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| 1 | Anti-diabetic potential of Urena lobata leaf extract through inhibition of dipeptidyl peptidase IV activity显示文摘Objective: To evaluate the anti-diabetic potential of leaf extract from Urena lobata(U. lobata) through dipeptidyl peptidase IV(DPP-IV) inhibitory activity.Methods: U. lobata leaf was extracted in hot water and ethanol. The activity of DPPIV inhibitor was tested by in vitro study using gly-pro-p-nitroanilide as substrat of DPPIV and vildagliptin, as standard reference. A product of the reactions between gly-pro-pnitroanilide and DPP-IV, was observed by microplate readers with λ = 405 nm. All data were expressed as mean ± SD and the IC50 value was determined by non linear regression curve fit. Active substances in leaf extract of U. lobata was analyzed by liquid chromatography-mass spectrometry. DPP-IV inhibitory activity of active compounds was evaluated in silico using docking server. Results: The ethanolic extract of U. lobata showed stronger DPP-IV inhibitor activity than water extract with the IC50 values of 1 654.64 and 6 489.88 μg/mL, respectively. Vildagliptin, based on standard reference for DPP-IV inhibitor activity, has IC50 value of 57.44 μg/mL. Based on in silico analysis, mangiferin, stigmasterol and β-sitosterol in U. lobata extract have a strong inhibitory activity on DPP-IV. Conclusions: The results showed that DPP-IV inhibitory activity of U. lobata is related to its active compounds such as mangiferin, stigmasterol and β-sitosterol. | Yudi Purnomo Djoko Wahono Soeatmadji Sutiman Bambang Sumitro Mochammad Aris Widodo | 2015 | Asian Pacific Journal of Tropical Biomedicine2015，5，8： | 2 |
| 2 | Ganglion cells apoptosis in diabetic rats as early prediction of glaucoma:a study of Brn3b gene expression and association with change of quantity of NO, caspase-3, NF-κB, and TNF-α显示文摘AIM:To find a new concept to show whether or not apoptosis of retinal ganglion cells(RGCs)canbe determined in the histology of acute hyperglycemia in the role of expressed Brn3b gene related to nitric oxide(NO),caspase-3,nuclear factor kappa-B(NF-κB),and tumor necrosis factor-α(TNF-α)as an early predictor of primary open angle glaucoma(POAG)eyes and their associations.METHODS:Experimental in vivo study was carried out using adult male,white Sprague-Dawley rats aged≥2 mo,weighing 150-200 g.The animals were divided into two groups,one group receiving intraperitoneal injection of streptozotociz 50 mg/kg in 0.01 mol/L citricbuffer and p H 4.5 and a comparison made with the control group.Retinal tissue was divided into two parts(both experimental and control groups respectively):a)right retina for immunohistochemistry(IHC;caspase-3 and TNF-α);b)left retina was divided into two parts for the purpose of real-time polymerase chain reaction(PCR)test(RNA extraction for Brn3b gene expression analysis)and ELISA test(NO and NF-κB).RESULTS:The experimental group showed a decrease in Brn3b gene expression compared to the control group(1.3-fold lower in 2nd month;1.1-fold lower in 4th month and 2.5-fold lower in 6th month).However,there was a decrease of NO,caspase-3,and an increase of NF-κB and TNF-αquantity.CONCLUSION:The expression of m RNA Brn3b gene is inversely proportional to apoptosis in RGCs.The quantity of NO,caspase-3,NF-κB and TNF-αis influential in expression of Brn3b in RGCs caused by hyperglycemia in diabetic rats. | Irwan Tjandra Purnomo Soeharso Widya Artini Nurjati Chairani Siregar Andi Arus Victor | 2020 | International Journal of Ophthalmology(English edition)2020，13，12： | 2 |
