|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S Cardozo Pelaez F | | 0，，： | 2 |
| 3 | Adult bone marrow stromal cells differentiate into neural cells in vivo显示文摘 | Sanchez - Ramos J Song S Cardozo - Pelaez F | 2000 | Exp Neurol2000，164，： | 1 |
| 4 | Adult bone marrow stromal cell differentiate into neural cells in vitro显示文摘 | Sanchez Ramos J Song S CARDOZO pelac F | 2000 | ExpNeuro 12000，164，： | 1 |
| 5 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez - Ramos J Song S Cardozo - Plaez F | 2000 | Exp Neurol2000，164，2： | 1 |
| 6 | Effect of Some Compatibilizing Agents on Clay Dispersion of Polypropylene-clay Nanocomposites 显示文摘 | Lopez-Quintanilla M L Sanchez-Valdes S Ramos de Valles L F | 2006 | J Appl Polym Sei2006，100，： | 1 |
| 7 | Gaussian Process Modeling of Large Scale Terrain显示文摘 | Vasudevan S Ramos F Nettleton E | | 0，，10： | 1 |
| 8 | Thermal properties of hybrid lignocellulosic fabric-reinforced polyester matrix composites显示文摘 | Alsina O L S L H de Carvalho Ramos Filho F G | 2005 | Polymer Testing2005，24，： | 1 |
| 9 | Role of dehydration catalyst acid properties on one-step DME synthesis over physical mixtures显示文摘 | Ramos F S De Farias A M D Borges L E P | 2005 | Catal Today2005，101，1： | 1 |
| 10 | Postantibiotic effect of ciprofloxacin compared with that of five other quinolones 显示文摘 | Minguez F Ramos C Barrientos S | 1991 | Chemotherapy1991，37，6： | 1 |
| 11 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez -Ramos J Song S Cardozo-Pelaez F | 2000 | Exp Neural2000，164，2： | 1 |
| 12 | Adult bone marrow stromal cells differentiate into neural cells in vitro显示文摘 | Sanchez- Ramos J Song S Cardozo- Pelaez F | 2000 | Exp Neurol2000，164，2： | 1 |
| 13 | Adsorptive voltammetric study of thorium-alizarin complexon complex at a carbon paste electrode显示文摘 | Marcos F Teixeira S Luiz Ramos A | 2003 | Microchimica Acta2003，143，4： | 1 |
| 14 | Production of an Extracellular Polysaccharide with Emulsifier Properties by Penicillium citrinum 显示文摘 | CAMARGO-DE-MORAIS M M RAMOS S A F PIMENTEL M C B | 2003 | World J Microbiol &Biotechnol2003，19，2： | 1 |
| 15 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | FUSARO A F BOCCA S N RAMOS R L | 2007 | Planta2007，225，5： | 1 |
| 16 | Effect of some compatibilizing agents on clay dispersion of polypropyleneclay nanocomposites 显示文摘 | Lopez-Quintanilla M L Sanchez-Valdes S Ramos de Valle L F | 2006 | Journal of Applied Polymer Science2006，100，6： | 1 |
| 17 | Effect of Some Compatibilizing Agents on Clay Dispersion of Polypropylene-Clay Nanocomposites显示文摘 | Lopez-Quintanilla M L Sanchez V S Ramos de Valle L F | | Journal of Applied Polymer Science0，100，： | 1 |
| 18 | AtGRP2, a cold-induced nucleo-cytoplasmic RNA-binding protein, has a role in flower and seed development显示文摘 | Fusaro A F Bocca S N Ramos R L B | 2007 | Planta2007，225，6： | 1 |
| 19 | Phase Ⅱ study of radiochemotherapy with UFT and low-dose oral leucovorin in patients with unresectable rectal cancer 显示文摘 | De La Torre A Ramos S Valca'rcel F | 1999 | Int J Radiat Oncol Biol Phys1999，45，3： | 1 |
| 20 | Genomie organization and ex- pression profile of the small GTPases of the RhoBTB family in human and mouse 显示文摘 | Ramos S Khademi F Somesh BP | 2002 | Gene2002，298，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员