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| 1 | Potential role of Th17 cells in the pathogenesis of inflammatory bowel disease显示文摘The etiopathology of inflammatory bowel disease(IBD)remains elusive.Accumulating evidence suggests that the abnormality of innate and adaptive immunity responses plays an important role in intestinal inflammation.IBD including Crohn's disease(CD)and ulcerative colitis(UC)is a chronic inflammatory disease of the gastrointestinal tract,which is implicated in an inappropriate and overactive mucosal immune response to luminalflora.Traditionally,CD is regarded as a Th1-mediated inflammatory disorder while UC is regarded as a Th2-like disease.Recently,Th17 cells were identif ied as a new subset of T helper cells unrelated to Th1 or Th2 cells,and several cytokines [e.g.interleukin(IL)-21,IL-23] are involved in regulating their activation and differentiation.They not only play an important role in host defense against extracellular pathogens,but are also associated with the development of autoimmunity and inflammatory response such as IBD.The identif ication of Th17 cells helps us to explain some of the anomalies seen in the Th1/Th2 axis and has broadened our understanding of the immunopathological effects of Th17 cells in the development of IBD. | Zhan-Ju Liu Praveen K Yadav Jing-Ling Su Jun-Shan Wang Ke Fei | 2009 | World Journal of Gastroenterology2009，15，46： | 44 |
| 2 | Expanding Roles of PIFs in Signal Integration from Multiple Processes显示文摘交往 PHYTOCHROME 因素(程序信息文件) 是基本 helix-loop-helix (bHLH ) 的成员在 Arabidopsis 的抄写因素的家庭。自从他们在调停 phytochrome 的轻发信号小径的发现,最近的研究解开了在作为直接指向基因表示的抄写因素通过他们的角色集成多重发信号的小径的程序信息文件的新函数不仅 ? 而且由与因素的多样的组一起交往优化植物生长和开发。这些包括内长(例如,神经质) 象一样不能生活(光,生理节奏,并且提高的温度) 并且关於生命(防卫回答) 小径。程序信息文件在每这些小径与关键因素交往 ? 并且在这些小径之中定制信号集成的结果。这评论在调整植物生长和开发讨论程序信息文件同样枢轴的信号综合者的角色。 | Inyup Paik Praveen Kumar Kathare Jeong-II Kim Enamul Huq | 2017 | Molecular Plant2017，10，8： | 15 |
| 3 | Selective embolization for bleeding visceral artery pseudoaneurysms in patients with pancreatitis显示文摘BACKGROUND:Pancreatitis is associated with arterial complications in 4%-10%of patients,with untreated mortality approaching 90%.Timely intervention at a specialist center can reduce the mortality to 15%.We present a single institution experience of selective embolization as first line management of bleeding pseudoaneurysms in pancreatitis. METHODS:Sixteen patients with pancreatitis and visceral artery pseudoaneurysms were identified from searches of the records of interventional angiography from January 2000 to June 2007.True visceral artery aneurysms and pseudoaneurysms arising as a result of post-operative pancreatic or biliary leak were excluded from the study. RESULTS:In 50%of the patients,bleeding complicated the initial presentation of pancreatitis.Alcohol was the offending agent in 10 patients,gallstones in 3,trauma,drug-induced and idiopathic pancreatitis in one each.All 16 patients had a contrast CT scan and 15 underwent coeliac axis angiography. The pseudoaneurysms ranging from 0.9 to 9.0 cm affected the splenic artery in 7 patients:hepatic in 3,gastroduodenal and right gastric in 2 each,and left gastric and pancreatico-duodenal in 1 each.One patient developed spontaneous thrombosis of the pseudoaneurysm.Fourteen patients had effective coil embolization of the pseudoaneurysm.One patient needed surgical exclusion of the pseudoaneurysm following difficulty in accessing the coeliac axis radiologically.There were no episodes of re-bleeding and no in-hospital mortality. CONCLUSIONS:Pseudoaneurysms are unrelated to the severity of pancreatitis and major hemorrhage can occur irrespective of their size.Co-existent portal hypertension and sepsis increase the risk of surgery.Angiography and selective coil embolization is a safe and effective way to arrest the hemorrhage. | Harsheet Sethi Praveen Peddu Andreas Prachalias Pauline Kane John Karani Mohamed Rela Nigel Heaton | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，6： | 12 |
