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| 1 | Management of nonalcoholic fatty liver disease:An evidence-based clinical practice review显示文摘AIM:To build a consensus among Chilean specialists on the appropriate management of patients with nonalcoholic fatty liver disease(NAFLD)in clinical practice.METHODS:NAFLD has now reached epidemic proportions worldwide.The optimal treatment for NAFLD has not been established due to a lack of evidence-based recommendations.An expert panel of members of the Chilean Gastroenterological Society and the Chilean Hepatology Association conducted a structured analysis of the current literature on NAFLD therapy.The quality of the evidence and the level of recommendations supporting each statement were assessed according to the recommendations of the United States Preventive Services Task Force.A modified three-round Delphi technique was used to reach a consensus among the experts.RESULTS:A group of thirteen experts was established.The survey included 17 open-ended questions that were distributed among the experts,who assessed the articles associated with each question.The levels of agreement achieved by the panel were 93.8%in the first round and 100%in the second and third rounds.The final recommendations support the indication of lifestyle changes,including diet and exercise,for all patients with NAFLD.Proven pharmacological therapies include only vitamin E and pioglitazone,which can be used in nondiabetic patients with biopsy-proven nonalcoholic steatohepatitis(the progressive form of NAFLD),although the long-term safety and efficacy of these therapies have not yet been established.CONCLUSION:Current NAFLD management is rapidly evolving,and new pathophysiology-based therapies are expected to be introduced in the near future.All NAFLD patients should be evaluated using a three-focused approach that considers the risks of liver disease,diabetes and cardiovascular events. | Juan P Arab Roberto Candia Rodrigo Zapata Cristián Mu?oz Juan P Arancibia Jaime Poniachik Alejandro Soza Francisco Fuster Javier Brahm Edgar Sanhueza Jorge Contreras M Carolina Cuellar Marco Arrese Arnoldo Riquelme | 2014 | World Journal of Gastroenterology2014，20，34： | 11 |
| 2 | Hepatocellular carcinoma in Latin America: Diagnosis and treatment challenges显示文摘Latin America, a region with a population greater than 600000000 individuals, is well known due to its wide geographic, socio-cultural and economic heterogeneity. Access to health care remains as the main barrier that challenges routine screening, early diagnosis and proper treatment of hepatocellular carcinoma(HCC). Therefore, identification of population at risk, implementation of surveillance programs and access to curative treatments has been poorly obtained in the region. Different retrospective cohort studies from the region have shown flaws in the implementation process of routine surveillance and early HCC diagnosis. Furthermore, adherence to clinical practice guidelines recommendations assessed in two studies from Brazil and Argentina demonstrated that there is also room for improvement in this field, similarly than the one observed in Europe and the United States. In summary, Latin America shares difficulties in HCC decision-making processes similar to those from developed countries. However, a transversal limitation in the region is the poor access to health care with the consequent limitation to standard treatments for overall population. Specifically, universal health care access to the different World Health Organization levels is crucial, including improvement in research, education and continuous medical training in order to expand knowledge and generation of data promoting a continuous improvement in the care of HCC patients. | Federico Pinro Jaime Poniachik Ezequiel Ridruejo Marcelo Silva | 2018 | World Journal of Gastroenterology2018，24，37： | 4 |
| 3 | The role of laparo- scopy in the diagnosis of cirrhosis显示文摘 | Poniachik J Bemstein DE Reddy KR | 1996 | Gastrointest Endosc1996，43，6： | 1 |
| 4 | Endoscopic band ligation of bleedingdieulafoy lesions:the best therapeutic strategy显示文摘 | Valera JM Pino RQ Poniachik J | 2006 | Endoscopy2006，38，2： | 1 |
| 5 | Laparoscopic and classic cholecystectomy in patients with liver cirrhosis显示文摘 | Poniachik J Castro S Madrid AM | 2002 | Rev Med Chil2002，130，12： | 1 |
| 6 | Tuberculosis in kidney transplant patients显示文摘 | Paredes R Thambo | 1990 | Rev Med Chil1990，118，10： | 1 |
| 7 | Heparin and insulin treatment of acute pancreatitis caused by hypertrigly ceridemia, experience of 5 cases显示文摘 | BERGER Z QUERA R PONIACHIK J | 2001 | Rev Med Chil2001，129，12： | 1 |
| 8 | Relationship between in vivo chlorzoxazone hydroxylation, hepatic cytochrome P450 2E1 content and liver injury in obese non-alcoholic fatty liver disease patients显示文摘 | Myriam Orellana Ramón Rodrigo Nelson Varela Julia Araya Jaime Poniachik Attila Csendes Gladys Smok Luis A. Videla | 2005 | Hepatology Research2005，，1： | 1 |
| 9 | Obesity:risk factor for steatohepatitis and hepatic fibrosis显示文摘 | PONIACHIK J MANCILLA C CONTRERAS J | 2002 | Rev Med Chil2002，130，7： | 1 |
| 10 | Obesity: risk factor for steatohepatitis and hepatic fibrosis 显示文摘 | Poniachik J Mancilla C Contreras J | 2002 | Rev Med Chil2002，130，： | 1 |
| 11 | The role of laparoscopy in the diagnosis of cirrhosis显示文摘 | Poniachik J Bernsiein DE Reddy KR | 1996 | Gastrointest Endosc1996，43，6： | 1 |
| 12 | Heparin and insulin treatment of acute pancreatitis caused by hypertriglyceridemia:experience of 5 cases显示文摘 | Berger Z Quera R Poniachik J | 2001 | Rev Med Chil2001，129，12： | 1 |
| 13 | Endoscopic band liga- tion, for gastric antral vascular ectasia, Report of two cases显示文摘 | Jaime Poniachik T Zolt d n Berger F Araxi Manugui 6 n G | 2012 | Rev Med Chile2012，140，： | 1 |
| 14 | Oral ulcers produced by mycophenqlate mofetil in two liver transplant patients 显示文摘 | Naranjo J Poniachik J Cisco D | 2007 | Transplant Proc2007，39，3： | 1 |
| 15 | Heparin and insulin treatment of acute pancreatitis caused by hypentriglyceridemia, expefience of 5 cases 显示文摘 | Berger Z Quem R Poniachik J | 2001 | Rev Med Chil2001，129，12： | 1 |
| 16 | Dilinoleoyl phosphatidyl c-holine decrease hepatic stellate cell activat ion显示文摘 | Poniachik J Baraona E Zhao J | 1999 | J Lab Clin Med1999，133，4： | 1 |
| 17 | Collagen synthesis by liver stellate cells is released from its normal feedback regulation by acetaldehyde-induced modification of the carboxyl-terminal propeptide of procollagen显示文摘 | MA X SVEGLIATI-BARONI G PONIACHIK J | 1997 | Alcohol Clin Exp Res1997，21，： | 1 |
| 18 | Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation显示文摘 | PONIACHIK J BARAONA E ZHAO J | 1999 | J Lab Clin Med1999，133，： | 1 |
| 19 | Obesity:risk factor for steatohepatitis and hepatic fibrosis显示文摘 | PONIACHIK J MANCILLA C CONTRERAS J | 2002 | Rev Med Chil2002，130，5： | 1 |
| 20 | Laparoscopic and classic cholecystectomy in patients with liver cirrhosis IJJ 显示文摘 | Poniachik J Castro S Madrid AM | 2002 | Rev Med Chil2002，130，12： | 1 |
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