo Pinheiro Marina Leite Soraia Melo Patrícia Oliveira Joana Sim?es-Correia Maria José Oliveira Fátima Carneiro Céu Figueiredo Joana Paredes Carla Oliveira Raquel Ser | 2012 | FEBS Letters2012，，18： | 1 |
| 18 | Proteome analysis of secondary somaticembryogenesis in cassava(Manihot esculenta)显示文摘 | Baba A I Nogueira F C S Pinheiro C B | 2008 | Plant Science2008，175，： | 1 |
| 19 | Cell death during sepsis: integration of disintegration in the inflammatory response to overwhelming infection显示文摘 | Pinheiro da Silva F Nizet V | 2009 | Apoptosis2009，14，4： | 1 |
| 20 | Serologic immunoreactivity to Neospora caninurn antigens in dogs determined by indirect immunofluorescence,western blotting and dot-ELISA显示文摘 | Pinheiro A M Costa M F Paule B | 2005 | Vet Parasitol2005，130，12： | 1 |
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