| 4 | Comparative evaluation of intragastric bile acids and hepatobiliary scintigraphy in the diagnosis of duodenogastric reflux显示文摘AIM:To assess the diagnostic value of a combination of intragastric bile acids and hepatobiliary scintigraphy in the detection of duodenogastric reflux(DGR).METHODS:The study contained 99 patients with DGR and 70 healthy volunteers who made up the control group.The diagnosis was based on the combination of several objective arguments:a long history of gastric symptoms(i.e.,nausea,epigastric pain,and/or bilious vomiting) poorly responsive to medical treatment,gastroesophageal reflux symptoms unresponsive to protonpump inhibitors,gastritis on upper gastrointestinal(GI) endoscopy and/or at histology,presence of a bilious gastric lake at > 1 upper GI endoscopy,pathologic 24-h intragastric bile monitoring with the Bilitec device.Gas-tric juice was aspirated in the GI endoscopy and total bile acid(TBA),total bilirubin(TBIL) and direct bilirubin(DBIL) were tested in the clinical laboratory.Continuous data of gastric juice were compared between each group using the independent-samples Mann-Whitney U-test and their relationship was analysed by Spearman's rank correlation test and Fisher's linear discriminant analysis.Histopathology of DGR patients and 23 patients with chronic atrophic gastritis was compared by clinical pathologists.Using the Independent-samples Mann-Whitney U-test,DGR index(DGRi) was calculated in 28 patients of DGR group and 19 persons of control group who were subjected to hepatobiliary scintigraphy.Receiver operating characteristic curve was made to determine the sensitivity and specificity of these two methods in the diagnosis of DGR.RESULTS:The group of patients with DGR showed a statistically higher prevalence of epigastric pain in comparison with control group.There was no significant difference between the histology of gastric mucosa with atrophic gastritis and duodenogastric reflux.The bile acid levels of DGR patients were significantly higher than the control values(Z:TBA:-8.916,DBIL:-3.914,TBIL:-6.197,all P < 0.001).Two of three in the DGR group have a significantly associated with each other(r:TBA/DBIL:0.362,TBA/TBIL:0.470,DBIL/TBIL:0.737,all P < 0.001).The Fisher's discriminant function is followed:Con:Y = 0.002TBA + 0.048DBIL + 0.032TBIL 0.986;Reflux:Y = 0.012TBA + 0.076DBIL + 0.089TBIL-2.614.Eighty-four point zero five percent of original grouped cases were correctly classified by this method.With respect to the DGR group,DGRi were higher than those in the control group with statistically significant differences(Z =-5.224,P < 0.001).Twenty eight patients(59.6%) were deemed to be duodenogastric reflux positive by endoscopy,as compared to 37 patients(78.7%) by hepatobiliary scintigraphy.CONCLUSION:The integrated use of intragastric bile acid examination and scintigraphy can greatly improve the sensitivity and specificity of the diagnosis of DGR. | Teng-Fei Chen Praveen K Yadav Rui-Jin Wu Wei-Hua Yu Chang-Qin Liu Hui Lin Zhan-Ju Liu | 2013 | World Journal of Gastroenterology2013，19，14： | 12 |
| 5 | Methane hydrates:A future clean energy resource显示文摘Natural gas has been considered as the best transition fuel into the future carbon constraint world.The ever-increasing demand for natural gas has prompted expanding research and development activities worldwide for exploring methane hydrates as a future energy resource.With its vast global resource volume(~3000 trillion cubic meter CH4)and high energy storage capacity(170 CH4 v/v methane hydrate),recovering energy from naturally-occurring methane hydrate has attracted both academic and industry interests to demonstrate the technical feasibility and economic viability.In this review paper,we highlight the recent advances in fundamental researches,seminal discoveries and implications