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| 1 | Stage and size using magnetic resonance imaging and endosonography in neoadjuvantly-treated rectal cancer显示文摘AIM: To assess the stage and size of rectal tumours using 1.5 Tesla (1.5T) magnetic resonance imaging (MRI) and three-dimensional (3D) endosonography (ERUS). METHODS: In this study, patients were recruited in a phaseⅠ/Ⅱ trial of neoadjuvant chemotherapy for biopsy-proven rectal cancer planned for surgical resection with or without preoperative radiotherapy. The feasibility and accuracy of 1.5T MRI and 3D ERUS were compared with the histopathology of the fixed surgical specimen (pathology) to determine the stage and size of the rectal cancer before and after neoadjuvant chemotherapy. A Philips Intera 1.5T with a cardiac 5-channel synergy surface coil was used for the MRI, and a B-K Medical Falcon 2101 EXL 3D-Probe was used at 13 MHz for the ERUS. Our hypothesis was that the staging accuracy would be the same when using MRI, ERUS and a combination of MRI and ERUS. For the combination, MRI was chosen for the assessment of the lymph nodes, and ERUS was chosen for the assessment of perirectal tissue penetration. The stage was dichotomised into stageⅠ and stage Ⅱ or greater. The size was measured as the supero-inferior length and the maximal transaxial area of the tumour. RESULTS: The staging feasibility was 37 of 37 for the MRI and 29 of 36 for the ERUS, with stenosis as a limiting factor. Complete sets of investigations were available in 18 patients for size and 23 patients for stage. The stage accuracy by MRI, ERUS and the combination of MRI and ERUS was 0.65, 0.70 and 0.74, respectively, before chemotherapy and 0.65, 0.78 and 0.83, respectively, after chemotherapy. The improvement of the post-chemotherapy staging using the combination of MRI and ERUS compared with the staging using MRI alone was significant (P = 0.046). The post-chemotherapy understaging frequency by MRI, ERUS and the combination of MRI and ERUS was 0.18, 0.14 and 0.045, respectively, and these differences were non-significant. The measurements of the supero-inferior length by ERUS compared with MRI were within 1.96 standard deviations of the difference between the methods (18 mm) for tumours smaller than 50 mm. The agreement with pathology was within 1.96 standard deviations of the difference between imaging and pathology for all tumours with MRI (15 mm) and for tumours that did not exceed 50 mm with ERUS (22 mm). Tumours exceeding 50 mm in length could not be reliably measured by ERUS due to the limit in the length of each recording. CONCLUSION: MRI is preferable to use when assessing the size of large or stenotic rectal tumours. However, staging accuracy is improved by combining MRI with ERUS. | Torbjrn Swartling Peter Klebo Kristoffer Derwinger Bengt Gustavsson Gran Kurlberg | 2013 | World Journal of Gastroenterology2013，19，21： | 9 |
| 2 | Irritable bowel syndrome subtypes differ in body awareness, psychological symptoms and biochemical stress markers显示文摘AIM: To elucidate the differences in somatic, psycho-logical and biochemical pattern between the subtypes of irritable bowel syndrome (IBS). METHODS: Eighty IBS patients, 30 diarrhoea pre-dominant (D-IBS), 16 constipation predominant (C-IBS) and 34 alternating IBS (A-IBS) underwent physi-otherapeutic examinations for dysfunctions in body movements and awareness and were compared to an apparently healthy control group (AHC). All groups an-swered questionnaires for gastrointestinal and psycho-logical symptoms. Biochemical variables were analysed in blood. RESULTS: The D-IBS group showed less body aware-ness, less psychological symptoms, a more normal sense of coherence and psychosocial rating as well as higher C-peptide values. C-IBS had a higher degree of body dysfunction and psychological symptoms, as well as the lowest sense of coherence compared to controls and D-IBS. They also demonstrated the most elevated prolactin levels. A-IBS had the lowest degree of body disturbance, deteriorated quality of life and affected bi-ochemical pattern. All subtypes had higher pain scores