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| 1 | Intestinal alkaline phosphatase in the colonic mucosa of children with inflammatory bowel disease显示文摘AIM:To investigate intestinal alkaline phosphatase(iAP) in the intestinal mucosa of children with inflammatory bowel disease(IBD).METHODS:Colonic biopsy samples were taken from 15 newly diagnosed IBD patients and from 10 healthy controls.In IBD patients,specimens were obtainedboth from inflamed and non-inflamed areas.The iAP mRNA and protein expression was determined by reverse transcription-polymerase chain reaction and Western blotting analysis,respectively.Tissue localization of iAP and Toll-like receptor(TLR) 4 was investigated by immunofluorescent staining.RESULTS:The iAP protein level in the inflamed mucosa of children with Crohn's disease(CD) and ulcerative colitis(UC) was significantly decreased when compared with controls(both P < 0.05).Similarly,we found a significantly decreased level of iAP protein in the inflamed mucosa in CD compared with non-inflamed mucosa in CD(P < 0.05).In addition,the iAP protein level in inflamed colonic mucosa in patients with UC was decreased compared with non-inflamed mucosa in patients with CD(P < 0.05).iAP protein levels in the non-inflamed mucosa of patients with CD were similar to controls.iAP mRNA expression in inflamed colonic mucosa of children with CD and UC was not significantly different from that in non-inflamed colonic mucosa with CD.Expression of iAP mRNA in patients with noninflamed mucosa and in controls were similar.Co-localization of iAP with TLR4 showed intense staining with a dotted-like pattern.iAP was present in the inflamed and non-inflamed mucosa of patients with CD,UC,and in control biopsy specimens,irrespective of whether it was present in the terminal ileum or in the colon.However,the fluorescent signal of TLR4 was more pronounced in the colon compared with the terminal ileum in all groups studied.CONCLUSION:Lower than normal iAP protein levels in inflamed mucosa of IBD patients may indicate a role for iAP in inflammatory lesions in IBD.Based on our results,administration of exogenous iAP enzyme to patients with the active form of IBD may be a therapeutic option. | Kriszta Molnár dám Vannay Beáta Szebeni Nóra Fanni Bánki Erna Sziksz ron Cseh Hajnalka Gyrffy Péter László Lakatos Mária Papp András Arató Gábor Veres | 2012 | World Journal of Gastroenterology2012，18，25： | 5 |
| 2 | Carbon membraneds from precursors containing low-carbon residual polymers显示文摘 | Linkov Vhdimir M Sanderson Ron D Jacobs Ed P | 1994 | Polymer International1994，35，3： | 1 |
| 3 | Proteomic analysis of dendritic cell-derived exosomes:a secreted subcellular compartment distinct from apoptotic vesicles显示文摘 | Théry C Boussac M Véron P | 2001 | J Immunol2001，166，12： | 1 |
| 4 | Flow in the engine com-partment:analysis and optimization显示文摘 | D’Hondt M Gilliéron P Devinant P | 2011 | International Journal ofAerodynamics2011，134，： | 1 |
| 5 | Stroke unit care benifits patients with intracerebral hemorrhage: systematic review and meta-analysis 显示文摘 | LANGHORNE P FEARON P RONNING O M | 2013 | Stroke2013，44，11： | 1 |
| 6 | A core collection of common bean from the Iberian peninsula 显示文摘 | Rodino A P Santalla M Ron A M D | 2003 | Euphytica2003，131，： | 1 |
| 7 | Genetic study of the CD36 gene In a French diabetic population显示文摘 | F Leprêtre KJ Linton C Lacquemant V Vatin C Samson C Dina M Chikri S Ali P Scherer K Séron F Vasseur T Aitman P Froguel | 2004 | Diabetes and Metabolism2004，，5： | 1 |
| 8 | Tolerance of liver biopsy in a tertiary care center: comparison of the percutaneous and the transvenous route in 143 prospectively followed patients显示文摘 | Bogdan Procopet Christophe Bureau Sophie Métivier Janick Selves Marie Angèle Robic Camille Christol Mircea Grigorescu Jean-Pierre Vinel Jean-Marie Péron | 2012 | European Journal of Gastroenterology & Hepatology2012，，10： | 1 |
| 9 | Detection performance prediction on IR images assisted by evolutionary learning显示文摘 | Ron P Harley R M | 1999 | SPIE1999，，3699： | 1 |
| 10 | Lower Risk of Cancer in Patients on Metformin in Comparison With Those on Sulfonylurea Derivatives: Results from a large population-based follow-up study显示文摘 | Ruiter Rikje Visser Loes E van Herk-Sukel Myrthe P P Coebergh Jan-Willem W Haak Harm R Geelhoed-Duijvestijn Petronella H Straus Sabine M J M Herings Ron M C Stricker Bruno H CH | 2012 | Diabetes Care2012，，1： | 1 |
| 11 | Incidence and predictors for post-stroke epilepsy:A long-term prospective controlled study (The Akershus stroke study)显示文摘 | Lossius M I Ronning O M Mowinckel P | 2005 | Epilepsia2005，46，8： | 1 |
| 12 | Liver stiffness accurately predicts portal hypertension related complications in patients with chronic liver disease: A prospective study显示文摘 | Marie Angèle Robic Bogdan Procopet Sophie Métivier Jean Marie Péron Janick Selves Jean Pierre Vinel Christophe Bureau | 2011 | Journal of Hepatology2011，，5： | 1 |
| 13 | Genetic testing and genetic counselling in hypertrophic cardiomyopathy:the French experience显示文摘 | Charron P Héron D Gargiulo M | 2002 | J Med Genet2002，39，： | 1 |
| 14 | The Bootstrap:a tutorial显示文摘 | Ron W Hein P Lutgrade M C | 2000 | Chemometrics and Intelligent Laboratory System2000，54，： | 1 |
| 15 | A core collection of common bean from the Iberian peninsula显示文摘 | Rodi(n)o A P Santalla M Ron A M D | 2003 | Euphytica2003，131，： | 1 |
| 16 | Adult stromal cells derived from human adipose tissue provoke pancreatic cancer cell death both in vitro and in vivo显示文摘 | Cousin B Ravet E Poglio S De Toni F Bertuzzi M Lulka H Touil I André M Grolleau JL Péron JM Chavoin JP Bourin P Pénicaud L Casteilla L Buscail L Cordelier P | | 0，，： | 1 |
| 17 | Thyroid cancer and multiple primary tumors in the SEER cancer registries显示文摘 | RONCKERS C M MCCARRON P RON E | 2005 | Int J Cancer2005，117，2： | 1 |
| 18 | A core collection of common bean from the Iberian peninsula显示文摘 | Rodino A P Santalla M Ron A M D | 2003 | Euphytica2003，131，： | 1 |
| 19 | The bootstrap:a tutorial显示文摘 | Ron W Hein P Lutgrade M C | 2000 | Chemometrics and Intelligent Laboratory System2000，54，： | 1 |
| 20 | C/ATF,a member of the activating transcription factor family of DNA-binding proteins, dimerizes with CAAT/enhancer-binding proteins and directs their binding to cAMP response elements显示文摘 | VALLEJO M RON D MILLER C P | 1993 | Proc Nail Acad Sci USA1993，90，10： | 1 |
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