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| 1 | 通过手术导致的重量损失由胃绕过在疾病的肥胖的病人改进非含酒精的脂肪肝疾病显示文摘 AIM:To evaluate the effects of surgical weight loss(Roux-en-Y gastric bypass with a modified Fobi-Capella technique) on non alcoholic fatty liver disease in obese patients.METHODS:A group of 26 morbidly obese patients aged 45 ± 2 years and with a body mass index > 40 kg/m 2 who underwent open surgical weight loss operations had paired liver biopsies,the first at surgery and the second after 16 ± 3 mo of weight loss.Biopsies were evaluated and compared in a blinded fashion.The presence of metabolic syndrome,anthropometric and biochemical variables were also assessed at baseline and at the time of the second biopsy.RESULTS:Percentage of excess weight loss was 72.1% ± 6.6%.There was a reduction in prevalence of metabolic syndrome from 57.7%(15 patients) to 7.7%(2 patients)(P < 0.001).Any significance difference was observed in aspartate aminotransferase or alanine aminotransferase between pre and postsurgery.There were improvements in steatosis(P < 0.001),lobular(P < 0.001) and portal(P < 0.05) inflammation and fibrosis(P < 0.001) at the second biopsy.There were 25(96.1%) patients with non alcoholic steatohepatitis(NASH) in their index biopsy and only four(15.3%) of the repeat biopsies fulfilled the criteria for NASH.The persistence of fibrosis(F > 1) was present in five patients at second biopsy.Steatosis and fibrosis at surgery were predictors of significant fibrosis postsurgery.CONCLUSION:Restrictive mildly malabsorptive surgery provides significant weight loss,resolution of metabolic syndrome and associated abnormal liver histological features in most obese patients. | Víctor Vargas Helena Allende Albert Lecube Maria Teresa Salcedo Juan A Baena-Fustegueras José M Fort Joaquín Rivero Roser Ferrer Roberto Catalán Eva Pardina Santiago Ramón y Cajal Jaime Guardia Julia Peinado-Onsurbe | 2012 | World Journal of Hepatology2012，4，12： | 6 |
| 2 | Intestinal pseudo-obstruction caused by herpes zoster:Case report and pathophysiology显示文摘Herpes zoster(HZ) infection occurs in approximately 10% to 30% of individuals. Visceral neuropathies secondary to HZ can cause cystitis and urinary retention. But colonic pseudo-obstruction can also occur. Peripheral neuropathy may reveal segmental motor paresis of either upper or lower limbs, the abdominal muscles or the diaphragm. We report the case of a 62-year-old male patient who presented with abdominal distention and cutaneous vesicular eruption on the left side of the abdominal wall. Plain X-rays and computed tomography scan showed distended small bowel. A diagnosis of intestinal pseudo-obstruction was made secondary to segmental paresis of the small intestine and visceral neuropathy. Conservative management was successful and the patient was discharged uneventfully. Intestinal pseudo-obstruction ought to be consideredwhen dealing with non-obstructive(adynamic) conditions of the digestive tract associated with HZ infection; since early recognition may help to avoid unnecessary surgery. | Roberto Anaya-Prado José V Pérez-Navarro Ana Corona-Nakamura Michelle M Anaya-Fernández Roberto Anaya-Fernández Marian Eliza Izaguirre-Pérez | 2018 | World Journal of Clinical Cases2018，6，6： | 4 |
| 3 | Celiac disease serology in patients with different pretest probabilities: Is biopsy avoidable?显示文摘AIM: To establish the diagnostic performance of sev-eral serological tests, individually and in combination, for diagnosing celiac disease (CD) in patients with different pretest probabilities, and to explore potential se- rological algorithms to reduce the necessity for biopsy. METHODS: We prospectively performed duodenal biopsy and serology in 679 adults who had either high risk (n = 161) or low risk (n = 518) for CD. Blood samples were tested using six assays (enzyme-linked immunosorbent assay) that detected antibodies to tissue transglutaminase (tTG) and deamidated gliadin peptide (DGP). RESULTS: CD prevalence was 39.1% in the high-risk population and 3.3% in the low-risk group. In high-risk patients, all individual assays had a high diagnostic efficacy [area under receiving operator characteristic curves (AU ROC): 0.968 to 0.999]. In contrast, assays had a lower diagnostic efficacy (AU ROC: 0.835 to 0.972) in the low-risk group. Using assay combinations, it would be possible to reach or rule out diagnosis of CD without biopsy in 92% of cases in both pretest populations. We observed that the new DGP/tTG Screen assay resulted in a surplus compared to more conventional assays in any clinical situation. CONCLUSION: The DGP/tTG Screen assay could be considered as the best initial test for CD. Combinations of two tests, including a DGP/tTG Screen, might be able to diagnose CD accurately in different clinical scenarios making biopsy avoidable in a high proportion of subjects. | Emilia Sugai María L Moreno Hui J Hwang Ana Cabanne Adriana Crivelli Fabio Nach-man Horacio Vázquez Sonia Niveloni Julio Argonz Roberto Mazure Graciela La Motta María E Caniggia Edgardo Smecuol Néstor Chopita Juan C Gómez Eduardo Maurińo Julio C Bai | 2010 | World Journal of Gastroenterology2010，16，25： | 4 |
