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| 1 | Relationships between mucinous gastric carcinoma, MUC2 expression and survival显示文摘瞄准:为了调查四的表示,在一系列胃的癌分泌了形成胶化的粘蛋白( MUC2 , MUC5AC , MUC5B 和 MUC6 ),分类 Lauren 的,素菜烩肉的,并且 Goseki 的分类,与到所有的特殊注意,不同部件(专业和未成年者)在肿瘤并且到介绍在临床的数据上面列在后面。方法:MUC2, MUC5AC, MUC5B 和 MUC6 的表示用免疫组织化学和原位杂交被调查。结果:在胃的癌的分泌形成胶化的粘蛋白的表示是特别地复杂的,各粘蛋白 being 没限制到平的任何组织病理学说的类型在一个给定的肿瘤认为所有部件(专业和未成年者) 是现在。在有粘液(Goseki II 或 IV ) 和高积极 MUC2 表示的一个更高的内容的病人有最糟的幸存。结论:在胃的癌症的粘蛋白基因表达式模式的复杂性可以在没在使用的词法分类系统认出的房间水平反映区别的一个精确状态。MUC2 的高表示不过与 WHO 分类的粘蛋白的子类型并且与 Goseki 一个特别肿瘤的主要部件识别的分类的组 II 被联系。粘液的数量和质量与幸存有关。 | Emmanuelle Leteurtre Farid Zerimech Guillaume Piessen Agnès Wacrenier Xavier Leroy Marie-Christine Copin Christophe Mariette Jean-Pierre Aubert Nicole Porchet Marie-Pierre Buisine | 2006 | World Journal of Gastroenterology2006，12，21： | 4 |
| 2 | Frequent mutations of the CA simple sequence repeat in intron 1 of EGFR in mismatch repair-deficient colorectal cancers显示文摘AIM:To investigate the polymorphic simple sequencerepeat in intron 1 of the epidermal growth factor receptorgene(EGFR)(CA-SSRⅠ),which is known to affect theefficiency of gene transcription as a putative target of themismatch repair(MMR)machinery in colorectal tumors.METHODS:The CA-SSRⅠgenotype was analyzed ina total of 86 primary colorectal tumors,selected upontheir microsatellite instability(MSI)status[42 with highfrequency MSI(MSI-H)and 44 microsatellite stable(MSS)]and their respective normal tissue.The effect of the CA-SSRⅠgenotype on the expression of the EGFR gene wasevaluated in 18 specimens using quantitative real-timereverse transcription PCR and immunohistochemistry.RESULTS:Mutations in CA-SSRⅠwere detected in 86%(36 of 42)of MSI-H colorectal tumors and 0%(0 of 44)ofMSS tumors,indicating the EGFR gene as a novel putativespecific target of the defective MMR system(P<0.001).Impaired expression of EGFR was detected in most ofthe colorectal tumors analyzed[6/12(50%)at the mRNAlevel and 15/18(83%)at the peptide level].However,noassociation was apparent between EGFR expression andCA-SSRⅠstatus in tumors or normal tissues.CONCLUSION:Our results suggest that CA-SSRⅠsequence does not contribute to the regulation of EGFRtranscription in colon,and should thus not be consideredas a promising predictive marker for response to EGFRinhibitors in patients with colorectal cancer. | Marie-Pierre Buisine Agnès Wacrenier Christophe Mariette Emmanuelle Leteurtre Fabienne Escande Sana Aissi Amandine Ketele Annette Leclercq Nicole Porchet Thécla Lesuffleur | 2008 | World Journal of Gastroenterology2008，14，7： | 3 |
| 3 | Longterm follow up of patients surgically treated by the far-lateral approach for foraminal and extraforaminal lumbar disc herniations 显示文摘 | Porchet F Chollect-Bornand A de Tribolet N | 1999 | J Neurosurg1999，90，1： | 1 |
| 4 | Surgical treatment of lumbar spinal stenosis:Five-year follow-up显示文摘 | Jolles BM Porchet F Theumann N | 2001 | J Bone Joint Surg Br2001，83，7： | 1 |
| 5 | Molecular cloning and chromosomal localization of a novel human tracheo-bronchial mucin cDNA containing tandemly repeated sequences of 48 base pairs 显示文摘 | N Porchet Nguyen Van Cong J Dufosse | 1991 | Biochem Biophys Res Commun1991，175，2： | 1 |
| 6 | A generic Petri net model for dy- namic process planning and sequence optimization 显示文摘 | KIRITIS D PORCHET M | 1996 | Ad- vances in Engineering Softwares1996，25，1： | 1 |
| 7 | MUC genes: Mucin or not mucin? That is the quesdon显示文摘 | Porchet N Aubert JP | 2004 | Med Sci (Paris)2004，20，5： | 1 |
| 8 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，6，： | 1 |
| 9 | A generic Petri net model for dynamic process planning and sequence optimization 显示文摘 | Dimitris Kiritis Michel Porchet | 1996 | Advances in Engineering Softwares1996，25，： | 1 |
| 10 | Microdiscectomy compared with standard discectomy: an old problem revisited with new outcome measures within the framework of a spine surgical registry显示文摘 | Porchet F Bartanusz V Kleinstueck FS | 2009 | Eur Spine J2009，18，3： | 1 |
| 11 | Surgical treatment of lumbar spinal stenosis : five - year follow - up 显示文摘 | Jolles B M Porchet F Theumann N | 2001 | J Bone Joint Surg ( Br)2001，83，7： | 1 |
| 12 | Long term follow-up of patients surgically treated by the far lateral approach for foraminal and extraforaminal lumbar disc hemiations显示文摘 | PORCHET F CHOLLET-BORNAND A D E TRIBOLET N | 1999 | J Neurosurg1999，90，： | 1 |
| 13 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，6，： | 1 |
| 14 | Structural organization and classification of the human mucin genes显示文摘 | MONIAUX N ESCANDE F PORCHET N | 2001 | Front Biosci2001，6，： | 1 |
| 15 | Extreme lateral lumbar disc herniation: clinical presentation in 178 patients显示文摘 | Porchet F Fankhauser H de Tribolet N | 1994 | Acta Neurochir1994，4，： | 1 |
| 16 | Comlete sequence of the human mucin MUCA ;a putative cell membrane-associated mucin 显示文摘 | Moniaux N Nollet S Porchet N | 1999 | Biochem J1999，338，： | 1 |
| 17 | Hypotensive effect of nimodipine during treatment for aneurysmal subarachnoid haemorrhage 显示文摘 | Porchet F Chiolero R de Tribolet N | 1995 | Acta Neurochirurgica1995，137，12： | 1 |
| 18 | Structural organization and classification of the human mucin genes显示文摘 | Moniaux N Escande F Porchet N | 2001 | Front Biosci2001，10，10： | 1 |
| 19 | Human mucin gene MUC5AC:organization of its 5′-region and central repetivive region显示文摘 | Escande F aubert JP Porchet N | 2001 | Biochen J2001，358，3： | 1 |
| 20 | Inhibition of epidural fibrosis with ADCON-L:effect on clinical outcome one year following re-operation for recurrent lumbar radiculopathy显示文摘 | Lombardi D De Preux J | 1999 | Neurol Res1999，21，1： | 1 |
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