from ongoing drilling programs and field production tests,the impending knowledge gaps and the future perspectives of recovering energy from methane hydrates.We further emphasize the current scientific,technological and economic challenges in realizing long-term commercial gas production from methane hydrate reservoir.The continuous growth of the corresponding experimental studies in China should target these specific challenges to narrow the knowledge gaps between laboratory-scale investigations and reservoir-scale applications.Furthermore,we briefly discuss both the environmental and geomechanical issues related to exploiting methane hydrate as the future energy resource and believe that they should be of paramount importance in the future development of novel gas production technologies. | Zhenyuan Yin Praveen Linga | 2019 | Chinese Journal of Chemical Engineering2019，27，9： | 12 |
| 6 | State coordinated voltage control in an active distribution network with on-load tap changers and photovoltaic systems显示文摘Decreasing costs and favorable policies have resulted in increased penetration of solar photovoltaic(PV)power generation in distribution networks.As the PV systems penetration is likely to increase in the future,utilizing the reactive power capability of PV inverters to mitigate voltage deviations is being promoted.In recent years,droop control of inverter-based distributed energy resources has emerged as an essential tool for use in this study.The participation of PV systems in voltage regulation and its coordination with existing controllers,such as on-load tap changers,is paramount for controlling the voltage within specified limits.In this work,control strategies are presented that can be coordinated with the existing controls in a distributed manner.The effectiveness of the proposed method was demonstrated through simulation results on a distribution system. | Praveen Prakash Singh Ivo Palu | 2021 | Global Energy Interconnection2021，4，2： | 11 |
| 7 | Effect of IOP based infusion system with and without balanced phaco tip on cumulative dissipated energy and estimated fluid usage in comparison to gravity fed infusion in torsional phacoemulsification显示文摘Background:To evaluate the effect of three different combinations of tip designs and infusion systems in torsional phacoemulsification(INFINITI and CENTURION)in patients with cataract.According to the manufacturer,two unique improvements in the Centurion are:active fluid dynamic management system and use of an intrepid balanced tip.The study specifically aimed to evaluate the beneficial effects,if any,of change in tip design and infusion system individually and in combination on both per-operative parameters as well as endothelial health over 6 months.Methods:One hundred and twenty six consenting patients of grade 4.0-6.9 senile cataract were randomized into three groups for phacoemulsification:Group A(n=42):Gravity fed infusion system and 45° Kelman miniflared ABS phaco tip;Group B(n=42):intraocular pressure(IOP)based infusion system and 45° Kelman miniflared ABS phaco tip;Group C(n=42):IOP based infusion system and 45° Intrepid balanced phaco tip.The cumulative dissipated energy(CDE),estimated fluid usage(EFU)and total aspiration time(TAT)were compared peroperatively.The endothelial parameters were followed up postoperatively for six months.Results:The three arms were matched for age(p=0.525),gender(p=0.96)and grade of cataract(p=0.177).Group C was associated with significant reductions in CDE(p=0.001),EFU(p<0.0005)as well as TAT(p=0.001)in comparison to the other groups.All three groups had comparable baseline endothelial cell density(p=0.876)and central corneal thickness(p=0.561).On post-operative evaluation,although all groups were comparable till 3 months,by 6 months,the percentage losses in endothelial cell density were significantly lower in group C as compared to the other groups.Conclusions:Use of an IOP based phacoemulsification system in association with use of the Intrepid balanced tip reduces the CDE,EFU and TAT in comparison to a gravity fed system with a mini flared tip or IOP based system with a mini flared tip while also providing better endothelial preservation thus favouring the use of an IOP fed system with a balanced tip. | Praveen K.Malik Taru Dewan Arun Kr Patidar Ekta Sain | 2017 | Eye and Vision2017，4，1： | 11 |
