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| 1 | Phytochemical analysis and anticancer capacity of Shemamruthaa,a herbal formulation against DMBA-induced mammary carcinoma in rats显示文摘Objective:To investigate the bioactive-constituents of Shemamruthaa(SM),a herbal combination and its therapeutic effects on the mitochondrial functions with reference to lipid peroxidation(LPO),antioxidant status,citric acid cycle enzymes and electron transport chain enzymes in mammary tissues of 7,12-dimethylbenz(a)-anthracene(DMBA)induced mammary carcinoma in rat model.Methods:Adult Female Sprague-Dawley rats were used for the study and were divided into four groups.CroupⅠserved as control and CroupⅡrats were induced mammary carcinoma by administration of DMBA(25 mg/kg b.w.)orally.The normal and cancer-induced rats(GroupⅢ)were treated with SM(400 mg/kg b.w./day)orally by gastric incubation for 14days.CroupⅣrats served as SM-treated control animals.Results:Cancer-induced rats showed a considerably increased level of LPO with concomitant decreased levels of antioxidants,citric acid cycle enzymes,electron transport chain enzymes and cytochrome contents in the mammary tissue.Treatment with SM brought back the aforementioned biochemical parameters to near normal.Conclusions:From the results,it can be inferred that Shemamruthaa possesses significant anticancer effect through its role in attenuation of LPO,prevention of membrane damage and restoring membrane integrity. | Ayyakkannu Purushothaman Elumalai Nandhakumar Panchanatham Sachdanandam | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，12： | 6 |
| 2 | Prevalence and Mechanism of Nonsteroidal Anti-Inflammatory Drug–Induced Clinical Relapse in Patients With Inflammatory Bowel Disease显示文摘 | Ken Takeuchi Simon Smale Purushothaman Premchand Laurence Maiden Roy Sherwood Bjarni Thjodleifsson Einar Bjornsson Ingvar Bjarnason | 2006 | Clinical Gastroenterology and Hepatology2006，，2： | 4 |
| 3 | First Complete Genome Sequence of a Probiotic Enterococcus faecium Strain T-110 and Its Comparative Genome Analysis with Pathogenic and Non-pathogenic Enterococcus faecium Genomes显示文摘Enterococci bacteria are important in environmental,food and clinical microbiology.Enterococcus faecium is a nosocomial pathogen that causes bacteremia,endocarditis and other infections.It is among the most prevalent organisms encountered in hospital-associated infections accounting for approximately 12%of nosocomial infections in the USA(Linden and Miller,1999).However,certain strains of E.faecium are not only non-pathogenic but also have | Purushothaman Natarajan Madasamy Parani | 2015 | Journal of Genetics and Genomics2015，42，1： | 3 |
| 4 | Isolation and in silico evaluation of antidiabetic molecules of Cynodon dactylon (L.)显示文摘 | Hasthi V. Annapurna Babu Apoorva Natesan Ravichandran Kallur Purushothaman Arun Pemaiah Brindha Sethuraman Swaminathan Mahadevan Vijayalakshmi Arumugam Nagarajan | 2013 | Journal of Molecular Graphics and Modelling2013，，： | 2 |
| 5 | Quantum Neural Networks (QNN's): Inherently Fuzzy Feedforward neural Networks 显示文摘 | Gopathy Purushothaman Nicolaos B Karayiannis | 1997 | Neural Networks1997，，： | 1 |
| 6 | Altered glu- cose disposition and insulin sensitivity in peri-pubertal first-degree relatives of women with polycystic ovary syndrome 显示文摘 | Raissouni N Kolesnikov A Purushothaman R | 2012 | In J Pediatr Endocrino12012，2012，： | 1 |
| 7 | Inflamma- tion and neovascularization in diabetic atherosclerosis 显示文摘 | Purushothaman KR Meerarani P Moreno PR | 2007 | Indian J Exp Biol2007，45，1： | 1 |
| 8 | Quantum neural networks (QNN'S): Inherently fuzzy feed forward neural networks显示文摘 | Purushothaman G Karayiannis N B | 1997 | IEEE Transactions on Neural Networks1997，8，3： | 1 |
| 9 | Temporal relation of cardiac hypertrophy, oxidative stress, and fatty acid metabolism in spontaneously hypertensive rat 显示文摘 | Purushothaman S Nair Renuka R Harikrishnan VS | 2011 | Molecular and Cellular Biochemistry2011，351，12： | 1 |
| 10 | Intimomedial interface damage and adventitial inflammation is increased beneath disrupted atherosclerosis in the aorta: implications for plaque vulnerability 显示文摘 | Moreno P R Purushothaman K R Fuster V | 2002 | Circulation2002，105，21： | 1 |
| 11 | Heparanase en- hances the insulin receptor signaling pathway to activate extracel- lular signal-regulated kinase in multiple myeloma 显示文摘 | Purushothaman A Babitz SK Sanderson RD | 2012 | J Biol Chem2012，287，41： | 1 |
| 12 | Effect of probiotics on bacterial population and health status of shrimp in culture pond ecosystem 显示文摘 | DALMIN G KATHIRESAN K PURUSHOTHAMAN A | 2001 | Indian J Exp Biol2001，39，9： | 1 |
| 13 | An Experi- mental Study of Flash Evaporation from Liquid Pools 显示文摘 | Gopalakrishna S Purushothaman V Lior N | 1987 | Desalination1987，65，11： | 1 |
| 14 | Haptoglobin genotype is a major determinant of the amount of iron in the human atherosclerotic plaque显示文摘 | Moreno PR Purushothaman KR Meerarani P | | 0，，13： | 1 |
| 15 | Minimizing makespan on a batch-processing machine with non-identical job sizes using genetic algorithms显示文摘 | Purushothaman D Paraveen K M Krishnaswami S | 2006 | International Journal of Production Economics2006，103，2： | 1 |
| 16 | Malabarieones A-D, Novel Diarylnonanoids from Myristica malabarica Lam (Myristieaeeae) 显示文摘 | Purushothaman K K Sarada A Connolly J D | 1977 | J Chem Soe Perkin Trans I1977，，5： | 1 |
| 17 | Combined effects of Solanum trilobatum and Solanum melongena against 13-galactosamine induced hepatic damage in rats with reference to marker enzymes and antioxidants status 显示文摘 | Purushothaman A Ahmad T Meenatchi P | 2012 | Biochem: An Indian J2012，6，2： | 1 |
| 18 | Development of conducting adhesive materials for microelectronic applications显示文摘 | Sung K. Kang S. Purushothaman | 1999 | Journal of Electronic Materials1999，，11： | 1 |
| 19 | Peste des petits ruminants of sheep in India显示文摘 | Shaila M S Purushothaman V Bhavasar D | 1989 | Vet Rec1989，125，24： | 1 |
| 20 | 4, 6, 7-trimethoxy-5-methylchromen-2-one, a new coumarin from Leonotis nepetaefolia 显示文摘 | Purushothaman K K Vasanth S Madras A | 1976 | J C S Perkin I1976，，： | 1 |
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