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| 1 | Alcohol binging causes peliosis hepatis during azathioprine therapy in Crohn's disease显示文摘Patients with inflammatory bowel disease have normal life expectancy and, due to modern immunosuppressive therapies, also a normal quality of life. Since mostly young people are affected, their social behaviour suits this environment. Alcohol binging is an increasingly disturbing factor among young people. We describe a patient with Crohn's disease, treated with azathioprine, who developed peliosis hepatis after three epsiodes of alcohol binging. Liver toxicity was not observed previously during the course of the treatment. Azathioprine-induced peliosis hepatis is thought to be idiosyncratic in humans. From animal studies, however, it is clear that hepatic depletion of glutathione leads to azathioprine toxicity to the sinusoidal endothelial cells. Damage of these cells causes peliosis hepatis. Since alcohol binging leads to hepatic glutathione depletion, we conclude that in our patient the episodes of binging have reduced liver gluathione content and therefore this has increased azathioprine toxicity causing peliosis hepatis. The problem of alcohol binging has not yet been addressed in IBD patients undertaking immunosuppressive therapy. This should be reviewed in future considerations regarding patients advice. | Christoph Elsing Joerg Placke Thomas Herrmann | 2007 | World Journal of Gastroenterology2007，13，34： | 3 |
| 2 | Ten-day repeated-exposure inhalation study of dimethyl{ormamide (DMF) in cynomolgus monkeys 显示文摘 | Hurtt ME Mccooey KT Placke ME | 1991 | Toxicol Lett1991，59，： | 1 |
| 3 | Sctuodyg pnrotiotciovl e be- havioural therapy in elderly type 2 diabetes patients with minor de- pression or mild major depression: study protocol of a randomized controlled trial (MIND-DIA) 显示文摘 | Petrak F Hautzinger M Plack K | 2010 | BMC Geriatrics2010，10，： | 1 |
| 4 | Thirteen-week inhalation toxicity of N,N-Dimethylformamide in F344/N rats and B6C3F1 mice显示文摘 | Lynch DW Placke ME Persing RL | 2003 | Toxicol Sci2003，72，： | 1 |
| 5 | Platelet-derived transfor- ming growth factor-beta down-regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity 显示文摘 | Kopp HG Placke T Salih HR | 2009 | Cancer Res2009，69，19： | 1 |
| 6 | Method of determining imidacloprid residues in plant materials显示文摘 | Plack F J and Werber E | 1993 | Pflanzensehutz Nachr Bayer1993，469，2： | 1 |
| 7 | Global distribution of species diversity in vascular plants: towards a world map of phytodiversity显示文摘 | Barthlott W Lauer W Placke A | 1996 | Erdkunde1996，50，4： | 1 |
| 8 | The wolf in sheep’s clothing:Plateletderived'pseudo self'impairs cancer cell'missing self'recognition by NK cells显示文摘 | Placke T Kopph G Salih H R | 2012 | Oncoimmunology2012，1，4： | 1 |
| 9 | Thirteen -week inhalation toxicity of N, N - dimethylformamide in F344/N rats and B6C3F1 mice 显示文摘 | Lynch D W Placke M E Persing R L | 2003 | TOXICO- LOGICAL SCIENCES2003，72，： | 1 |
| 10 | Effects of masker frequency and duration in forward masking:further evidence for the influence of peripheral nonlinearity显示文摘 | Oxenham A J Plack CK | 2000 | Hear Res2000，150，12： | 1 |
| 11 | Inter-- relationship between different psychoacoustic measures assumed to be re- lated to the cochlear active mechanism显示文摘 | Moore BCJ Vickers DA Plack CJ | 1999 | J Acoust Soc Am1999，106，： | 1 |
| 12 | Residue analytical method for the determination of residues of YRC 2894 in/on plant materials by HPLC with electrospray ionization and MS/MS-detection显示文摘 | Sch(o)ning R Placke F J 2001 | 2001 | Pflanzenschutz Nachrichten Bayer2001，54，： | 1 |
| 13 | Adult peripheral lung organ culture-a model for respiratory tract toxicology 显示文摘 | Placke ME Fisher GL | 1987 | Toxicol Appl Pharmacol1987，90，2： | 1 |
| 14 | Method of Determining Imidacloprid Residues in Plant Materials显示文摘 | PLACKE F J WEBER F | 1993 | Pflanzenschulz-Nachrichten Bayer1993，46，2： | 1 |
| 15 | Basilar-membrane Nonlinearity Estimated by Pulsation Threshold显示文摘 | Plack C J Oxenham A J | 2000 | Journal of the Acoustical Society of America2000，107，1： | 1 |
| 16 | Effects of masker frequency and duration in forward masking: further evidence for the influence of peripheral nonlinearity显示文摘 | Oxenham A J Plack C K | 2000 | Hear Res2000，150，12： | 1 |
| 17 | Platelet-derived MHC class I confers a pseudonormal phenotype to cancer cells that subverts the antitumor reactivity of natural killer immune cells显示文摘 | Placke T rgel M Schaller M | 2012 | Cancer Res2012，72，2： | 1 |
| 18 | Platelet - derived transforming growth factor - beta down - regulates NKG2D thereby inhibiting natural killer cell antitumor reactivity 显示文摘 | Kopp HG Placke T Salih HR | 2009 | Cancer Research2009，69，19： | 1 |
| 19 | Gadusol, an enolic derivative of cyclohexane 1,3-dione present in the roes of cod and other marine fish显示文摘 | Plack PA Fraser NW Grant PT | 1981 | Biochemistry1981，199，： | 1 |
| 20 | Plateletderived transforming growth factor-beta down-regulates NKG2D thereby inhibiting natu- ral killer cell antitumor reactivity 显示文摘 | Kopp HG Placke T Salih HR | 2009 | Cancer Res2009，69，19： | 1 |
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