| 8 | The role of the androgen receptor in prostate development and benign prostatic hyperplasia:A review显示文摘Benign prostatic hyperplasia(BPH)is a benign enlargement of the prostate in which incidence increases linearly with age,beginning at about 50 years old.BPH is a significant source of morbidity in aging men by causing lower urinary tract symptoms and acute urinary retention.Unfortunately,the etiology of BPH incidence and progression is not clear.This review highlights the role of the androgen receptor(AR)in prostate development and the evidence for its involvement in BPH.The AR is essential for normal prostate development,and individuals with defective AR signaling,such as after castration,do not experience prostate enlargement with age.Furthermore,decreasing dihydrotestosterone availability through therapeutic targeting with 5a-reductase inhibitors diminishes AR activity and results in reduced prostate size and symptoms in some BPH patients.While there is some evidence that AR expression is elevated in certain cellular compartments,how exactly AR is involved in BPH progression has yet to be elucidated.It is possible that AR signaling within stromal cells alters intercellular signaling and a“reawakening”of the embryonic mesenchyme,loss of epithelial AR leads to changes in paracrine signaling interactions,and/or chronic inflammation aids in stromal or epithelial proliferation evident in BPH.Unfortunately,a subset of patients fails to respond to current medical approaches,forcing surgical treatment even though age or associated co-morbidities make surgery less attractive.Fundamentally,new therapeutic approaches to treat BPH are not currently forthcoming,so a more complete molecular understanding of BPH etiology is necessary to identify new treatment options. | Renee E.Vickman Omar E.Franco Daniel C.Moline Donald J.Vander Griend Praveen Thumbikat Simon W.Hayward | 2020 | Asian Journal of Urology2020，7，3： | 11 |
| 9 | Male sexual dysfunction in Asia显示文摘性总是是在亚洲社会的一个禁忌题目。在过去几年,然而,人的性健康的领域里的了解改善了,并且对性健康研究的兴趣最近增加了。在亚洲的可勃起的机能障碍,性腺机能减退和早泄的传染病学和流行在韦斯特是类似的。然而,几个问题对亚洲男性特定,包括文化和信仰,了解,依从和传统 / 补足的药的可获得性。在亚洲,性药仍然在它的幼年期,并且从政府,相关社会,医生和媒介的一个一致努力被要求推进性药到护理的最前线。 | Christopher CK Ho Praveen Singam Goh Eng Hong Zulkifli Md Zainuddin | 2011 | Asian Journal of Andrology2011，13，4： | 10 |
| 10 | Critical flicker frequency for diagnosis and assessment of recovery from minimal hepatic encephalopathy in patients with cirrhosis显示文摘BACKGROUND:Minimal hepatic encephalopathy (MHE) impairs quality of life and predicts overt hepatic encephalopathy (HE) in cirrhotic patients.Diagnosis of MHE requires cumbersome tests.Lactulose is effective in the treatment of MHE.This study aimed to evaluate the use of critical flicker frequency (CFF) for the diagnosis of MHE in cirrhotic patients after treatment.METHODS:One hundred and ten patients were evaluated by psychometry (number connection tests A,B or figure connection tests A,B),P300 auditory event related potential (P300ERP),venous ammonia,and CFF for MHE.MHE was diagnosed by abnormal psychometry (>2SD age matched controls) and P300ERP.MHE patients were treated with lactulose for one month.Response was defined by normalization (<2SD of matched controls) of both psychometry and P300ERP.RESULTS:Of the 110 patients [Child Turcott Pugh score A:B:C 39:42:29,(age 41.6±11.6 years,M:F 82:28)],75 (68%) had abnormal results of psychometric tests,and 74 (67%) had prolonged P300ERP.Fifteen (20%) patients