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| 1 | Platelet-to-lymphocyte ratio in the setting of liver transplantation for hepatocellular cancer: A systematic review and meta-analysis显示文摘AIM To perform a systematic review and meta-analysis on platelet-to-lymphocyte ratio(PLR) as a risk factor for post-transplant hepatocellular cancer(HCC) recurrence. METHODS A systematic literature search was performed using PubM ed. Participants of any age and sex, who underwent liver transplantation for HCC were considered following these criteria:(1) studies comparing pre-transplant low vs high PLR values;(2) studies reporting post-transplant recurrence rates; and(3) if more than one study was reported by the same institute, only the most recent was included. The primary outcome measure was set for HCC recurrence after transplantation. RESULTS A total of 5 articles, published between 2014 and 2017, fulfilled the selection criteria. As for the quality of the reported studies, all the investigated articles presented an overall high quality. A total of 899 cases were investigated: 718 cases(80.0%) were males. Three studies coming from European countries and one from Japan presented HCV as the main cause of cirrhosis. On the opposite, one Chinese study presented a greater incidence of HBV-related cirrhotic cases. In all the studies apart one, the PLR cut-off value of 150 was reported. At meta-analysis, high PLR value was associated with a significant increase in recurrence after transplantation(OR = 3.33; 95%CI: 1.78-6.25; P < 0.001). A moderate heterogeneity was observed among the identified studies according to the Higgins I^2 statistic value.CONCLUSION Pre-transplant high PLR values are connected with an increased risk of post-operative recurrence of hepatocellular cancer. More studies are needed for better clarify the biological mechanisms of this results. | Quirino Lai Fabio Melandro Zoe Larghi Laureiro Francesco Giovanardi Stefano Ginanni Corradini Flaminia Ferri Redan Hassan Massimo Rossi Gianluca Mennini | 2018 | World Journal of Gastroenterology2018，24，15： | 19 |
| 2 | Hypothermic oxygenated perfusion for a steatotic liver graft显示文摘To the Editor:Donor steatosis represents a well-known risk factor for primary non-function,early allograft dysfunction,and biliary complications after liver transplantation(LT)[1,2].Recently,machine perfusion(MP)technology has been implemented in the clinical practice,with the primary intent to assess the graft quality and to optimize the organ selection process[3].A limited number of articles has been published specifically investigated the role of MP in steatotic livers[4–10],with few of them looking at the role of hypothermic MP. | Quirino Lai Franco Ruberto Fabio Melandro Zoe Larghi Laureiro Massimo Rossi Gianluca Mennini | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，1： | 7 |
| 3 | From portal to splanchnic venous thrombosis:What surgeons should bear in mind显示文摘The present study aims to review the evolution of surgical management of portal(PVT) and splanch-nic venous thrombosis(SVT) in the context of liver transplantation over the last 5 decades. PVT is more commonly managed by endovenous thrombectomy, while SVT requires more complex technical expedients. Several surgical techniques have been proposed, such as extensive eversion thrombectomy, anastomosis to collateral veins, reno-portal anastomosis, cavo-portal hemi-transposition, portal arterialization and combined liver-intestinal transplantation. In order to achieve satisfactory outcomes, careful planning of the surgical strategy is mandatory. The excellent results that are ob-tained nowadays confirm that, even extended, splanch-nic thrombosis is no longer an absolute contraindication for liver transplantation. Patients with advanced portal thrombosis may preferentially be referred to specialized centres, in which complex vascular approaches and even multivisceral transplantation are performed. | Quirino Lai Gabriele Spoletini Rafael S Pinheiro Fabio Melandro Nicola Guglielmo Jan Lerut | 2014 | World Journal of Hepatology2014，6，8： | 6 |
