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| 1 | Metabolism Study on Tobacco-specific N-Nitrosamines in Rabbit by Solid-phase Extraction and Liquid Chromatography-electrospray Ionization-mass Spectrometry Method显示文摘Metabolism of four tobacco-specific N-nitrosamines (TSNAs), N′-nitrosonornicotine (NNN), N′-nitrosoanatabine (NAT), N′-nitrosoanabasine (NAB) and 4-(methyl nitrosamino)-1- (3-pyridyl)-1-butanone (NNK) was studied by solid-phase extraction (SPE) and liquid chromato- graphy-electrospray ionization-mass spectrometry (LC-ESI-MS). SPE and LC-ESI-MS method was evaluated to be rapid, simple, sensitive and selective for analysis of TSNAs in rabbit serum. The doses of TSNAs administrated were 4.666 μgkg and 11.665 μgkg according to different levels in cigarettes. Metabolic curves of four TSNAs and 4-(methyl nitrosamino)-1-(3-pyridyl)- 1-butanone (NNAL), the metabolite of NNK, were obtained. | Jian Xun ZHANG Chen Chen LI Zheng CHEN Zhi Hua RAO Da Wei WEN Ke An LI Hu Wei LIU | 2005 | Chinese Chemical Letters2005，16，12： | 5 |
| 2 | Identifying disease feature genes based on cellular localized gene functional modules and regulation networks显示文摘Identifying disease-relevant genes and functional modules, based on gene expression pro- files and gene functional knowledge, is of high im- portance for studying disease mechanisms and sub- typing disease phenotypes. Using gene categories of biological process and cellular component in Gene Ontology, we propose an approach to selecting func- tional modules enriched with differentially expressed genes, and identifying the feature functional modules of high disease discriminating abilities. Using the differentially expressed genes in each feature module as the feature genes, we reveal the relevance of the modules to the studied diseases. Using three data- sets for prostate cancer, gastric cancer, and leukemia, we have demonstrated that the proposed modular approach is of high power in identifying functionally integrated feature gene subsets that are highly rele- vant to the disease mechanisms. Our analysis has also shown that the critical disease-relevant genes might be better recognized from the gene regulation network, which is constructed using the characterized functional modules, giving important clues to the concerted mechanisms of the modules responding to complex disease states. In addition, the proposed approach to selecting the disease-relevant genes byjointly considering the gene functional knowledge suggests a new way for precisely classifying disease samples with clear biological interpretations, which is critical for the clinical diagnosis and the elucidation of the pathogenic basis of complex diseases. | ZHANG Min ZHU Jing GUO Zheng LI Xia YANG Da WANG Lei RAO Shaoqi | 2006 | Chinese Science Bulletin2006，51，15： | 3 |
| 3 | Intedeukin-17 and interferon- gamma are produced concomitantly by human coronary artery-infil- trating T cells and act synergistically on vascular smooth muscle cells 显示文摘 | Eid RE Rao DA Zhou J | 2009 | Circulation2009，119，10： | 1 |
| 4 | Simple and robust differentiation of Ganoderma species by high performance thin-layer chromatography coupled with single quadrupole mass spectrometry QDa显示文摘In this study,a high performance thin-layer chromatography/single quadrupole mass spectrometry QDa(HPTLC-QDa)method for robust authentication of Ganoderma lucidum,a popular and valuable herbal medicine,has been developed.This method is simple and practical,which allows direct generation of characteristic mass spectra from the HPTLC plates automatically with the application of in situ solvent desorption interface.The HPTLC silica gel plates were developed with toluene-ethyl formate-formic acid(5:5:0.2,V/V)and all bands were transferred to QDa system directly in situ using 80%methanol with 0.1%formic acid as desorption solvent.The acquired HPTLC-QDa