with abnormal results of psychometric tests had normal P300ERP.Thus sixty (54.5%) patients were diagnosed as having MHE.After treatment for one month,34 (57%) recovered while 26 (43%) continued to have abnormal resents of psychometric or P300ERP tests.CFF was <39 Hz in 72 (65.4%) patients before treatment and in 20 (33.3%) after treatment.CFF sensitivity,specificity,positive predictive value,negative predictive value,and diagnostic accuracy for the assessment of recovery of MHE were 65%,91%,85%,77% and 80%,respectively.CONCLUSION:CFF is a simple,relatively reliable,and accurate test without any dependence on age or literacy in the diagnosis and assessment of recovery of patients with MHE. | Praveen Sharma Barjesh Chander Sharma Shiv Kumar Sarin | 2010 | Hepatobiliary & Pancreatic Diseases International2010，9，1： | 10 |
| 11 | Oxidative Stressand Antioxidant Responses in Young Leaves of Mulberry Plants Grown Under Nitrogen, Phosphorus or Potassium Deficiency显示文摘 | Rajesh Kumar Tewari Praveen Kumar Parma Nand Sharma | 2007 | Journal of Integrative Plant Biology2007，49，3： | 10 |
| 12 | Role of the JNK signal transduction pathway in inflammatory bowel disease显示文摘The c-Jun NH2-terminal Kinase (JNK) pathway representsone sub-group of the mitogen-activated protein (MAP)kinases which plays an important role in variousinflammatory diseases states, including inflammatorybowel disease (IBD). Significant progress towardsunderstanding the function of the JNK signaling pathwayhas been achieved during the past few years. Blockadeof the JNK pathway with JNK inhibitors in animal modelsof IBD lead to resolution of intestinal inflammation.Current data suggest specific JNK inhibitors hold promiseas novel therapies in IBD. | Praveen K Roy Farzana Rashid Jack Bragg Jamal A Ibdah | 2008 | World Journal of Gastroenterology2008，14，2： | 10 |
| 13 | Global characterization and monitoring of forest cover using Landsat data: opportunities and challenges显示文摘The compilation of global Landsat data-sets and the ever-lowering costs of computing now make it feasible to monitor the Earth’s land cover at Landsat resolutions of 30 m.In this article,we describe the methods to create global products of forest cover and cover change at Landsat resolutions.Nevertheless,there are many challenges in ensuring the creation of high-quality products.And we propose various ways in which the challenges can be overcome.Among the challenges are the need for atmospheric correction,incorrect calibration coefficients in some of the data-sets,the different phenologies between compila-tions,the need for terrain correction,the lack of consistent reference data for training and accuracy assessment,and the need for highly automated character-ization and change detection.We propose and evaluate the creation and use of surface reflectance products,improved selection of scenes to reduce phenological differences,terrain illumination correction,automated training selection,and the use of information extraction procedures robust to errors in training data along with several other issues.At several stages we use Moderate Resolution Spectro-radiometer data and products to assist our analysis.A global working prototype product of forest cover and forest cover change is included. | John R.Townshend Jeffrey G.Masek Chengquan Huang Eric.F.Vermote Feng Gao Saurabh Channan Joseph O.Sexton Min Feng Raghuram Narasimhan Dohyung Kim Kuan Song Danxia Song Xiao-Peng Song Praveen Noojipady Bin Tan Matthew C.Hansen Mengxue Li Robert E.Wolfe | 2012 | International Journal of Digital Earth2012，5，5： | 10 |