| 4 | Transarterial chemoembolization using 40 μm drug eluting beads for hepatocellular carcinoma显示文摘AIM To assess the safety and efficacy of transarterial chemoembolization(TACE) of hepatocellular carcinoma(HCC) using a new generation of 40 μm drug eluting beads in patients not eligible for curative treatment.METHODS Drug eluting bead TACE(DEB-TACE) using a new generation of microspheres(embozene tandem,40 μm) preloaded with 100 mg of doxorubicin was performed on 48 early or intermediate HCC patients with compensatedcirrhosis.Response to therapy was assessed with Response Evaluation Criteria in Solid Tumors(RECIST) and modified RECIST(m RECIST) guidelines applied to computed tomography or magnetic resonance imaging.Eleven out of the 48 treated patients treated progressed on to receive liver orthotopic transplantation(OLT).This allowed for histological analysis on the treated explanted nodules.RESULTS DEB-TACE with 40 μm showed a good safety profile without major complications or 30-d mortality.The objective response rate of treated tumors was 72.6% and 26.7% according to m RECIST and RECIST respectively.Histological examination in 11 patients assigned to OLT showed a necrosis degree > 90% in 78.6% of cases.The overall time to progression was 13 mo(11-21).CONCLUSION DEB-TACE with 40 μm particles is an effective treatment for the treatment of HCC in early-intermediate patients(Barcelona Clinic Liver Cancer stage A/B) with a good safety profile and good results in term of objective response rate and necrosis. | Giorgio Greco Tommaso Cascella Antonio Facciorusso Roberto Nani Rodolfo Lanocita Carlo Morosi Marta Vaiani Giuseppina Calareso Francesca G Greco Antonio Ragnanese Marco A Bongini Alfonso V Marchianò Vincenzo Mazzaferro Carlo Spreafico | 2017 | World Journal of Radiology2017，9，5： | 3 |
| 5 | Analysis of chloride diffusion into partially saturated concrete 显示文摘 | Anna V S Roberto V S | 1993 | ACI Material Journal1993，，5： | 1 |
| 6 | Stress analysis of concrete structures subjected to variable thermal loads 显示文摘 | Anna S Roberto S Renato V | 1995 | Journal of Structural Engineering1995，121，3： | 1 |
| 7 | Multiplex PCR for Diagnosis of Enteric Infections Associated with Diarrheagenic Escherichia coli 显示文摘 | Roberto V Maricel V Rossana L | 2004 | J Clin Microbiol2004，42，4： | 1 |
| 8 | Efficacy of some biodegradable films as pre-harvest covering material for guava显示文摘 | Bilck A P Roberto S R Eiras Grossmann M V | 2011 | Scientia Horticulturae2011，130，1： | 1 |
| 9 | The Psychometric Properties of the Orthogonal Cultural Identification Scale in Asian Americans显示文摘 | Mona L J Tamara LW Carmen G Linda TG Roberto J V | 2002 | Journal of Multicultural Counseling and Development2002，，30： | 1 |
| 10 | Maternal serum adiponectin multimersin gestational diabetes显示文摘 | Shali MT Roberto R Edi V | 2009 | Perinat Med2009，37，6： | 1 |
| 11 | Operation setting nomograms for Unidrench Venturi injector显示文摘 | Roberto V Montoya Y E | 2010 | Agronomia Colombiana2010，28，2： | 1 |
| 12 | The mechanism of stochastic resonance显示文摘 | Roberto B Alfonso S Angelo V | 1981 | J Phys A:Math Gen1981，14，： | 1 |
| 13 | Hyperbaric oxygen therapy with short duration intratympanic steroid ther- apy for sudden hearing loss 显示文摘 | Roberto F Giuseppe A Marika V | 2012 | Acta Oto - laryngologi- ca2012，，5： | 1 |
| 14 | Adaptation of the van Genuchten expression to the effects of empera- ture and density for compacted bentonites 显示文摘 | JACINTO A C VILLAR M V ROBERTO G E | 2009 | Applied Clay Science2009，42，34： | 1 |
| 15 | Self-organized multi-camera network for a fast and easy de-ployment of ubiquitous robots in unknown environments显示文摘 | Adrian Canedo-Rodriguez Iglesias Roberto Regueiro Carlos V | | 0，，01： | 1 |
| 16 | Specific Identification and Targeted Characterization of Bifidobacterium Lactis from Different Environmental lsolates by a Combined Multiplex-PCR Approach显示文摘 | Roberto R Ralf Z | 2001 | Applied and Environmental Micmbidogy2001，67，6： | 1 |
| 17 | 查看详情显示文摘 | María L G P Patricia P B Roberto R G José L M V Antonia G F | | 0，，27： | 1 |
| 18 | Inhibitory Action of Aqueous Coffee Ground Extracts on the Corrosion of Carbon Steel in HCl Solution显示文摘 | VANESSA V T ROBERTO S A CAMILA F de S | | 0，，07： | 1 |
| 19 | Atrial fibrillation in hypertension显示文摘 | Paolo V GianPaolo R Roberto G | 2003 | Hypertension2003，41，1： | 1 |
| 20 | Analysis of chloride dif- fusion into partially saturated concrete 显示文摘 | Saetta Anna V Scotta Roberto V | 1993 | ACI Material Journal1993，，5： | 1 |
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