| 4 | Right ventricular septal pacing: Safety and efficacy in a long term follow up显示文摘AIM: To evaluate the safety and efficacy of the permanent high interventricular septal pacing in a long term follow up, as alternative to right ventricular apical pacing. METHODS: We retrospectively evaluated:(1) 244 patients(74 ± 8 years; 169 men, 75 women) implanted with a single(132 pts) or dual chamber(112 pts) pacemaker(PM) with ventricular screw-in lead placed at the right ventricular high septal parahisian site(SEPTAL pacing);(2) 22 patients with permanent pacemaker and low percentage of pacing(< 20%)(NO pacing);(3) 33 patients with high percentage(> 80%) right ventricular apical pacing(RVA). All patients had a narrow spontaneous QRS(101 ± 14 ms). We evaluated New York Heart Association(NYHA) class, quality of life(Qo L), 6 min walking test(6MWT) and left ventricular function(end-diastolic volume, LV-EDV; end-systolic volume, LVESV; ejection fraction, LV-EF) with 2D-echocardiography. RESULTS: Pacing parameters were stable duringfollow up(21 mo/patient). In SEPTAL pacing group we observed an improvement in NYHA class, Qo L score and 6MWT. While LV-EDV didn't significantly increase(104 ± 40 m L vs 100 ± 37 m L; P = 0.35), LV-ESV slightly increased(55 ± 31 m L vs 49 ± 27 m L; P = 0.05) and LV-EF slightly decreased(49% ± 11% vs 53% ± 11%; P = 0.001) but never falling < 45%. In the RVA pacing control group we observed a worsening of NYHA class and an important reduction of LV-EF(from 56% ± 6% to 43% ± 9%, P < 0.0001).CONCLUSION: Right ventricular permanent high septal pacing is safe and effective in a long term follow up evaluation; it could be a good alternative to the conventional RVA pacing in order to avoid its deleterious effects. | Eraldo Occhetta Gianluca Quirino Lara Baduena Rosaria Nappo Chiara Cavallino Emanuela Facchini Paolo Pistelli Andrea Magnani Miriam Bortnik Gabriella Francalacci Gabriele Dell’Era Laura Plebani Paolo Marino | 2015 | World Journal of Cardiology2015，7，8： | 5 |
| 5 | Uncommon indications for associating liver partition and portal vein ligation for staged hepatectomy:a systematic review显示文摘Associating liver partition and portal vein ligation for staged hepatectomy(ALPPS)represents an innovative surgical technique used for the treatment of large hepatic lesions at high risk for post-resection liver failure due to a small future liver remnant.The most significant amount of literature concerns the use of ALPPS for the treatment of hepatocellular carcinoma(HCC),cholangiocarcinoma(CCC),and colorectal liver metastases(CRLM).On the opposite,few is known about the role of ALPPS for the treatment of uncommon liver pathologies.The objective of the present study was to evaluate the current literature on this topic.A systematic review was performed according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses(PRISMA)guidelines.Eligible articles published up to February 2020 were included using the MEDLINE,Scopus,and Cochrane databases.Among the 486 articles screened,45 papers met the inclusion criteria,with 136 described cases of ALPPS for rare indications.These 136 cases were reported in 18 different countries.Only in two countries,namely Germany and Brazil,more than ten cases were observed.As for the ALPPS indications,we reported 41(30.1%)cases of neuroendocrine tumor(NET)metastases,followed by 27(19.9%)cases of gallbladder cancer(GBC),nine(6.6%)pediatric cases,six(4.4%)gastrointestinal stromal tumors,six(4.4%)adult cases of benign primary liver disease,four(2.9%)adult cases of malignant primary liver disease,and 43(31.6%)adult cases of malignant secondary liver disease.According to the International ALPPS Registry data,less than 10%of the ALPPS procedures have been performed for the treatment of uncommon liver pathologies.NET and GBC are the unique pathologies with acceptable numerosity.ALPPS for NET appears to be a safe procedure,with satisfactory long-term results.On the opposite,the results observed for the treatment of GBC are poor.However,these data should be considered with caution.The rationale for treating benign pathologies with ALPPS appears to be weak.No definitive response should be given for all the other pathologies.Multicenter studies are needed with the intent to clarify the potentially beneficial effect of ALPPS for their treatment. | Quirino Lai Gianluca Mennini Zoe Larghi Laureiro Massimo Rossi | 2021 | Hepatobiliary Surgery and Nutrition2021，10，2： | 4 |