| 14 | Plant Small RNAs: Biogenesis, Mode of Action and Their Roles in Abiotic Stresses显示文摘Small RNAs (sRNAs) are 18-30 nt non-coding regulatory elements found in diverse organisms, which were initially identified as small double-stranded RNAs in Caenorhabditis elegans. With the development of new and improved technologies, sRNAs have also been identified and characterized in plant systems. Among them, micro RNAs (miRNAs) and small interfering RNAs (siRNAs) are found to be very important riboregulators in plants. Various types of sRNAs differ in their mode of biogenesis and in their function of gene regulation. sRNAs are involved in gene regulation at both transcriptional and post-transcriptional levels. They are known to regulate growth and development of plants. Furthermore, sRNAs especially plant miRNAs have been found to be involved in various stress responses, such as oxidative, mineral nutrient deficiency, dehydration, and even mechanical stimulus. Therefore, in the present review, we focus on the current understanding of biogenesis and regulatory mechanisms of plant sRNAs and their responses to various abiotic stresses. | Praveen Guleria Monika Mahajan Jyoti Bhardwaj Sudesh Kumar Yadav | 2011 | Genomics, Proteomics & Bioinformatics2011，9，6： | 10 |
| 15 | Hybrid, Optimal, Intelligent and Classical PV MPPT Techniques: A Review显示文摘Renewable energy-based solar photovoltaic(PV)generation is the best alternative for conventional energy sources because of its natural abundance and environment friendly characteristics.Maximum power extraction from the PV system plays a critical role in increasing the efficiency of the solar power generation during partial shading conditions(PSCs).Therefore,a suitable maximum power point tracking(MPPT)technique to track the maximum power point(MPP)is of high need,even under PSCs.This paper presents an organized and concise review of MPPT techniques implemented for the PV systems in literature along with recent publications on various hardware design methodologies.Their classification is done into four categories,i.e.classical,intelligent,optimal,and hybrid depending on the tracking algorithm utilized to track MPP under PSCs.During uniform insolation,classical methods are highly preferred as there is only one peak in the P-V curve.However,under PSCs,the F-V curve exhibits multiple peaks,one global maximum power point(GMPP)and remaining are local maximum power points(LMPP’s).Under the PSCs,classical methods fail to operate at GMPP and hence there is a need for more advanced MPPT techniques.Every MPPT technique has its advantages and limits,but a streamlined MPPT is drafted in numerous parameters like sensors required,hardware implementation,cost viability,tracking speed and tracking efficiency.This study provides the advancement in this area since some parameter comparison is made at the end of every classification,which might be a prominent base-rule for picking the most gainful sort of MPPT for further research. | Ratnakar Babu Bollipo Suresh Mikkili Praveen Kumar Bonthagorla | 2021 | CSEE Journal of Power and Energy Systems2021，7，1： | 10 |
| 16 | 血管迷走性晕厥患者与身高体质量及人体质量指数的关系显示文摘目的探讨血管迷走性晕厥(VVS)患者与身高、体质量及人体质量指数(BMI)的关系。方法2001-01~2007-08在中南大学湘雅二医院晕厥专科门诊就诊或住院的不明原因晕厥(UPS)或先兆晕厥患者418例,经直立倾斜试验(HUTT)检查阳性诊断为VVS,其中4~17岁[平均(11·37±2·99)岁]223例(儿童组),18~70岁[平均(36·82±13·64)岁]195例(成人组)。测量身高、体质量,计算BMI。结果成人组HUTT阳性患者、HUTT阴性患者BMI在头晕组稍高于晕厥组(P>0·05);HUTT阴性组较HUTT阳性组BMI及体质量明显增高(P<0·01),两组身高比较差异无统计学意义(P>0·05)。儿童组BMI在各年龄段HUTT阴性组与HUTT阳性组比较差异均无统计学意义(P>0·05)。儿童HUTT阳性组或HUTT阴性组BMI与年龄均呈直线相关,两组直线回归显示,16岁以下儿童BMI在HUTT阴性组高于HUTT阳性组,16岁以上则呈相反变化。结论成人低体质量和低BMI者晕厥易感性增加,儿童BMI与晕厥易感性相关不密切。 | 丁异熠 王成 薛小红 李茗香 林萍 刘晓燕 Praveen Kumar 胡春艳 | 2008 | 中国急救医学2008，28，2： | 9 |
| 17 | 血管迷走性晕厥直立倾斜试验反应类型分布特征的研究显示文摘目的研究血管迷走性晕厥(VVS)患者在直立倾斜试验(HUTT)中不同反应类型的分布特征,探讨HUTT不同反应类型与VVS临床表现的关系。方法收集2007年1月至2008年4月在中南大学湘雅二医院就诊的HUTT阳性的VVS患者90例,分析HUTT不同反应类型的临床特点,比较各反应类型在性别、发病初始年龄及HUTT反应时间等方面的差异。结果90例HUTT阳性患者中男29例,女61例;血管抑制型68.9%(62/90),混合型30.0%(27/90),心脏抑制型1.1%(1/90)。VVS患者发病季节以夏季多见(47.8%)。各反应类型之间男女性别比例差异无统计学意义(P>0.05);混合型患者病程显著长于血管抑制型患者(P<0.05);年龄、发病初始年龄、基础心率及基础收缩压和舒张压,在血管抑制型和混合型之间比较差异无统计学意义(P>0.05);基础直立倾斜试验(BHUT)阶段混合型的平均反应时间较血管抑制型缩短(P<0.05)。结论VVS以女性常见,VVS患者初发年龄主要集中在10岁左右,HUTT不同反应类型与临床表现有一定关系。 | 刘晓燕 何芝香 王成 林萍 李茗香 薛小红 吴礼嘉 胡春艳 Praveen Kumar 丁异熠 | 2009 | 中国实用内科杂志2009，29，3： | 8 |