spectra showed that luminous yellow band b3,containing ganoderic acid B/G/H and ganodeneric acid B,the major active components of Ganoderma,could be found only in G.lucidum and G.lucidum(Antler-shaped),but not in G.sinense and G.applanatum.Moreover,bands b13 and b14 with m/z 475/477 and m/z 475/491/495,respectively,could be detected in G.lucidum(Antler-shaped),but not in G.lucidum,thus allowing simple and robust authentication of G.lucidum with confused species.This method is proved to be simple,practical and reproducible,which can be extended to analyze other herbal medicines. | YAO Shuai ZHANG Jian-Qing HOU Jin-Jun HU Xiao-Su WANG Ling DA Juan RAO Wei WANG Dan-Dan HUANG Yong WU Wan-Ying GUO De-An | 2021 | Chinese Journal of Natural Medicines2021，19，4： | 1 |
| 5 | In- fibre Bragg grating temperature sensor system for medical application显示文摘 | Rao YJ Webb DJ Jackson DA | 1997 | J Lightwave Technol1997，15，11： | 1 |
| 6 | Endothelial injury, alarmins, and al- lograft rejection显示文摘 | Rao DA Pober JS | 2008 | Crit Rev Immunol2008，28，22： | 1 |
| 7 | Interleukin-17 and interferon- gamma are produced concomitantly by human coronary artery-in- filtrating T cells and act synergistically on vascular smooth muscle cells显示文摘 | Eid RE Rao DA Zhou J | 2009 | Circulation2009，119，10： | 1 |
| 8 | Response of early-and late-maturing commercial Leghorn pullets to low levels of dietary phosphorus显示文摘 | Rao SK Roland DA Hoerr FJ | 1992 | Poultry Sci1992，71，： | 1 |
| 9 | The CWSI variations of cotton crop in a semi-arid region of Northeast Brazil显示文摘 | B Barbosa da Silva T V Ramana Rao | 2005 | Journal of Arid Environments2005，62，4： | 1 |
| 10 | Myeloperoxidase- antineutrophil cytoplasmic antibodies (MPO-AN- CA) and proteinase 3-ANCA without immunofluo- rescent ANCA found by routine clinical testing显示文摘 | Rao DA Wei K Merola JF | 2015 | J Rheumatol2015，42，5： | 1 |
| 11 | Androgen receptor and Kennedy disease/spinal bulbar muscular atrophy显示文摘 | Monks DA Rao P Mo K | 2008 | Horm Behav2008，53，5： | 1 |
| 12 | Interleukin-17 and interferon-gammaare produced concomitantly by human coronary artery-infiltrating Tcells and act synergistically on vascular smooth muscle cells 显示文摘 | Eid RE Rao DA Zhou J | 2009 | Circulation2009，119，10： | 1 |
| 13 | Amelioration of human allograft arterial injury by atorvastatin or simvastain correlates with reduction of interferon-gamma production by infiltrating T cells显示文摘 | Yi T Rao DA Tang PC | 2008 | Trarsplantation2008，86，5： | 1 |
| 14 | Interleukin-17 and interferon-gammaare produced concomitantly by human coronary artery-infltratingT cells and act synergistically on vascular smooth muscle cells显示文摘 | Eid RE Rao DA Zhou J | 2009 | Circulation2009，119，10： | 1 |
| 15 | Multi-drug loaded polymeric micelles for simultaneous delivery of poorly soluble anticancer drugs 显示文摘 | Shin HC Alani AW Rao DA | 2009 | J Control Release2009，140，3： | 1 |
| 16 | Amelioration of human allograft arterial injury by atorvastatin or simvastatin correlates with reduction of inter- feron-gamma production by infiltrating T cells 显示文摘 | Yi T Rao DA Tang PC | 2008 | Transplantation2008，86，5： | 1 |
| 17 | IL-1alpha and IL-1beta are endogenous mediators linking cell injury to the adaptive alloimmune response显示文摘 | Rao DA Tracey KJ Pober JS | 2007 | J Immunol2007，179，10： | 1 |
| 18 | In-situ XRD study on the peritectic reaction of YBCO thin film on MgO substrate显示文摘 | Qunli Rao Xiaolan Fan Da Shu C.C. Wu | 2007 | Journal of Alloys and Compounds2007，，1： | 1 |
| 19 | Prediction of septicemia following endourological manipulation for stones in the upper urinary tract 显示文摘 | Rao PN Dube DA Weightman NC | 1991 | J Urol1991，146，4： | 1 |
| 20 | Nasal lavage leukotrienes in infants with bronchiolitis显示文摘 | da Dalt L Cal legaro S Car rao S | 2007 | Pediatr Allergy Immunol2007，18，2： | 1 |
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