compared to controls. In addition they all had signifi -cantly increased triglycerides and elevated morning cortisol levels, however, without statistical signifi cance compared with the controls.CONCLUSION: IBS subtypes showed different pro-files in body awareness, somatic and psychological symptoms and in biochemical variables. D-IBS differed compared to the other groups by lowered body aware-ness, less psychological symptoms and a higher sense of coherence and elevated C-peptide values. C-IBS and A-IBS subtypes suffered more from depression and anxiety, associated with a lower quality of life. These differences may be important and will be taken into account in our treatment of these patients. | Elsa M Eriksson Kristina I Andrén Henry T Eriksson Gran K Kurlberg | 2008 | World Journal of Gastroenterology2008，14，31： | 7 |
| 3 | Measuring efficiency of Indian ports: an application of data envelopment analysis显示文摘 | CHUDASAMA K M K/RAN P | 2008 | Icfai Univ J Infrastructure2008，6，2： | 1 |
| 4 | Is Local Government Efficiency Measurement in Australia Adequate? An Analysis of the Evidence显示文摘 | Wondbury K Dollery B E Prasada Ran K S | 2003 | Public Productivity and Management Review2003，27，2： | 1 |
| 5 | Design and Technology Preparation for the ITER HTSCL显示文摘 | Zhou T Lu K Ran Q | 2014 | Applied Superconductivity IEEE Trans- actionson2014，24，3： | 1 |
| 6 | Mechanical properties for bulk metallic glass with crystallites precipitation and second ductile phase addition显示文摘 | Qiu K Q Hao D Z Ran Y L | 2007 | Journal of Materials Science2007，42，9： | 1 |
| 7 | A new 0-1 integer programming method of feeder reconfiguration for loss minimization in distribution systems显示文摘 | Sarma N D R Prakasa Ran K S | 1995 | Electric Power System Research1995，，33： | 1 |
| 8 | Real-time detection of intermittent misfiring in a voltage-fed PWM inverter induction-motor drive 显示文摘 | Smith K S Ran L Penman J | 1997 | IEEE Transactions on Industrial Electronics1997，44，4： | 1 |
| 9 | Experimental studies of thin-ply laminated coposites显示文摘 | Sangwook S Ran Y K Kazumasa K | 2006 | Composites science and tech- nology2006，67，6： | 1 |
| 10 | Delayed preconditioning by scvoflurane elicits changes in the mitochondrial proteome in ischemia-repeffused rat hearts 显示文摘 | Xiao YY Chang YT Ran K ct al | 2011 | Anesthesia & Analgesia2011，113，2： | 1 |
| 11 | Degradability of forage proteins by in situ and in vitro enzymatic methods 显示文摘 | COBLENTZ W K ABDELGADIR I E O COCH- RAN R C | 1999 | Journal of Dairy Science1999，82，： | 1 |
| 12 | Study of predictive controller tuning methods显示文摘 | Ran K Y Unbehauen H | 1997 | Automatica1997，33，12： | 1 |
| 13 | Chronic obstructive pulmonary disease:current burden and future projections显示文摘 | Lopez AD Shibuya K Ran C | 2006 | Eur Respir2006，27，2： | 1 |
| 14 | Scanning and transmission electron microscopic observation of the parasitic form of Trichophyton violaceum in the infected hair from tinea capitis显示文摘 | Zhuang K Ran X Lei S | 2014 | Scanning2014，36，4： | 1 |
| 15 | An evolution in the management of sinonasal inverting papilloma显示文摘 | RAN J K SMT1H T L LOEHRL T | 2001 | Laryngoscope2001，111，8： | 1 |
| 16 | Lymphangiogenesis and lymphatic- metastasis in breast cancer 显示文摘 | Ran S Volk L Hall K | 2010 | Pathophysiology2010，17，4： | 1 |
| 17 | Optical and electronic properties of doubly ortho - linked cis - 4,4' - bis ( diarylami- no) stilbene/fluorene hybrids 显示文摘 | Liu Y L Ran X Q Feng J K | 2010 | Aust J Chem2010，63，1： | 1 |
| 18 | Conducted electromagnetic emission in induction motor drive system part Ⅰ: Time domain analysis and identification of dominant modes显示文摘 | Li Ran Bradley K J Christopoulos C | 1998 | IEEE Transactions on Power Electronics1998，13，4： | 1 |
| 19 | Expected energy production costs by the method of moments显示文摘 | RAN N S TOY P SCHENK K F | 1980 | IEEE Trans on Power Apparatus and Systems1980，99，5： | 1 |
| 20 | Delayed preconditioning by sevoflurane elicits changes in the mitochondrial proteome in ischemia-reperfused rat hearts显示文摘 | Xiao Y Y Chang Y T Ran K | 2011 | Anesth Analg2011，113，2： | 1 |
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