| 6 | QUANTITATIVE EVALUATIONS OF MECHANISMS OF RADIOFREQUENCY INTERACTIONS WITH BIOLOGICAL MOLECULES AND PROCESSES显示文摘 | Asher R. Sheppard Mays L. Swicord Quirino Balzano | 2008 | Health Physics2008，，4： | 2 |
| 7 | Complex hepatic outflow reconstruction in domino liver transplantation显示文摘Domino liver transplantation has been accepted as a safe procedure to further expand the organ donor pool. The most important technical challenge of the procedure resides in restoring a proper hepatic venous allograft outflow in the familial amyloidotic polyneuropathy-liver recipient. To overcome this issue, combined techniques were used to perform an innovative outflow reconstruction. A domino liver transplantation was successfully performed with reconstruction of complex venous outflow. The inferior vena cava sparing hepatectomy technique in the familial amyloidotic polyneuropathy-donor was used to cut the hepatic vein to the liver parenchyma. To overcome this issue the venous outflow tract was reconstructed using a longitudinally opened iliac vein graft from a post-mortem donor to create a new outflow tract using a diamond patch between the right and middle/left hepatic veins. | Rafael S Pinheiro Quirino Lai Carola Dahrenmoller Jan Lerut | 2014 | Hepatobiliary & Pancreatic Diseases International2014，13，1： | 2 |
| 8 | Sweeping of neutral analytes in electrokinetic chromatography with high-salt-containing matrixes显示文摘 | QUIRINO J P TERABE S BOCEK P | 2000 | Anal Chem2000，72，8： | 1 |
| 9 | 显示文摘 | QUIRINO J P TERABE S | 1998 | Science1998，282，： | 1 |
| 10 | Molec- ular aspects of leaf senescence显示文摘 | QUIRINO B F NOH Y S HIMELBLAU E AMASINO R M | 2000 | Trends in Plant Science2000，5，7： | 1 |
| 11 | BCLC staging system and liver transplantation:From a stage to a therapeutic hierarchy显示文摘The Barcelona Clinic Liver Cancer(BCLC)system was proposed in 1999 with the intent to improve a therapeutic algorithm for the management of patients with hepatocellular carcinoma(HCC)[1].Both the European and the American Guidelines on the Treatment of HCC have endorsed the BCLC as the standard staging algorithm with prognostic and therapeutic implications[2,3].The BCLC staging system stratifies HCC patients into five stages(0,A,B,C and D).According to the algorithm,liver transplantation(LT)is indicated only in patients in the stages BCLC 0 and A,special situations provided. | Quirino Lai Alessandro Vitale | 2021 | Hepatobiliary & Pancreatic Diseases International2021，20，1： | 1 |
| 12 | Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass显示文摘 | Chello M Mastroroberto P Quirino A | 2002 | Ann Thorac Surg2002，73，1： | 1 |
| 13 | Inhibition of neutrophil apoptosis after coronary bypass operation with cardiopulmonary bypass显示文摘 | Chello M Mastroroberto P Quirino A | 2002 | Ann Thorac Surg2002，73，1： | 1 |
| 14 | Biodiesel compatibility with carbon steel and HDPE parts显示文摘 | Marcia Marie Maru Marcia Maria Lucchese Cristiano Legnani Welber Gianini Quirino Andrea Balbo Isabele Bulh?es Aranha Lílian Terezinha Costa Cecília Vilani Lídia ágata de Sena Jailton Carreteiro Damasceno Talita dos Santos Cruz Leandro Reis Lidízio Rui Fer | 2009 | Fuel Processing Technology2009，，9： | 1 |
| 15 | Phenotypic and geno- typic evaluation of slime production by conventional and molecu-lar microbiological techniques 显示文摘 | Liberto MC Matera G Quirino A | 2009 | Microbiol Res2009，164，5： | 1 |
| 16 | Escamoles Ant Eggs Liometopumapiculatumm Source of Metal Ions for Human Health显示文摘 | Virginia Melo Concepcion Calvo Tomas Quirino Susana Macin Ileana Muniz | 2013 | Journal of Chemistry and Chemical Engineering2013，7，6： | 1 |
| 17 | Molecular aspects of leaf senescence: Trends显示文摘 | Quirino B F Noh Y S Himelblau E | 2000 | Plant Science2000，5，： | 1 |
| 18 | Large volume sample stacking of positively chargeable analytes in capillary zone electrophoresis without polarity switching:use of low reversed electroosmotic flow induced by a cationic surfactant at acidic pH显示文摘 | Quirino J P | 2000 | Electrophoresis2000，21，： | 1 |
| 19 | On-line concentration of neutral analytes for MEKC Ⅲ: Stacking with reverse migration micelles 显示文摘 | QUIRINO J P TERABE S | 1998 | Anal Chem1998，70，： | 1 |
| 20 | Stacking of neutral analytes for MEKC 显示文摘 | QUIRINO J P TERABE S | 1997 | J Capillary Electrophoresis1997，，4： | 1 |
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