| 3 | Adaptive load shedding of the power system based on neural network 显示文摘 | Purnomo M H Patria C A Purwanto E | 2002 | Computers Communications Control Power Engineering2002，2002，3： | 1 |
| 4 | Oxidative stress and transforming growth factor-β1-induced cardiac fibrosis显示文摘 | Purnomo Y Piccart Y Coenen T | 2013 | Cardiovasc Hematol Disord Drug Targets2013，13，2： | 1 |
| 5 | Effect of land-use changes on nitrous oxide (N20) emission from tropical peatlands 显示文摘 | Hadi A Inubushi K Purnomo E | 2000 | Chemosphere-Global Change Science2000，2，： | 1 |
| 6 | Maximizing Production Rate and Workload Balancing in a Two-sided Assembly Line Using Harmony Search显示文摘 | Purnomo H D Wee H M | 2014 | Computers Industrial Engineering2014，76，： | 1 |
| 7 | vLOD:highfidelity walkthrough of large virtual environments显示文摘 | Chhugani J Purnomo B Krishnan S | 2005 | IEEE Transactions on Visualization and Computer Graphics2005，11，1： | 1 |
| 8 | Oxidative stress and transforming growth factor- β1 -induced cardiac fibrosis显示文摘 | PURNOMO Y PICCART Y COENEN T | 2013 | Cardiovasc Hematol Disord Drug Targets2013，13，2： | 1 |
| 9 | Fucoxanthin Content of Five Species Brown Seaweed from Talango District, Madura Island显示文摘 | K. Zailanie H. Purnomo | 2011 | Journal of Agricultural Science and Technology(A)2011，1，8： | 1 |
| 10 | Sugar components of coconut sugar in Indonesia显示文摘 | Purnomo H | 1992 | Asean Food J1992，7，4： | 1 |
| 11 | Oxidative stress andtransforming growth factor-β1-induced cardiac fibrosis 显示文摘 | Purnomo Y Piccart Y Coenen T | 2013 | Cardiovasc Hematol Disord Drug Targets2013，13，2： | 1 |
| 12 | A column generation-based approach to solve the preference scheduling problem for nurses with downgrading显示文摘 | Bard J F Purnomo H W | 2005 | Socioecon Plann Sci2005，39，3： | 1 |
| 13 | Governing the teak furniture business:a global value chain system dynamic modelling approach显示文摘 | Purnomo H Guizol P Muhtaman D R | 2009 | Environmental Modelling&Software2009，，12： | 1 |
| 14 | Glycosamin- oglycan overproduction in the aorta increases aortic calcification in murine chronic kidney disease显示文摘 | Purnomo E Emoto N Nugrahaningsih DA | 2013 | J Am Heart Assoc2013，2，00： | 1 |
| 15 | Multi-echelon inventory model for repairable item e- mergency with lateral transshipment in retail supply chain 显示文摘 | Purnomo A | 2011 | Australian Journal of Basic and Applied Sciences2011，34，1： | 1 |
| 16 | Measurement of non-enzymatic browning of dehydrated and intermediate moisture meat显示文摘 | BUCKLE K A PURNOMO H | 1986 | J Sci Food Agric1986，37，2： | 1 |
| 17 | Synthesis of pure Na- X and Na-A zeolite from bagasse fly ash 显示文摘 | Purnomo C W Salim C Hinode H | 2012 | Microporousand MesoporousMaterials2012，162，1： | 1 |
| 18 | Effect of ceria loading on the carbon formation during low temperature methane steam refor-ming over a Ni/CeO2/ZrO2 catalyst 显示文摘 | Purnomo A Gallardo S Abella L | 2008 | Reaction Kinetics & Ca- talysis Letters2008，95，： | 1 |
| 19 | Effect of land-use changes on nitrous oxide (N2O ) emission from tropical peatlands显示文摘 | ABDUL H INUBUSHI K PURNOMO E | 2000 | Chemosphere Global Change Science2000，2，： | 1 |
| 20 | Basic studies and applications on bioremediation of DDT:A review 显示文摘 | PURNOMO A S MORI T KAMEI I | 2011 | Interna-tional Biodeterioration & Biodegradation2011，65，7： | 1 |
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