| 18 | Correlation of transient elastography with hepatic venous pressure gradient in patients with cirrhotic portal hypertension: A study of 326 patients from India显示文摘AIM To study the diagnostic accuracy of transient elastography(TE) for detecting clinically significant portal hypertension(CSPH) in Indian patients with cirrhotic portal hypertension.METHODS This retrospective study was conducted at the Institute of Liver, Gastroenterology, and Panceatico-Biliary Sciences, Sir Ganga Ram Hospital, New Delhi, on consecutive patients with cirrhosis greater than 15 years of age who underwent hepatic venous pressure gradient(HVPG) and TE from July 2011 to May 2016. Correlation between HVPG and TE was analyzed using the Spearman's correlation test. Receiver operating characteristic ( ROC) curves were prepared for determining the utility of TE in predicting various stages of portal hypertension. The best cut-off value of TE forthe diagnosis of CSPH was obtained using the Youden index.RESULTS The study included 326 patients [median age 52(range 16-90) years; 81% males]. The most common etiology of cirrhosis was cryptogenic(45%) followed by alcohol(34%). The median HVPG was 16.0(range 1.5 to 30.5) mm Hg. Eighty-five percent of patients had CSPH. A significant positive correlation was noted between TE and HVPG(rho 0.361, P < 0.001). The area under ROC curve for TE in predicting CSPH was 0.740(95%CI: 0.662-0.818)(P < 0.01). A cut-off value of TE of 21.6 k Pa best predicted CSPH with a positive predictive value(PPV) of 93%.CONCLUSION TE has a fair positive correlation with HVPG; thus, TE can be used as a non-invasive modality to assess the degree of portal hypertension. A cut-off TE value of 21.6 k Pa identifies CSPH with a PPV of 93%. | Ashish Kumar Noor Muhammad Khan Shrihari Anil Anikhindi Praveen Sharma Naresh Bansal Vikas Singla Anil Arora | 2017 | World Journal of Gastroenterology2017，23，4： | 8 |
| 19 | 血管迷走性晕厥儿童24h尿电解质含量变化显示文摘目的探讨血管迷走性晕厥儿童24h尿电解质含量变化,对临床补盐补液治疗提供依据。方法2004-06~2007-04在中南大学湘雅二医院晕厥专科门诊就诊或住院的不明原因晕厥或先兆晕厥儿童79例(晕厥组),男31例,女48例,平均年龄(11.18±2.47)岁。匹配健康儿童11例为对照(对照组)。研究对象留取24h尿,测量尿量后,采用日本HITACHI公司7600-020全自动生化分析仪检测24h尿电解质(钾、钠、氯、钙、磷、镁)含量。结果①晕厥组24h尿量较对照组减少(P>0.05),24h尿电解质含量变化不明显(P>0.05),每毫升尿钠和尿钙增加(P<0.01或P<0.05)。②晕厥儿童HUTT阳性组24h尿钠、尿钾较HUTT阴性组明显增加(P<0.05),每毫升尿钠增加(P<0.05)。③晕厥儿童24h尿电解质含量和每毫升尿电解质含量在血管抑制型与心脏抑制型+混合型组、男女性别、<12岁组与≥12岁组、晕厥频次<4次组和晕厥频次≥4次组之间比较差异无统计学意义(P>0.05)。结论24h尿钠含量增加与VVS发病关系密切,临床治疗VVS要强调健康教育,重视补盐补液方案。 | 王成 刘晓燕 郑慧芬 李雯 薛小红 丁异熠 胡春艳 Praveen Kumar 吴礼嘉 | 2008 | 中国急救医学2008，28，11： | 8 |
| 20 | Evaluation and management of acute pancreatitis显示文摘Acute pancreatitis(AP) is one of the most common gastrointestinal causes for hospi-talization in the United States. In 2015, AP accounted for approximately390000 hospitalizations. The burden of AP is only expected to increase over time.Despite recent advances in medicine, pancreatitis continues to be associated with a substantial morbidity and mortality. The most common cause of AP is gallstones, followed closely by alcohol use. The diagnosis of pancreatitis is established with any two of three following criteria:(1) Abdominal pain consistent with that of AP;(2) Serum amylase and/or lipase greater than three times the upper limit of normal; and(3) Characteristics findings seen in crosssectional abdominal imaging. Multiple criteria and scoring systems have been established for assessing severity of AP. The cornerstones of management include aggressive intravenous hydration, appropriate nutrition and pain management.Endoscopic retrograde cholangiopancreatography and surgery are important aspects in management of acute gallstone pancreatitis. We provide a comprehensive review of evaluation and management of AP. | Ahmed T Chatila Mohammad Bilal Praveen Guturu | 2019 | World Journal of Clinical Cases2019，7，9： | 8 |
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