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| 1 | Fondaparinux预防老年急性内科患者发生静脉血栓形成的效果与安全性:随机安慰剂对照研究显示文摘目的:观察 Fondaparinux 对具有中高度静脉血栓发生危险的老年急性内科住院患者的抗凝效果与安全性。设计:双盲随机安慰剂对照研究。背景:8个国家的35个中心。参与者:849例≥60岁内科患者,住院原因分别为充血性心力衰竭、慢性肺病合并急性呼吸系统疾患、急性炎症性或感染性疾病,预期至少住院4天以上。干预:2.5 mg Fondaparinux 或安慰剂,每天1次皮下注射,持续6~14天。观察指标:主要指标为静脉血栓形成(治疗后15天内采用双侧静脉造影检查)及有症状的静脉血栓;次要指标为死亡与出血。患者随访时间为1个月。结果:Fondaparinux 治疗组425例患者和安慰剂组414例患者接受了安全性分析(10例未治疗)。644例患者(75.9%)可接受主要指标分析。静脉血栓检出率在 Fondaparinux 治疗组为5.6%(18/321),安慰剂组为10.5%(34/323),相对危险减少46.7%(95% CI 7.7%~69.3%)。安慰剂组5例患者发生有症状的静脉血栓,Fondaparinux治疗组无患者发生有症状的静脉血栓(P=0.029)。两组均有1例(0.2%)患者发生严重出血。随访结束时,安慰剂组、Fondaparinux 治疗组分别死亡25(6.0%)、14(3.3%)例患者。结论:Fondaparinux 可有效预防急性内科老年患者无症状性及有症状的静脉血栓。严重出血几率两组相似。 | Alexander T Cohen Bruce L Davidson Alexander S Gallus Michael R Lassen Martin H Prins Witold Tomkowski Alexander G G Turpie Jan F M Egberts Anthonie W A Lensing 石汉平(译) 王深明(校) | 2006 | 英国医学杂志中文版2006，9，5： | 3 |
| 2 | Evaluating evidence-based medicine skills during a performance-based examination显示文摘 | Davidson ra Duerson M Romrell L Pauly R Watson rt | 2004 | Acad Med2004，79，3： | 1 |
| 3 | A preliminary cost curve assessment of carbon dioxide capture and storage potential in China显示文摘 | Dahowski R T Li X Davidson C L | 2009 | Energy ProcedJa2009，1，1： | 1 |
| 4 | Kahakamides A and B, new neosidomycin metabolites from a marine-derived actinomycete 显示文摘 | Schumacher R W Harrigan B L Davidson B S | 2001 | Tetrahedron Lett2001，42，31： | 1 |
| 5 | Schwertmannite inwet,acid and oxic microenvironments beneath polar and polyther-mal glaciers显示文摘 | Raiswell R Benning L G Davidson L | 2009 | Geology2009，37，5： | 1 |
| 6 | 显示文摘 | Halvorson R H Erickson R L Davidson C L | 2003 | Dental Materials2003，19，： | 1 |
| 7 | Specific isolation of RNA from the grape powdery mildew pathogen Erysiphe necator, an epiphytic, obligate parasite 显示文摘 | Cadle - Davidson L Wakefield L Seem R C | 2009 | Journal of phytopathology2009，158，1： | 1 |
| 8 | Rivaroxaban versus enoxaparin for thromboprophylaxis after total knee arthroplasty (RECORD4): a randomised trial显示文摘 | Turpie A G Lassen M R Davidson B L | 2009 | Lancet2009，373，9676： | 1 |
| 9 | The life histories of Botryosphaeria melanops and Massaria platani显示文摘 | Shear C L Davidson R W | 1936 | Mycologia1936，28，： | 1 |
| 10 | Preclinical and pharmacology of Rosuvastatin, a new 3 - hydroxy - 3 - meth- ylgutaryl coenzyme A reductase inhibitor 显示文摘 | MCTAGGART F BUCKETF L DAVIDSON R | 2001 | Am J Cardiol2001，87，5： | 1 |
| 11 | Adenoviralmediated transfer of the TNF-related apoptosis-inducing ligand Apo-2 ligand gene induces tumor cell apoptosis显示文摘 | Griffith T S Anderson R D Davidson B L | 2000 | J Immunol2000，165，5： | 1 |
| 12 | Dysfunction in the neural circuitry of emotion regulation-a possible prelude to violence显示文摘 | Davidson R J Putnam K M Larson C L | | 0，，5479： | 1 |
| 13 | The Influence of Edaphic Factors onthe Species Composition of Early Stages of the Subsere显示文摘 | DAVIDSON R L | 1962 | The Journal of Ecology1962，50，2： | 1 |
| 14 | Families' experience with seeking treatment for recent-onset psychosis 显示文摘 | Gerson R Davidson L Booty A | 2009 | Psychiatr Serv2009，60，6： | 1 |
| 15 | A Prelimi- nary Cost Curve Assessment of Carbon Dioxide Capture and Storage Potential in China 显示文摘 | R T DAHOWSKI X LI C L DAVIDSON | 2009 | Energy Procedia2009，1，： | 1 |
| 16 | The B-K method:application to methyene显示文摘 | Davidson E R McMurchie L E Day S J | 1981 | J Chem Phys1981，74，： | 1 |
| 17 | Deep root function in soil water dynamics in Cerrado savannas of central Brazil显示文摘 | Oliveira R S Bezerra L Davidson E A | 2005 | Functional Ecology2005，19，4： | 1 |
| 18 | Fatigue and fracture toughness of a Nb - Ti - Cr - A1 - X single-phase alloy at ambient temperature显示文摘 | Davidson D L Chan K S Loloee R | 2000 | Metall Mater Trans A2000，31，： | 1 |
| 19 | Relations bewween PET- derved measures of thalamic glucose metabolism and EEG alpha power 显示文摘 | Larson C L Davidson R J Abercmmbie H C | 1998 | Psychophysioloty1998，35，2： | 1 |
| 20 | Gonadotropin-releasing hormone (GnRH) antagonists promote proapoptotie signaling in peripheral reproductive tumor cells by activating a Galphai-coupling state of the type I GnRH receptor显示文摘 | Maudsley S Davidson L Pawson A J Chan R Lopez de Maturana R Millar R P | 2004 | CancerRes2004，64，： | 1 |
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